RNA m6A Demethylase ALKBH5 Protects Against Pancreatic Ductal Adenocarcinoma via Targeting Regulators of Iron Metabolism

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

(2021) Ye Yuan et al.   Cell Death & Disease

RNA m6A Methylation Regulators Subclassify Luminal Subtype in Breast Cancer

(2021) Lin Yang et al.   Frontiers in Oncology

CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

(2021) Shi Chen et al.   Journal of Hematology & Oncology

YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect

(2021) Yichao Hou et al.   CELL DEATH AND DIFFERENTIATION

Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer

(2021) Donghong Zhang et al.   Cell Death & Disease

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

(2020) Bo Tang et al.   Molecular Cancer

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

(2020) Hui Wang et al.   MOLECULAR CELL

Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

(2020) Yangzom D. Bhutia et al.   Asian Journal of Pharmaceutical Sciences

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1.

(2020) Catherine L Carmichael et al.   BLOOD

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia

(2020) Chao Shen et al.   Cell Stem Cell

RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF‐ κ B pathway

(2020) Yi Jiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Iron: The cancer connection

(2020) Suzy V. Torti et al.   MOLECULAR ASPECTS OF MEDICINE

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

(2020) Xingya Guo et al.   Molecular Cancer

How Oxidation of a Unique Iron-Sulfur Cluster in FBXL5 Regulates IRP2 Levels and Promotes Regulation of Iron Metabolism Proteins

(2020) Tracey A. Rouault et al.   MOLECULAR CELL

Microenvironmental Determinants of Pancreatic Cancer

(2020) Elisabeth Hessmann et al.   PHYSIOLOGICAL REVIEWS

Pancreatic cancer

(2020) Jonathan D Mizrahi et al.   LANCET

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

(2020) Yunhao Chen et al.   Molecular Cancer

Iron and cancer: 2020 Vision

(2020) Suzy V. Torti et al.   CANCER RESEARCH

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

(2020) Min Wang et al.   Molecular Cancer

The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology

(2020) Edmund R. S. Kunji et al.   PHYSIOLOGY

SNAIL regulates gastric carcinogenesis through CCN3 and NEFL

(2020) Ru Chen et al.   CARCINOGENESIS

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

(2019) Yoshiharu Muto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

WT1 associated protein promotes metastasis and chemo-resistance to gemcitabine by stabilizing Fak mRNA in pancreatic cancer

(2019) Bing-Qi Li et al.   CANCER LETTERS

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

(2019) Junya Peng et al.   CELL RESEARCH

The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion

(2019) Tianfang Xia et al.   PATHOLOGY RESEARCH AND PRACTICE

The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling

(2019) Jinjin Yu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

(2019) Katherine I. Zhou et al.   MOLECULAR CELL

Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma

(2018) Alex Y L Lee et al.   GUT

Epitranscriptomic m 6 A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

(2018) Yi-Lan Weng et al.   NEURON

METTL3-mediated m6A modification is required for cerebellar development

(2018) Chen-Xin Wang et al.   PLOS BIOLOGY

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

(2018) Changfeng Li et al.   DEVELOPMENTAL CELL

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

(2018) Albrecht Neesse et al.   GUT

The role of the fat mass and obesity‑associated protein in the proliferation of pancreatic cancer cells

(2018) Xiaodong Tang et al.   Oncology Letters

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Our views of dynamic N 6 -methyladenosine RNA methylation

(2017) Boxuan Simen Zhao et al.   RNA

WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma

(2017) Bing-Qi Li et al.   Oncology Letters

Region-specific RNA m 6 A methylation represents a new layer of control in the gene regulatory network in the mouse brain

(2017) Mengqi Chang et al.   Open Biology

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FBXL5 Inhibits Metastasis of Gastric Cancer Through Suppressing Snail1

(2015) Weidong Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron

(2014) V Visconte et al.   LEUKEMIA

rMATS: Robust and flexible detection of differential alternative splicing from replicate RNA-Seq data

(2014) Shihao Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome-based analysis for RNA epigenome sequencing data

(2013) Jia Meng et al.   BIOINFORMATICS

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

(2013) R. Vinas-Castells et al.   NUCLEIC ACIDS RESEARCH

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo

(2011) Toshiro Moroishi et al.   Cell Metabolism

Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria

(2011) Yongming Wang et al.   EXPERIMENTAL HEMATOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH