Human in silico trials for parametric computational fluid dynamics investigation of cerebrospinal fluid drug delivery: impact of injection location, injection protocol, and physiology

Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients

(2020) Lucas R. Sass et al.   Fluids and Barriers of the CNS

In vitro and numerical simulation of blood removal from cerebrospinal fluid: comparison of lumbar drain to Neurapheresis therapy

(2020) Mohammadreza Khani et al.   Fluids and Barriers of the CNS

Convective forces increase rostral delivery of intrathecal radiotracers and antisense oligonucleotides in the cynomolgus monkey nervous system

(2020) Jenna M. Sullivan et al.   Journal of Translational Medicine

In Vivo Intrathecal Tracer Dispersion in Cynomolgus Monkey Validates Wide Biodistribution Along Neuraxis

(2019) Kevin Tangen et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

On the bulk motion of the cerebrospinal fluid in the spinal canal

(2018) A. L. Sánchez et al.   JOURNAL OF FLUID MECHANICS

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

(2018) Per Kristian Eide et al.   Scientific Reports

Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge

(2018) Kristian Valen-Sendstad et al.   Cardiovascular Engineering and Technology

Market access of Spinraza (Nusinersen) for spinal muscular atrophy: intellectual property rights, pricing, value and coverage considerations

(2017) S Simoens et al.   GENE THERAPY

Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI

(2017) Selda Yildiz et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Spinal Cord Injury During Attempted Cervical Interlaminar Epidural Injection of Steroids

(2017) Milton H Landers   PAIN MEDICINE

A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space

(2017) Per Thomas Haga et al.   PLoS One

Clearance of Subarachnoid Hemorrhage from the Cerebrospinal Fluid in Computational and In Vitro Models

(2016) K. Tangen et al.   ANNALS OF BIOMEDICAL ENGINEERING

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

(2015) Kevin M. Tangen et al.   JOURNAL OF BIOMECHANICS

Improving Single Injection CSF Delivery of AAV9-mediated Gene Therapy for SMA: A Dose–response Study in Mice and Nonhuman Primates

(2015) Kathrin Meyer et al.   MOLECULAR THERAPY

$1-million price tag set for Glybera gene therapy

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

Clinical Relevance of Pharmacological and Physiological Data in Intrathecal Baclofen Therapy

(2014) Herre W. Heetla et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Effects of fluid structure interaction in a three dimensional model of the spinal subarachnoid space

(2014) Shaokoon Cheng et al.   JOURNAL OF BIOMECHANICS

Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

(2013) S J Gray et al.   GENE THERAPY

Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

(2013) Mikhail I. Papisov et al.   MOLECULAR PHARMACEUTICS

The Frequency and Magnitude of Cerebrospinal Fluid Pulsations Influence Intrathecal Drug Distribution

(2012) &NA;   ANESTHESIA AND ANALGESIA

CNS Penetration of Intrathecal-Lumbar Idursulfase in the Monkey, Dog and Mouse: Implications for Neurological Outcomes of Lysosomal Storage Disorder

(2012) Pericles Calias et al.   PLoS One

Closure to “Discussion of ‘Factors of Safety for Richardson Extrapolation’ ” (2011, ASME J. Fluids Eng., 133, p. 115501)

(2011) Tao Xing et al.   JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

(2011) K. T. Al-Jamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics

(2010) Ryan G Soderquist et al.   Expert Opinion on Drug Delivery

Factors of Safety for Richardson Extrapolation

(2010) Tao Xing et al.   JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME

Understanding pharmacokinetics using realistic computational models of fluid dynamics: biosimulation of drug distribution within the CSF space for intrathecal drugs

(2010) Andreas Kuttler et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS