Article
Endocrinology & Metabolism
Guangmin Zuo, Liping Xuan, Zhuojun Xin, Yu Xu, Jieli Lu, Yuhong Chen, Meng Dai, Di Zhang, Weiqing Wang, Mian Li, Yufang Bi, Guang Ning, Min Xu
Summary: This study found that the development of NAFLD and progression of fibrosis are associated with an increased risk of incident CKD. However, the risk of CKD was not significantly different between resolution of NAFLD and persistent NAFLD. Within the persistent NAFLD group, progression of fibrosis to intermediate or high NFS was significantly associated with an increased risk of incident CKD compared to stable fibrosis in low NFS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yifan Sun, Liang Hong, Zhe Huang, Lihong Wang, Yanqin Xiong, Shuhang Zong, Rui Zhang, Jun Liu, Shufei Zang
Summary: The study found that NAFLD, fibrosis, and type 2 diabetes had an additive interaction on chronic kidney disease incidence. The increased risk of NAFLD fibrosis was closely associated with chronic kidney disease in elderly patients with type 2 diabetes. FIB-4 performed better than NFS in predicting chronic kidney disease development.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Anna Di Sessa, Stefano Guarino, Rosa Melone, Rossella Francesca De Simone, Pierluigi Marzuillo, Emanuele Miraglia del Giudice
Summary: The relationship between nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) has sparked scientific interest in recent years, especially in children. Studies suggest that NAFLD may act as a risk factor for CKD from an early age, potentially leading to an increased risk of cardiovascular and metabolic diseases. Due to the progressive nature and heightened cardiometabolic risk associated with NAFLD and CKD, the focus has shifted to exploring the link between these diseases in childhood.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Editorial Material
Medicine, General & Internal
Guadalupe Garcia-Tsao
Summary: NASH has become the main cause of cirrhosis and liver transplantation, unlike hepatitis C which is a liver-specific disorder. It is a complex metabolic disorder that requires finding alternative therapies and defining response to treatment, with diagnosis established through liver biopsy samples.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Gwyneth Soon, Aileen Wee
Summary: Accurate assessment of liver fibrosis is crucial in predicting disease outcomes and evaluating therapeutic response in NAFLD/NASH. While histological assessment remains the gold standard, advances in SHG/TPEF microscopy imaging show promise in providing more detailed measurement. The application of artificial intelligence can further refine quantitative fibrosis scoring methods.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: Dr. Xiao et al. found no association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with incident dementia and cognition. Interestingly, there was a lower risk of incident dementia in the first 5 years after NAFLD diagnosis. The authors suggest that this may simply reflect the absence of weight loss rather than any true protective effect against dementia.
Article
Endocrinology & Metabolism
Chan-Young Jung, Geun Woo Ryu, Hyung Woo Kim, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim
Summary: The study showed a significant association between advanced liver fibrosis measured by transient elastography (TE) and an increased risk of incident chronic kidney disease (CKD) in individuals with non-alcoholic fatty liver disease (NAFLD) who do not have baseline CKD.
Article
Gastroenterology & Hepatology
Jian Wang, Jiacheng Liu, Yilin Liu, Ruifei Xue, Jie Zhan, Suling Jiang, Li Wang, Xiaomin Yan, Yali Xiong, Juan Xia, Shengxia Yin, Xin Tong, Yuxin Chen, Jie Li, Rui Huang, Chao Wu
Summary: This study found that lean patients with chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD) accounted for 25% of the CHB-NAFLD patients. Compared to nonlean patients, lean patients had a lower proportion of metabolic abnormalities and advanced liver fibrosis, but had higher levels of HBsAg, HBV DNA, and HBeAg-positive proportions.
HEPATOLOGY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Chan -Young Jung, Ho Soo Chun, Minjong Lee, Hee Byung Koh, Keun Hyung Park, Young Su Joo, Hyung Woo Kim, Sang Hoon Ahn, Jung Tak Park, Seung Up Kim
Summary: This study indicates that moderate exercise in NAFLD patients can reduce the risk of chronic kidney disease, both prevalent and incident.
DIABETES & METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Ziwen Tao, Yueyue Li, Baoquan Cheng, Tao Zhou, Yanjing Gao
Summary: Nonalcoholic fatty liver disease (NAFLD) has been linked to chronic kidney disease (CKD), but studies have produced conflicting results. This review discusses several studies and explores the potential risk factors and biological mechanisms of CKD in NAFLD, aiming to help clinicians identify CKD earlier and reduce the need for liver and kidney transplants.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Immunology
Ke-qian Chen, Bo-yi Ke, Lu Cheng, Xiao-qing Yu, Zong-bao Wang, Shu-zhi Wang
Summary: With the development of the social economy, unhealthy living habits and eating styles are gradually affecting people's health in recent years. NAFLD, as a chronic liver disease, has become an increasingly serious public health problem due to these factors. Inflammasomes, as a protein complex, play a crucial role in the development of NAFLD and other diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Multidisciplinary Sciences
George Agyapong, Farzaneh Dashti, Bubu A. A. Banini
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and a leading indication for liver transplantation in the United States. This manuscript provides an overview of NAFLD risk factors, natural history, diagnosis, and current management strategies.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Goh-Eun Chung, Kyungdo Han, Kyu-Na Lee, Eun-Ju Cho, Jung-Ho Bae, Sun-Young Yang, Su-Jong Yu, Seung-Ho Choi, Jeong-Yoon Yim, Nam-Ju Heo
Summary: This study investigated the combined effect of chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD) on the risk of cardiovascular disease (CVD) in patients with type 2 diabetes. The results showed that patients with CKD and NAFLD had a higher risk of myocardial infarction (MI), stroke, and mortality compared to other groups. The study emphasizes the importance of monitoring and managing CKD and NAFLD in order to prevent CVD in patients with type 2 diabetes.
Review
Biochemistry & Molecular Biology
Arianna Pani, Francesco Baratta, Daniele Pastori, Mattia Coronati, Francesco Scaglione, Maria del Ben
Summary: This narrative review explores the role of polyphenols in treating and preventing complications of diabetes. Polyphenols have shown potential in combating endothelial damage, oxidative stress, and inflammatory states associated with diabetes complications. However, more clinical trials are needed to determine the effectiveness of these compounds.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Simona Bartimoccia, Vittoria Cammisotto, Cristina Nocella, Maria Del Ben, Alessandra D'Amico, Valentina Castellani, Francesco Baratta, Pasquale Pignatelli, Lorenzo Loffredo, Francesco Violi, Roberto Carnevale
Summary: The study found that extra virgin olive oil can improve postprandial glycemia by reducing low-grade endotoxemia derived from gut permeability. These results demonstrate the importance of using extra virgin olive oil for blood sugar control.
Article
Nutrition & Dietetics
Francesco Baratta, Vittoria Cammisotto, Giulia Tozzi, Mattia Coronati, Simona Bartimoccia, Valentina Castellani, Cristina Nocella, Alessandra D'Amico, Francesco Angelico, Roberto Carnevale, Pasquale Pignatelli, Maria Del Ben
Summary: NAFLD patients with high adherence to the Med-Diet show lower platelet activation and liver collagen deposition, suggesting a protective role of the Med-Diet against NAFLD progression and cardiovascular risk.
Article
Nutrition & Dietetics
Mattia Coronati, Francesco Baratta, Daniele Pastori, Domenico Ferro, Francesco Angelico, Maria Del Ben
Summary: Studies have found that fructose added to foods via high fructose corn syrup and sucrose could contribute to the onset and progression of NAFLD and MetS. Fructose affects liver function through multiple pathways, including inducing de novo lipogenesis, triggering endoplasmic reticulum stress and liver inflammation, reducing fatty acids oxidation, and increasing intestinal permeability. In addition, fructose intake is also associated with weight gain and hypertension.
Article
Biochemistry & Molecular Biology
Vittoria Cammisotto, Francesco Baratta, Paola G. Simeone, Cristina Barale, Enrico Lupia, Gioacchino Galardo, Francesca Santilli, Isabella Russo, Pasquale Pignatelli
Summary: PCSK9 is involved in cholesterol metabolism and plays a role in the development of atherosclerosis and atherothrombotic processes, promoting plaque formation and oxidative stress.
Article
Biochemistry & Molecular Biology
Francesco Baratta, Laura D'Erasmo, Alessia Di Costanzo, Ilaria Umbro, Daniele Pastori, Francesco Angelico, Maria Del Ben
Summary: The association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) may be related to shared metabolic risk factors rather than the genetic background of NAFLD.
Article
Biochemistry & Molecular Biology
Pasquale Pignatelli, Francesco Baratta, Raffaella Buzzetti, Alessandra D'Amico, Valentina Castellani, Simona Bartimoccia, Antonio Siena, Luca D'Onofrio, Ernesto Maddaloni, Annachiara Pingitore, Giovanni Alfonso Chiariello, Francesca Santilli, Daniele Pastori, Nicholas Cocomello, Francesco Violi, Maria Del Ben, Vittoria Cammisotto, Roberto Carnevale
Summary: This study demonstrates that gliflozins have antiplatelet and antithrombic effects in patients with T2D, potentially through the modulation of oxidative stress, platelet activation, and thrombus formation.
Review
Medicine, General & Internal
Francesco Angelico, Francesco Baratta, Mattia Coronati, Domenico Ferro, Maria Del Ben
Summary: Metabolic syndrome (MetS) is a common condition with multiple risk factors, including obesity, high blood pressure, and abnormal glucose and lipid levels. It is associated with increased cardiovascular risk and mortality. Dietary patterns, such as the Mediterranean diet and DASH diet, as well as specific nutrients, can have a positive impact on MetS prevention and management. These include increased intake of fiber-rich foods, fish, dairy products, and a variety of unprocessed cereals, legumes, and fruits, while limiting saturated fats and free sugars.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francesco Baratta, Nicholas Cocomello, Mattia Coronati, Domenico Ferro, Daniele Pastori, Francesco Angelico, Maria Del Ben
Summary: Randomized clinical trials have shown that there is a residual cardiovascular risk in patients treated with statins and other lipid-lowering drugs to target LDL-cholesterol. This risk is mainly associated with lipid components other than LDL, particularly remnant cholesterol (RC) and lipoproteins rich in triglycerides. RCs play a major role in the development of atherosclerosis, easily passing through the arterial wall and stimulating the progression of smooth muscle cells and resident macrophages. Further studies and clinical trials are needed to evaluate the effects of drugs on RC levels and the efficacy of reducing RC on cardiovascular events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Roberto Carnevale, Martina Leopizzi, Marcello Dominici, Giulia d'Amati, Simona Bartimoccia, Cristina Nocella, Vittoria Cammisotto, Alessandra D'Amico, Valentina Castellani, Francesco Baratta, Alessia Bertelli, Alessio Arrivi, Danilo Toni, Manuela De Michele, Pasquale Pignatelli, Rossella Marcucci, Francesco Violi
Summary: Patients with vaccine-induced immune thrombotic thrombocytopenia (VITT) exhibit enhanced thrombogenesis through PAD4-mediated NETs formation via cathepsin G-mediated platelet/neutrophil interaction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Nutrition & Dietetics
Cristina Pederiva, Marta Gazzotti, Marcello Arca, Maurizio Averna, Giuseppe Banderali, Giacomo Biasucci, Marta Brambilla, Paola Sabrina Buonuomo, Paolo Calabro, Francesco Cipollone, Nadia Citroni, Sergio D'Addato, Maria Del Ben, Simonetta Genovesi, Ornella Guardamagna, Gabriella Iannuzzo, Lorenzo Iughetti, Giuseppe Mandraffino, Lorenzo Maroni, Giuliana Mombelli, Sandro Muntoni, Fabio Nascimbeni, Angelina Passaro, Fabio Pellegatta, Matteo Pirro, Livia Pisciotta, Roberta Pujia, Riccardo Sarzani, Roberto Scicali, Patrizia Suppressa, Sabina Zambon, Maria Grazia Zenti, Sebastiano Calandra, Alberico Luigi Catapano, Patrizia Tarugi, Federica Galimberti, Manuela Casula, Maria Elena Capra
Summary: Detection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is crucial for reducing morbidity and mortality. This study investigated the current clinical approach to the management and treatment of pediatric patients with suspected FH in Italian lipid clinics, revealing some differences among centers but overall adherence to the European Atherosclerosis Society (EAS) recommendations for FH children and adolescents.