Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1–Nup98 Complex to Compete With mRNA Nuclear Export

Sarbecovirus ORF6 proteins hamper the induction of interferon signaling

(2021) Izumi Kimura et al.   Cell Reports

Innate immune and inflammatory responses to SARS-CoV-2: implications for COVID-19

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SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

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Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

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A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Severe Covid-19

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Dysregulated adaptive immune response contributes to severe COVID-19

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Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

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SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism underlying selective inhibition of mRNA nuclear export by herpesvirus protein ORF10

(2020) Han Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex

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Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

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Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

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Accessory proteins of SARS-CoV and other coronaviruses

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Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1bulletNup98)

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MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

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Improvement of molecular-replacement models withSculptor

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(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

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MolProbity: all-atom structure validation for macromolecular crystallography

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