Journal
BIOMEDICINES
Volume 9, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9080995
Keywords
nonsense-mediated mRNA decay; UPF1; aggresome; CTIF; mRNA surveillance; protein quality control
Categories
Funding
- NRF (National Research Foundation) of Korea - Korean government (Ministry of Science, ICT, and Future Planning) [NRF-2015R1A3A2033665, 2018R1A5A1024261]
- Korea University
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Selective recognition and removal of faulty transcripts and misfolded polypeptides are essential for cell viability, with NMD serving as a surveillance pathway. UPF1 plays a key role at the molecular level in selectively removing defective transcripts via NMD, and recent advances have highlighted its communication between mRNA surveillance and protein quality control.
Selective recognition and removal of faulty transcripts and misfolded polypeptides are crucial for cell viability. In eukaryotic cells, nonsense-mediated mRNA decay (NMD) constitutes an mRNA surveillance pathway for sensing and degrading aberrant transcripts harboring premature termination codons (PTCs). NMD functions also as a post-transcriptional gene regulatory mechanism by downregulating naturally occurring mRNAs. As NMD is activated only after a ribosome reaches a PTC, PTC-containing mRNAs inevitably produce truncated and potentially misfolded polypeptides as byproducts. To cope with the emergence of misfolded polypeptides, eukaryotic cells have evolved sophisticated mechanisms such as chaperone-mediated protein refolding, rapid degradation of misfolded polypeptides through the ubiquitin-proteasome system, and sequestration of misfolded polypeptides to the aggresome for autophagy-mediated degradation. In this review, we discuss how UPF1, a key NMD factor, contributes to the selective removal of faulty transcripts via NMD at the molecular level. We then highlight recent advances on UPF1-mediated communication between mRNA surveillance and protein quality control.
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