Review
Engineering, Biomedical
Vishnu Priya Murali, Christina A. Holmes
Summary: This review summarizes various biomaterial-based extracellular vesicle (EV) delivery systems used in preclinical tissue regeneration studies and other therapeutic applications. EV-based therapies have shown success in preclinical models for biomedical applications, but the challenge lies in prolonging EV retention at target sites for improved therapeutic efficacy through biomaterial-based systems.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Dandan Zheng, Huitong Ruan, Wei Chen, Yuhui Zhang, Wenguo Cui, Hao Chen, Hongxing Shen
Summary: Extracellular vesicles (EVs) are nano-scale vesicles derived by cell secretion with unique advantages, which benefit their wide applications in regenerative medicine. However, the in vivo therapeutic effect of EVs still greatly restricted by several obstacles. This review summarizes different strategies to enhance EV functions and introduces the latest developments of functionalized EV-loaded biomaterials in different diseases. Challenges and future directions of EVs are also discussed.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Roisin Lynch, Ed C. Lavelle
Summary: Biocompatible and biodegradable biomaterials are widely used in regenerative medicine. Inflammation, though initially essential for wound healing, can have negative effects if prolonged. Therefore, careful consideration should be given to the choice of biomaterials to minimize inflammation.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yidan Xia, Dongxu Wang, Da Liu, Jiayang Su, Ye Jin, Duo Wang, Beibei Han, Ziping Jiang, Bin Liu
Summary: Chitosan and its derivatives have various applications in the medical field, especially in treating skin and soft tissue diseases. Chitosan has antibacterial, antitumor, and immunomodulatory properties, and can be used as a drug-delivery carrier.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shenghai Shen, Langrun Deng, Yiheng Du, Jingjing Gao, Chuanhao Zhang, Yueduo Wang, Zhewen Shen, Yixuan Li, Xiaowen Chen, Hao Chen
Summary: This study provides an in-depth qualitative and quantitative overview of research on biological wound dressings in recent decades. The results show significant progress and extensive global collaboration in the field, with clear knowledge base. The hotspots of research include chitosan hydrogels, bacterial cellulose, active agents, and electrospinning fibers, while the frontiers of research include novel starting materials, precise release systems, and clinical and regenerative medicine applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Anna L. Kersey, Thuy-Uyen Nguyen, Biswadeep Nayak, Irtisha Singh, Akhilesh K. Gaharwar
Summary: Recent developments in biomedical engineering have focused on designing smart and bio-responsive materials. Recent technological advances in biology, specifically in omics techniques, can provide high-throughput functional readouts of the cellular and molecular interactions. These omics-based approaches have the potential to revolutionize biomedical research and replace traditional trial and error approaches in designing the next-generation of biomaterials.
Review
Polymer Science
Anastasia A. Sherstneva, Tatiana S. Demina, Ana P. F. Monteiro, Tatiana A. Akopova, Christian Grandfils, Ange B. Ilangala
Summary: This critical review surveys the most relevant materials and processing techniques for preparing biodegradable microparticles, with a focus on their potential applications in clinical practices, considering regulatory constraints and the feasibility of industrial production.
Article
Biotechnology & Applied Microbiology
Limei Wang, Kedi Xia, Lu Han, Min Zhang, Jihuan Fan, Liu Song, Anqi Liao, Wenyu Wang, Jianfeng Guo
Summary: The study investigated a new therapeutic strategy using Ginkgolide B (GB) and high molecular weight hyaluronan (HA) hydrogel to treat chronic wounds in diabetic patients, showing significant effects on anti-inflammation, promoting healing, and inducing angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Teruki Nii, Yoshiki Katayama
Summary: This review highlights the recent advancements in regenerative medicine utilizing biomaterial technologies. Enhancing cell activity is crucial for regenerative medicine, especially in drug research and tissue repair. Biomaterials play a vital role in supporting cell culture, drug screening, and tissue repair, making them essential for the development of regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul
Summary: This article reviews emerging therapeutic nanoparticles for treating diabetic wounds and discusses their discrete delivery mechanisms and sites of action. The current challenges of these nanoengineered materials for successful clinical translation are critically assessed, along with their potential for growth in the clinical marketplace.
DRUG DISCOVERY TODAY
(2022)
Review
Chemistry, Multidisciplinary
Parinaz Abdollahiyan, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Tissue engineering in regenerative medicine utilizes cells, substrates, and physiologically active biomolecules to generate advanced therapeutic methods, while nanotechnology can accelerate tissue repair by providing dynamic three-dimensional nano-environments.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Materials Science, Multidisciplinary
Tao Yang, Yingfan Chen, Yajing Xu, Xiangyu Liu, Mingying Yang, Chuanbin Mao
Summary: Viruses as biomaterials exhibit minimal toxicity, good biocompatibility, and well-defined structures. They have been utilized in various applications such as targeted therapy, antimicrobial agents, tissue regeneration, disease detection, bioimaging, vaccines, and immunotherapy. This review discusses the exciting applications and the challenges and future directions of using virus-based biomaterials.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Review
Pharmacology & Pharmacy
Izeia Lukin, Itsasne Erezuma, Lidia Maeso, Jon Zarate, Martin Federico Desimone, Taleb H. Al-Tel, Alireza Dolatshahi-Pirouz, Gorka Orive
Summary: Tissue engineering has become a viable medical alternative in response to the increasing lifespan of society. This review focuses on gelatin, a widely used biomaterial in tissue engineering, and discusses ongoing concerns and the latest developments in this field. Advancements in technology, such as 3D bioprinting and gelatin functionalization, have allowed for better replication of native tissue in gelatin-based systems. This breakthrough has implications for both the manufacturing process, making it more practical and cost-effective, and the future use of gelatin in disease detection and diagnosis rather than treatment.
Article
Pharmacology & Pharmacy
Liu Song, Hao Yang, Di Liang, Di Chu, Leilei Yang, Meng Li, Bo Yang, Ying Shi, Zheng Chen, Zhuo Yu, Jianfeng Guo
Summary: Chlorogenic acid shows potential in promoting diabetic wound healing by reducing inflammation, enhancing re-epithelialization and angiogenesis, and facilitating collagen remodeling.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Cell & Tissue Engineering
Yuanhao Xie, Chenqi Tang, Zizhan Huang, Sicheng Zhou, Yuwei Yang, Zi Yin, Boon Chin Heng, Weishan Chen, Xiao Chen, Weiliang Shen
Summary: In vitro extracellular matrix (ECM) remodeling is critical for maintaining stem cell (SC) function. This review summarizes how cells remodel ECM and the significance of ECM remodeling in ex vivo SC culture, as well as outlines the shortcomings of current research and future directions.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Engineering, Biomedical
Li Wang, Xiaolei Guo, Jiaqing Chen, Zhen Zhen, Bin Cao, Wenqian Wan, Yuandong Dou, Haobo Pan, Feng Xu, Zepu Zhang, Jianmei Wang, Daisong Li, Quanyi Guo, Qing Jiang, Yanan Du, Jiakuo Yu, Boon Chin Heng, Qianqian Han, Zigang Ge
Summary: With the interdisciplinary convergence of biology, medicine, and materials science, there is a growing need to bridge the gap between applied basic research and translational products in the field of biomaterials. This article critically examines the developmental pipeline of biodegradable biomaterials and proposes ideas to integrate different mindsets to guide research and translation, reducing unnecessary research efforts and funding.
BIOACTIVE MATERIALS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mei Zhuang, Wuwen Zhang, Nuo Cheng, Ling Zhou, Dan Liu, Hua Yan, Ge Fang, Boon Chin Heng, Yan Sun, Guoqing Tong
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Engineering, Biomedical
Hong Zhang, Yangwu Chen, Chunmei Fan, Richun Liu, Jiayun Huang, Yanjie Zhang, Chenqi Tang, Bo Zhou, Xiaoyi Chen, Wei Ju, Yanyan Zhao, Jie Han, Peishan Wu, Shichen Zhang, Weiliang Shen, Zi Yin, Xiao Chen, Hongwei Ouyang
Summary: 3D microenvironments can regulate stem cell function by modulating critical cell subpopulations, enhancing stem cell characteristics and functions.
Article
Engineering, Biomedical
Qiaomei Tang, Bing Lu, Jian He, Xiao Chen, Qiuli Fu, Haijie Han, Chenqi Luo, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Min Zhou, Ke Yao
Summary: In this study, a novel approach based on exosomes and a thermosensitive hydrogel was developed for the treatment of corneal diseases. This method effectively reduces scar formation and accelerates the healing process by promoting the repair of damaged corneal epithelium and stromal layer.
Article
Engineering, Biomedical
Ting Zou, Shan Jiang, Baicheng Yi, Qixin Chen, Boon Chin Heng, Chengfei Zhang
Summary: The study demonstrated that SCAPs induced in BDNF-GelMA with small molecule cocktail showed significant upregulation of neural markers, exhibiting morphological characteristics similar to neuronal cells, which may provide a therapeutic platform for neurological disorders.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Jiabei Yang, Xuewei Zhang, Jiaqing Chen, Boon Chin Heng, Yangzi Jiang, Xiaoyu Hu, Zigang Ge
Summary: The study highlights the important role of macrophages in cartilage regeneration, showing that they promote regeneration by modulating proliferation and apoptosis. Exogeneous macrophages have therapeutic potential in promoting cartilage regeneration by regulating stem cells. Only M2c macrophages are able to promote regeneration of both cartilage tissues and subchondral bone.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Xiaotian Du, Qin Zhang, Siyuan Wang, Xiao Chen, Yue Wang
Summary: Our analysis identified MCAM as a potential novel prognostic biomarker for osteosarcoma, associated with increased cell migration ability and higher risk of metastasis, leading to poor prognoses in patients with OS.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biology
Kejia Li, Litong Fan, Jianjing Lin, Boon Chin Heng, Zhantao Deng, Qiujian Zheng, Jue Zhang, Yangzi Jiang, Zigang Ge
Summary: Mesenchymal stem cells (MSCs) can benefit from enhanced chondrogenesis through the combination of nanosecond pulsed electric fields and ghrelin. The sequential order of applying these two stimuli is crucial for promoting cartilage regeneration. This study provides new insights and strategies for future cell-based therapies.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Materials Science, Biomaterials
Xiaohan Dai, Yunyang Bai, Boon Chin Heng, Yiping Li, Zhangui Tang, Changjian Lin, Ousheng Liu, Ying He, Xuehui Zhang, Xuliang Deng
Summary: This study designed biomimetic micro/sub-micro hierarchical surfaces on titanium implants to mitigate inflammatory reactions and osteoclastogenesis, enhance osteogenic differentiation, and promote early osseointegration. The biomimetic hierarchical surfaces inhibited M1 macrophage-mediated inflammatory reactions and decreased osteoclast formation. In vivo, the implants with hierarchical surfaces underwent rapid and early osseointegration. This study offers a novel biomimetic strategy for implant-bone osseointegration in osteoporotic patients.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Shichen Zhang, Wei Ju, Xiaoyi Chen, Yanyan Zhao, Lingchong Feng, Zi Yin, Xiao Chen
Summary: This review summarizes recent research on the structure and function of the extracellular matrix (ECM) components of tendons and highlights the application of multiple detection methodologies concerning the structure of ECMs. The focus is on macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. The review also emphasizes future ECM detection methods and the potential for fabricating biomimetic tendons.
BIOACTIVE MATERIALS
(2022)
Article
Rheumatology
Xiaozhao Wang, Qin Wu, Ru Zhang, Zhang Fan, Wenyue Li, Renwei Mao, Zihao Du, Xudong Yao, Yuanzhu Ma, Yiyang Yan, Wei Sun, Hongwei Wu, Wei Wei, Yejun Hu, Yi Hong, Huan Hu, Yi Wen Koh, Wangping Duan, Xiao Chen, Hongwei Ouyang
Summary: This study investigated the deposition and characteristics of minerals in human osteoarthritis (OA) cartilages at different stages and locations using multiple nano-analytical technologies. It found that OA progresses through both top-down calcification at the joint surface and bottom-up calcification at the osteochondral interface. The study provides a refined understanding of the mechanism underlying OA progression and lays the foundation for potential therapeutic targeting strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)
Review
Orthopedics
Zetao Wang, Youguo Liao, Canlong Wang, Chenqi Tang, Cailian Fang, Junchao Luo, Hengzhi Liu, Xianan Mo, Zicheng Wang, Lingfang Shen, Junjuan Wang, Xiao Chen, Zi Yin, Jianyou Li, Weiliang Shen
Summary: Rotator cuff tendinopathy is a common disorder that causes a significant burden. Although stem cell therapy has shown promising results, there are many unresolved issues, such as determining the optimal source and dosage of stem cells, as well as standardizing patient types.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Cell & Tissue Engineering
Junxin Lin, Yuwei Yang, Wenyan Zhou, Chao Dai, Xiao Chen, Yuanhao Xie, Shan Han, Huanhuan Liu, Yejun Hu, Chenqi Tang, Varitsara Bunpetch, Dandan Zhang, Yishan Chen, Xiaohui Zou, Di Chen, Wanlu Liu, Hongwei Ouyang
Summary: This study investigates the pathological mechanism of tendon heterotopic ossification (HO) and proposes a potential treatment method. The expression level of Mohawk (MKX) is decreased in HO tissue, which is correlated with the upregulation of osteochondrogenic and angiogenic gene expression. Single-cell RNA sequencing analysis reveals the excessive activation of osteochondrogenic genes in Mkx(-/-) tendon cells during tenogenesis. Inhibition of angiogenesis using the small-molecule inhibitor BIBF1120 attenuates bone formation and angiogenesis in both Mkx mutant mice and a rat traumatic model of HO.
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
