Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells

(2021) Carsten Riether et al.   Cell Reports

Successful treatment‐free remission in chronic myeloid leukaemia and its association with reduced immune suppressors and increased natural killer cells

(2020) Yazad D. Irani et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10

(2020) Virginia Camacho et al.   JCI Insight

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Chronic myeloid leukemia stem cells

(2019) Mohammad Houshmand et al.   LEUKEMIA

Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial

(2018) Jorge E. Cortes et al.   BLOOD

CD150 high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

(2018) Yuichi Hirata et al.   Cell Stem Cell

Immune cell contexture in the bone marrow tumor microenvironment impacts therapy response in CML

(2018) Oscar Brück et al.   LEUKEMIA

Regulatory T cell inhibition by dasatinib is associated with natural killer cell differentiation and a favorable molecular response—The final results of the D-first study

(2018) Yuho Najima et al.   LEUKEMIA RESEARCH

The HLA ligandome landscape of chronic myeloid leukemia delineates novel T-cell epitopes for immunotherapy

(2018) Tatjana Bilich et al.   BLOOD

Immune Effector Recovery in Chronic Myeloid Leukemia and Treatment-Free Remission

(2017) Amy Hughes et al.   Frontiers in Immunology

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression

(2016) Anuradha Tarafdar et al.   BLOOD

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells

(2016) B. Zhang et al.   BLOOD

How Do Cytotoxic Lymphocytes Kill Cancer Cells?

(2015) L. Martinez-Lostao et al.   CLINICAL CANCER RESEARCH

Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells

(2015) Luke S. Manlove et al.   JOURNAL OF IMMUNOLOGY

Blocking programmed cell death 1 in combination with adoptive cytotoxic T-cell transfer eradicates chronic myelogenous leukemia stem cells

(2015) C Riether et al.   LEUKEMIA

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Concomitant analysis of Helios and Neuropilin-1 as a marker to detect thymic derived regulatory T cells in naïve mice

(2015) Kailash Singh et al.   Scientific Reports

Regulation of hematopoietic and leukemic stem cells by the immune system

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Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy

(2014) Yannick Bulliard et al.   IMMUNOLOGY AND CELL BIOLOGY

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

(2014) Yuki Kagoya et al.   JOURNAL OF CLINICAL INVESTIGATION

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Autocrine TNF-  production supports CML stem and progenitor cell survival and enhances their proliferation

(2013) P. Gallipoli et al.   BLOOD

Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: results from the TWISTER study

(2013) D. M. Ross et al.   BLOOD

Evaluation of monocyte-derived dendritic cells, T regulatory and Th17 cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

(2013) Iwona Hus et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Prognostic value of regulatory T cells in newly diagnosed chronic myeloid leukemia patients

(2013) Asmaa M. Zahran et al.   International Journal of Clinical Oncology

Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ

(2013) Christian Schürch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients

(2013) Hans-Henning Schmidt et al.   OncoImmunology

CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression

(2012) Christian Schürch et al.   JOURNAL OF CLINICAL INVESTIGATION

Nilotinib vs imatinib in patients with newly diagnosed Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: ENESTnd 3-year follow-up

(2012) R A Larson et al.   LEUKEMIA

Quantitative and functional analyses of CD4+CD25+FoxP3+ regulatory T cells in chronic phase chronic myeloid leukaemia patients at diagnosis and on imatinib mesylate

(2011) Emmanuel Bachy et al.   BRITISH JOURNAL OF HAEMATOLOGY

Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial

(2011) Hagop M Kantarjian et al.   LANCET ONCOLOGY

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

Naturally occurring CD4+ CD25+ FOXP3+ T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive

(2010) Jose M. Rojas et al.   EXPERIMENTAL HEMATOLOGY

Regulation of Granulocyte and Macrophage Populations of Murine Bone Marrow Cells by G-CSF and CD137 Protein

(2010) Dongsheng Jiang et al.   PLoS One

Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression

(2009) S. Mumprecht et al.   BLOOD

The CD4+ T-Cell Response of Melanoma Patients to a MAGE-A3 Peptide Vaccine Involves Potential Regulatory T Cells

(2009) V. Francois et al.   CANCER RESEARCH

Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support

(2008) Paul A. Harris et al.   JOURNAL OF BIOMEDICAL INFORMATICS

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells

(2008) Seung-Woo Lee et al.   NATURE IMMUNOLOGY