Article
Immunology
Jiangong Wang, Bin Liu, Fengjiao Sun, Yong Xu, Haiyun Luan, Meizi Yang, Chaoyun Wang, Tiantian Zhang, Zhenyu Zhou, Haijing Yan
Summary: This study found that inhibition of H3R reduced microglia activity and promoted a shift from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype in microglia, thereby attenuating lipopolysaccharide-induced neuroinflammation in mice. Additionally, inhibition of H3R rescued the impairments of neurogenesis and cognitive function caused by neuroinflammation. Mechanistically, the neuroprotective effects of H3R inhibition were mediated by histamine-dependent activation of H2R and reinforcement of CREB-CBP interaction, which led to increased release of anti-inflammatory cytokines and brain-derived neurotrophic factor, as well as decreased release of pro-inflammatory cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Cell Biology
Chuan Qin, Yongning Li, Kewei Wang
Summary: Stem cell therapy improves memory loss and cognitive deficits in animal models with Alzheimer's disease through interactions with hippocampal cells. The transplantation of stem cells alters the pathological state and establishes a new balance mechanism based on multiple signaling pathways, influencing neurogenesis, apoptosis, inflammation, and immunoregulation. This therapy also promotes synaptic reconstruction through autophagy, microglial activity, and remyelination, providing a perspective and challenge for the treatment of Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Ignazio Antignano, Yingxiao Liu, Nina Offermann, Melania Capasso
Summary: This review discusses the latest research on aging microglia, comparing findings in rodent models and human subjects. Understanding the phenotype of aging microglia is crucial for designing better preventive and therapeutic strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Article
Neurosciences
Aleksandar Dobric, Simone N. De Luca, Huei Jiunn Seow, Hao Wang, Kurt Brassington, Stanley M. H. Chan, Kevin Mou, Jonathan Erlich, Stella Liong, Stavros Selemidis, Sarah J. Spencer, Steven Bozinovski, Ross Vlahos
Summary: The study found that chronic cigarette smoke exposure can cause neurocognitive dysfunction, including impaired working memory, accompanied by neuroinflammation and neuropathological changes in the brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Maheedhar Kodali, Sahithi Attaluri, Leelavathi N. Madhu, Bing Shuai, Raghavendra Upadhya, Jenny Jaimes Gonzalez, Xiaolan Rao, Ashok K. Shetty
Summary: The study found that initiating metformin treatment in late middle age can improve cognitive function in old age, possibly through modulation of microglia, proinflammatory cytokines, and autophagy.
Article
Nutrition & Dietetics
Marta Portero-Tresserra, Neus Galofre-Lopez, Elisabet Pallares, Claudia Gimenez-Montes, Carlos Barcia, Roser Granero, Divka Rojic-Becker, Anna Vale-Martinez, Margarita Marti-Nicolovius, Gemma Guillazo-Blanch
Summary: Age-related changes in the brain significantly impact hippocampal structure and function, leading to cognitive impairments such as deteriorating spatial object recognition (SOR) memory. Both intrinsic factors like neuroinflammation and lifestyle factors like diet can influence aging-related brain function and cognitive performance. This study aimed to evaluate the effects of caloric restriction (CR) on SOR memory, hippocampal neuron loss, neurogenesis, and inflammation in aged male rats. The results showed that CR attenuated the decline in SOR memory, hippocampal neuron loss, and microglial activation associated with aging, while also reducing neurogenesis in the dentate gyrus.
Article
Biochemistry & Molecular Biology
Anthony Fernandez-Castaneda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R. O'Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalcin, Kathryn R. Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B. Keough, Lijun Ni, Pamelyn J. Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, Jeff R. Gehlhausen, Jon Klein, Takehiro Takahashi, Julio Silva, Benjamin Israelow, Carolina Lucas, Tianyang Mao, Mario A. Pena-Hernandez, Alexandra Tabachnikova, Robert J. Homer, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Hannes Vogel, Marco M. Hefti, Daniel P. Perl, Shane Liddelow, Rebecca Folkerth, David Putrino, Avindra Nath, Akiko Iwasaki, Michelle Monje
Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.
Article
Immunology
Louise M. Ince, Jeffrey S. Darling, Kevin Sanchez, Kiersten S. Bell, Jennifer K. Melbourne, Lourdes K. Davis, Kimberly Nixon, Andrew D. Gaudet, Laura. K. Fonken
Summary: Aging is associated with changes in immune system reactivity. Male rats show cognitive decline and increased neuroinflammatory responses, while females do not. Sex differences play a crucial role in the mechanism of aging.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Neurosciences
Yi Wang, Maro G. Machizawa, Turner Lisle, Cedric L. Williams, Ryon Clarke, Matthew Anzivino, Irving Kron, Kevin S. Lee
Summary: This study found that suppressing neuroinflammation during the early post-surgical phase can reduce post-operative cognitive dysfunction in cardiac surgery patients and have positive effects on behavioral and neurogenic outcomes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Mengqi Yuan, Haitao Wu
Summary: Astrocytes play a crucial role in controlling processes in the nervous system after brain injury, producing neuroprotective factors while also potentially hindering CNS repair. Understanding the dual role of astrocytes may improve post-brain injury recovery and lead to the development of novel therapeutic strategies for TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Shane M. O'Neil, Emma E. Hans, Starr Jiang, Lynde M. Wangler, Jonathan P. Godbout
Summary: The study found that aged mice's hippocampal microglia had an amplified and prolonged neuroinflammatory response to peripheral LPS challenge. Furthermore, astrocytes in the aged hippocampus showed immunosenescence, with deficits in IL-10R signaling and cholesterol biosynthesis.
Article
Biochemistry & Molecular Biology
Michitaka Fujiwara, Farhana Ferdousi, Hiroko Isoda
Summary: With the progression of an aging society, cognitive aging has become an urgent concern. This study uses the senescence-accelerated mouse-prone 8 (SAMP8) model to investigate molecular changes in the brain cortex, identifying key functional alterations and candidate genes associated with brain aging, as well as pivotal hub genes involved in these functional domains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Samuel B. R. Harley, Emily F. Willis, Samreen N. Shaikh, Daniel G. Blackmore, Pankaj Sah, Marc J. Ruitenberg, Perry F. Bartlett, Jana Vukovic
Summary: Selective removal of BDNF from microglia increases production of newborn neurons and interferes with self-renewal, reducing overall density. Microglial BDNF is identified as an important factor regulating microglial population dynamics and states, influencing neurogenesis under both homeostatic and pathologic conditions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jie-Li Wang, Min-Qiang Tang, Sheng Chen, Xiang-Feng Zheng, Hui-Xian Mo, Sheng-Jun Li, Zheng Wang, Ke-Ming Zhu, Li-Na Ding, Sheng-Yi Liu, Yun-Hai Li, Xiao-Li Tan
PLANT BIOTECHNOLOGY JOURNAL
(2017)
Review
Cell Biology
Ruijiang Zhuo, Pu Rong, Jieli Wang, Rokshana Parvin, Yuru Deng
Summary: NRDS is a newborn disorder caused by deficiency of lung surfactant, with surfactant replacement therapy showing effectiveness in reducing morbidity and mortality. Plasmalogens, known for their antioxidant properties and ability to stabilize non-lamellar structures, are a potential but overlooked component of lung surfactant. A novel synthetic protein-free lung surfactant preparation with plasmalogen modification is proposed as an alternative strategy for therapeutic intervention.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Xing Huang, Linbo Liu, Jie-Li Wang, Mingcheng Bi, Cong Liu, Wenya Liao, Pengfei Wang, Junfeng Liu, Zhanglin Hou, Zhongbin Xu, Fangfu Ye
Summary: Macroporous hydrogel with self-floating properties has promising applications in gastric drug delivery, water purification, and air-liquid interface cell culture. This study presents a new method for buoyancy-assisted microfluidic fabrication of anisotropic hydrogel products, allowing control over internal porosity and shape, with great potential for various applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Cell Biology
Pu Rong, Jie-Li Wang, Angelina Angelova, Zakaria A. Almsherqi, Yuru Deng
Summary: This article explores the relationship between plasmalogens and Platelet-Activating Factor (PAF), suggesting the potential role of plasmalogenic analogs of PAF as modulators and PAF antagonists. The metabolic interconversion of these lipids is discussed as an important factor in preventing and relieving PAF-mediated inflammation, and the possibility of plasmalogen analogs as a new class of bioactive anti-inflammatory drugs is proposed. Additionally, the competition between PAF and its natural plasmalogenic analogs for binding to the PAF receptor is proposed as a mechanistic model and potential therapeutic perspective.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)