Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis

Myofibroblast YAP/TAZ is dispensable for liver fibrosis in mice

(2021) Liran Xu et al.   JOURNAL OF HEPATOLOGY

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

YAP Activation in Renal Proximal Tubule Cells Drives Diabetic Renal Interstitial Fibrogenesis

(2020) Jianchun Chen et al.   DIABETES

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

(2020) Sarah Alsamman et al.   Science Translational Medicine

YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction

(2020) Masum M. Mia et al.   PLOS BIOLOGY

Yap/Taz regulate alveolar regeneration and resolution of lung inflammation

(2019) Ryan LaCanna et al.   JOURNAL OF CLINICAL INVESTIGATION

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblastsin Liver Fibrosis

(2019) Oliver Krenkel et al.   Cells

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis

(2019) Yang Xiao et al.   GENES & DEVELOPMENT

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Deregulation of Hippo–TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

(2018) Sandybell Anorga et al.   FASEB JOURNAL

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

Activation of human aortic valve interstitial cells by local stiffness involves YAP-dependent transcriptional signaling

(2018) Rosaria Santoro et al.   BIOMATERIALS

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

(2018) Ye Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β1 regulates the expression and transcriptional activity of TAZ protein via a Smad3-independent, myocardin-related transcription factor-mediated mechanism

(2017) Maria Zena Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis

(2017) Ming Liang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

(2017) Satoshi Noguchi et al.   Scientific Reports

The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology

(2016) A. Loupy et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation

(2016) Helen McNeill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recombinant N-Terminal Slit2 Inhibits TGF- -Induced Fibroblast Activation and Renal Fibrosis

(2016) D. A. Yuen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis

(2016) S. G. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

(2016) Eunjeong Seo et al.   Scientific Reports

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

(2015) Bram Piersma et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney

(2015) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Cytoskeletal Tension Inhibits Hippo Signaling through an Ajuba-Warts Complex

(2014) Cordelia Rauskolb et al.   CELL

Next-generation RNA Sequencing of Archival Formalin-fixed Paraffin-embedded Urothelial Bladder Cancer

(2014) Yu Liu et al.   EUROPEAN UROLOGY

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Slit2 Prevents Neutrophil Recruitment and Renal Ischemia-Reperfusion Injury

(2013) S. Chaturvedi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Early outgrowth cells release soluble endocrine antifibrotic factors that reduce progressive organ fibrosis

(2013) Darren A. Yuen et al.   STEM CELLS

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

(2013) Antoine Reginensi et al.   PLoS Genetics

Early-Outgrowth Bone Marrow Cells Attenuate Renal Injury and Dysfunction via an Antioxidant Effect in a Mouse Model of Type 2 Diabetes

(2012) Y. Zhang et al.   DIABETES

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism

(2010) Darren A. Yuen et al.   PLoS One

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils

(2009) Soumitra Tole et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

(2008) Leon G. Fine et al.   KIDNEY INTERNATIONAL

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

The bleomycin animal model: A useful tool to investigate treatment options for idiopathic pulmonary fibrosis?

(2007) Antje Moeller et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY