Mambalgin-2 Inhibits Growth, Migration, and Invasion of Metastatic Melanoma Cells by Targeting the Channels Containing an ASIC1a Subunit Whose Up-Regulation Correlates with Poor Survival Prognosis

Hypoxia and Extracellular Acidification as Drivers of Melanoma Progression and Drug Resistance

(2021) Ewelina Dratkiewicz et al.   Cells

Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

(2021) Kirsten Ackermann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

WNT Signaling in Melanoma

(2020) Anna Gajos-Michniewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melanoma stem cell maintenance and chemo-resistance are mediated by CD133 signal to PI3K-dependent pathways

(2020) Siraj M. El Jamal et al.   ONCOGENE

ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest

(2020) M. L. Bychkov et al.   Acta Naturae

Mambalgin-2 Induces Cell Cycle Arrest and Apoptosis in Glioma Cells via Interaction with ASIC1a

(2020) Maxim Bychkov et al.   Cancers

The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells

(2020) Elena Andreucci et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Acidic microenvironment induction of interleukin-8 expression and matrix metalloproteinase-2/-9 activation via acid-sensing ion channel 1 promotes breast cancer cell progression

(2020) Masako Nakanishi et al.   ONCOLOGY REPORTS

Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells

(2019) Oscar C. Y. Yang et al.   Scientific Reports

Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors

(2018) E N Lyukmanova et al.   BRITISH JOURNAL OF PHARMACOLOGY

Frizzled Receptors as Potential Therapeutic Targets in Human Cancers

(2018) Chui-Mian Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions

(2018) Yifan Wang et al.   Frontiers in Pharmacology

Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

(2018) Demeng Sun et al.   Cell Discovery

Migratory Metrics of Wound Healing: A Quantification Approach for in vitro Scratch Assays

(2018) Sagar S. Varankar et al.   Frontiers in Oncology

The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis

(2017) Zhi-hang Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

(2017) T H Dovmark et al.   ONCOGENE

Towards universal approach for bacterial production of three-finger Ly6/uPAR proteins: Case study of cytotoxin I from cobra N. oxiana

(2017) M.A. Shulepko et al.   PROTEIN EXPRESSION AND PURIFICATION

Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cells

(2017) Yu Wu et al.   TUMOR BIOLOGY

ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca2+/RhoA pathway

(2017) Shuai Zhu et al.   Cell Death & Disease

ASIC1a mediates the drug resistance of human hepatocellular carcinoma via the Ca2+/PI3-kinase/AKT signaling pathway

(2016) Yihao Zhang et al.   LABORATORY INVESTIGATION

Acidic tumor microenvironment in human melanoma

(2016) Ines Böhme et al.   Pigment Cell & Melanoma Research

Over-expression of ASIC1a promotes proliferation via activation of the β-catenin/LEF-TCF axis and is associated with disease outcome in liver cancer

(2016) Cheng Jin et al.   Oncotarget

ERK-mediated NF-κB activation through ASIC1 in response to acidosis

(2016) B Chen et al.   Oncogenesis

Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition

(2015) Gilles Mourier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two aspects of ASIC function: Synaptic plasticity and neuronal injury

(2015) Yan Huang et al.   NEUROPHARMACOLOGY

Regulation of breast tumorigenesis through acid sensors

(2015) S C Gupta et al.   ONCOGENE

Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion

(2015) Cheng Jin et al.   TUMOR BIOLOGY

Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells

(2014) Silvia Peppicelli et al.   CLINICAL & EXPERIMENTAL METASTASIS

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

The potential for targeting the STAT3 pathway as a novel therapy for melanoma

(2013) Gregory B Lesinski   Future Oncology

Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels

(2013) Anne Baron et al.   TOXICON

NF-κB as potential target in the treatment of melanoma

(2012) Gabriele Madonna et al.   Journal of Translational Medicine

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes

(2011) Niren Kapoor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?

(2011) Hayden Matthews et al.   INTERNATIONAL JOURNAL OF CANCER

Glioma-specific Cation Conductance Regulates Migration and Cell Cycle Progression

(2011) Arun K. Rooj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4

(2011) K. Ueno et al.   MOLECULAR CANCER THERAPEUTICS

Acid treatment of melanoma cells selects for invasive phenotypes

(2008) Raymond E. Moellering et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cancer/testis genes expression in human melanoma cell lines

(2008) Irina N. Mikhaylova et al.   MELANOMA RESEARCH