Nonsense-Mediated mRNA Decay, a Finely Regulated Mechanism

Nonsense suppression therapies in human genetic diseases

(2021) Patrícia Martins-Dias et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nonsense-mediated RNA decay and its bipolar function in cancer

(2021) Gonçalo Nogueira et al.   Molecular Cancer

UPF1: From mRNA Surveillance to Protein Quality Control

(2021) Hyun Jung Hwang et al.   Biomedicines

Molecular Determinants and Specificity of mRNA with Alternatively-Spliced UPF1 Isoforms, Influenced by an Insertion in the ‘Regulatory Loop’

(2021) Monikaben Padariya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A role for AKT1 in nonsense-mediated mRNA decay

(2021) Martine Palma et al.   NUCLEIC ACIDS RESEARCH

Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum

(2020) Dasa Longman et al.   GENES & DEVELOPMENT

The role of the NMD factor UPF3B in olfactory sensory neurons

(2020) Kun Tan et al.   eLife

Deciphering the molecular mechanism of stop codon readthrough

(2020) Martine Palma et al.   BIOLOGICAL REVIEWS

The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway

(2020) Zhongxia Yi et al.   TRENDS IN GENETICS

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

(2019) Rik G. H. Lindeboom et al.   NATURE GENETICS

Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

(2019) Jennifer L. Johnson et al.   NEURON

Nonsense-mediated mRNA Decay and Cancer

(2018) Maximilian W Popp et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

(2018) Manjeera Gowravaram et al.   NUCLEIC ACIDS RESEARCH

Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

(2018) A’dem Bokhari et al.   Oncogenesis

Mutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and Mice

(2016) Ranad Shaheen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defective control of pre–messenger RNA splicing in human disease

(2016) Benoit Chabot et al.   JOURNAL OF CELL BIOLOGY

The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma

(2016) Lei Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of nonsense-mediated RNA decay by ER stress

(2016) Zhelin Li et al.   RNA

Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

(2016) Evangelos D. Karousis et al.   Wiley Interdisciplinary Reviews-RNA

Mutation of genes controlling mRNA metabolism and protein synthesis predisposes to neurodevelopmental disorders

(2015) F. Sartor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Caspases shutdown nonsense-mediated mRNA decay during apoptosis

(2015) J Jia et al.   CELL DEATH AND DIFFERENTIATION

Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics

(2015) Maximilian W. Popp et al.   Nature Communications

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Intracellular calcium regulates nonsense-mediated mRNA decay

(2014) Andrew Nickless et al.   NATURE MEDICINE

Biological and clinical significance of epigenetic silencing of MARVELD1 gene in lung cancer

(2014) Ming Shi et al.   Scientific Reports

Posttranscriptional Control of the Stem Cell and Neurogenic Programs by the Nonsense-Mediated RNA Decay Pathway

(2014) Chih H. Lou et al.   Cell Reports

MicroRNA 125 represses nonsense-mediated mRNA decay by regulating SMG1 expression

(2013) Gang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dynamic Integration of Splicing within Gene Regulatory Pathways

(2013) Ulrich Braunschweig et al.   CELL

Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay

(2013) Dilek Colak et al.   CELL

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders

(2013) Lam S. Nguyen et al.   HUMAN MOLECULAR GENETICS

Rules that govern UPF1 binding to mRNA 3′ UTRs

(2013) Tatsuaki Kurosaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadening the phenotype associated with mutations in UPF3B: Two further cases with renal dysplasia and variable developmental delay

(2012) Sally Ann Lynch et al.   European Journal of Medical Genetics

Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity

(2012) Toshiaki Shigeoka et al.   NUCLEIC ACIDS RESEARCH

Rescue of nonsense mutations by amlexanox in human cells

(2012) Sara Gonzalez-Hilarion et al.   Orphanet Journal of Rare Diseases

RNA Homeostasis Governed by Cell Type-Specific and Branched Feedback Loops Acting on NMD

(2011) Lulu Huang et al.   MOLECULAR CELL

Identification of a MicroRNA that Activates Gene Expression by Repressing Nonsense-Mediated RNA Decay

(2011) Ivone G. Bruno et al.   MOLECULAR CELL

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Upf1 Senses 3′UTR Length to Potentiate mRNA Decay

(2010) J. Robert Hogg et al.   CELL

A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders

(2010) A M Addington et al.   MOLECULAR PSYCHIATRY

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

(2009) F Laumonnier et al.   MOLECULAR PSYCHIATRY

Comparison of nonsense-mediated mRNA decay efficiency in various murine tissues

(2008) Almoutassem B Zetoune et al.   BMC GENETICS

SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs

(2008) C. Gong et al.   GENES & DEVELOPMENT

Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities

(2008) Nicola Brunetti-Pierri et al.   NATURE GENETICS

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

(2008) E. Huntzinger et al.   RNA

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

(2008) Guramrit Singh et al.   PLOS BIOLOGY

Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

(2008) Andrea B Eberle et al.   PLOS BIOLOGY