Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

(2021) Ayse Bassez et al.   NATURE MEDICINE

Normal tissue architecture determines the evolutionary course of cancer

(2021) Jeffrey West et al.   Nature Communications

Genomic profile of advanced breast cancer in circulating tumour DNA

(2021) Belinda Kingston et al.   Nature Communications

Selection of metastasis competent subclones in the tumour interior

(2021) Yue Zhao et al.   Nature Ecology & Evolution

Mapping the breast cancer metastatic cascade onto ctDNA using genetic and epigenetic clonal tracking

(2020) George D. Cresswell et al.   Nature Communications

When, why and how tumour clonal diversity predicts survival

(2020) Robert Noble et al.   Evolutionary Applications

Characterizing the ecological and evolutionary dynamics of cancer

(2020) Nastaran Zahir et al.   NATURE GENETICS

Mechanics of a multilayer epithelium instruct tumour architecture and function

(2020) Vincent F. Fiore et al.   NATURE

Pervasive chromosomal instability and karyotype order in tumour evolution

(2020) Thomas B. K. Watkins et al.   NATURE

Prostate cancer evolution from multilineage primary to single lineage metastases with implications for liquid biopsy

(2020) D. J. Woodcock et al.   Nature Communications

Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing

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Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Intratumor Heterogeneity and Circulating Tumor Cell Clusters

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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Between-region genetic divergence reflects the mode and tempo of tumor evolution

(2017) Ruping Sun et al.   NATURE GENETICS

Tracking the Evolution of Non–Small-Cell Lung Cancer

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Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

(2016) Rouven Hoefflin et al.   Nature Communications

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma

(2015) Jingtao Peng et al.   CANCER LETTERS

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

(2015) Bartlomiej Waclaw et al.   NATURE

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

(2015) Lucy R Yates et al.   NATURE MEDICINE

Spatial evolution of tumors with successive driver mutations

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Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

(2015) Linda Holmquist Mengelbier et al.   Nature Communications

Tracking the Genomic Evolution of Esophageal Adenocarcinoma through Neoadjuvant Chemotherapy

(2015) N. Murugaesu et al.   Cancer Discovery

Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy

(2014) M. H. Voss et al.   CLINICAL CANCER RESEARCH

Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

(2014) Dejan Juric et al.   NATURE

The Model Muddle: In Search of Tumor Growth Laws

(2013) P. Gerlee   CANCER RESEARCH

Tumor growth dynamics: insights into evolutionary processes

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE