Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 379, Issue 4, Pages 939-943Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.12.176
Keywords
Apoptosis; Bax; TOM complex; Drosophila
Categories
Funding
- Association pour la Recherche contre le Cancer [3819]
- Ligue Nationale contre le Cancer (Comite des Yvelines)
- Ministere de la Recherche et de I'Enseignement Superieur
- Ecole Pratique des Hautes Etudes
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Bax is a pro-apoptotic member of the Bcl-2 family proteins involved in the release of apoptogenic factors from mitochondria to the cytosol. Recently, it has been shown both in mammals and yeast that Bax insertion in the mitochondrial outer membrane involves at least two distinct mechanisms, one of which uses the TOM complex. Here. we show that in Drosophila, heterozygous loss of function mutations of Tom22 or Tom70, two receptors of the TOM complex, attenuates bax-induced phenotypes in vivo. These results argue that the TOM complex may be used as a mitochondrial Bax receptor in Drosophila. (C) 2009 Elsevier Inc. All rights reserved.
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