Article
Chemistry, Applied
Florencia Fatima Ferramola, Carla Marrassini, Maria Rosario Alonso, Maria Aida Mattar Dominguez, Alba Edith Vega, Claudia Anesini
Summary: This study revealed that an aqueous extract of O. vulgare exhibited antioxidant activities and immunomodulatory properties. The extract showed superoxide dismutase and peroxidase-like activities with concentration-dependent effects. Furthermore, the extract was able to modulate the production of nitric oxide in macrophages, exerting both anti-inflammatory and pro-inflammatory effects.
NATURAL PRODUCT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Thais Latansio de Oliveira, Lorena Bavia, Pamela Dias Fontana, Luiza Stolz Cruz, Katia Sabrina Paludo, Amanda Rabello Crisma, Iara Jose Messias-Reason, Flavio Luis Beltrame
Summary: Euphol isolated from Euphorbia umbellata latex showed regulatory effects on different complement pathways and affected neutrophil chemotaxis and cytotoxic activity in cell experiments. It also demonstrated the ability to induce cell death in a time-dependent manner.
Article
Nutrition & Dietetics
Jiaqi Zhu, Jing Li, Yiting Guo, Janet Quaisie, Chen Hong, Haile Ma
Summary: The study found that DCGHs have antihypertensive and immunomodulatory effects, potentially achieved through regulating blood pressure balance and enhancing macrophage immune activity.
FRONTIERS IN NUTRITION
(2021)
Article
Infectious Diseases
Amy E. Bryant, Dennis L. Stevens
Summary: Omadacycline has unique and broad immunomodulatory properties and can suppress the production of cytokines, alleviate cytokine-mediated tissue injury, and improve outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Lei Zheng, XingYi Zhu, Jialu Wang, Weike Su
Summary: The study developed mechanochemical-assisted extraction (MCAE) and mechanochemical-assisted enzyme catalysis (MCAEC) methods for extracting and enzymatic hydrolysis of calcium phytate from defatted rice bran, respectively. The optimized MCAE conditions resulted in a calcium phytate yield of 97.0 mg/g, while the optimized MCAEC conditions achieved a hydrolysis rate of 39.7% for calcium phytate. Compared to traditional methods, MCAE and MCAEC demonstrated higher yields and hydrolysis rates, respectively.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Food Science & Technology
Lambros Sakkas, Eleni Lekaki, Golfo Moatsou
Summary: Tryptic WPHs with considerable residual whey protein content were developed without pH control. The hydrolysis process and storage did not significantly affect the pH. The degree and extent of hydrolysis were determined, and the biofunctional activities of the hydrolysates were evaluated.
Article
Microbiology
Xiaoran Wang, Jilang Tang, Shixia Zhang, Nuannuan Zhang
Summary: The study demonstrates that Lactiplantibacillus plantarum 19-2 improves the immune function of mice treated with cyclophosphamide, regulates the distribution of intestinal flora, promotes the growth of beneficial bacteria, and inhibits the growth of harmful bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Chaoya Zhao, Yurong Gong, Lin Zheng, Mouming Zhao
Summary: The aim of this study was to examine the effects of whey protein hydrolysates (WPHs) characteristics on energy metabolism in exercise mice. The results showed that high-degree of hydrolysis (DH) hydrolysates had better anti-fatigue effects and regulated energy balance by activating certain pathways. H-Alc contained essential amino acids that decreased protein metabolites, while H-AXH promoted glucose consumption in muscle due to its high content of free amino acid Leu.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Feiyue Ren, Yulin Feng, Huijuan Zhang, Jing Wang
Summary: This study examined the effects of different modification methods on defatted rice bran dietary fiber, with fermentation and enzymatic hydrolysis combined modification showing the most significant impact. The microstructural properties of the modified dietary fiber changed, while the crystal type remained generally unchanged. Glucose adsorption capacity was significantly improved with fermentation and enzymatic hydrolysis modification.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Eliana Isabel Fernandez Sosa, Maria Guadalupe Chaves, Alejandra Viviana Quiroga, Maria Victoria Avanza
Summary: Pigeon pea protein isolates (PPI) offer the potential for high yield of quality proteins in the food industry. The study compared the physicochemical and structural properties of albumin (ALB), globulin (GLB), and PPI at different pH levels, showing that the pH variation in protein extraction can affect the functional properties of PPI.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Plant Sciences
Monu Kumar Shukla, Sachin Kumar Singh, Sadanand Pandey, Piyush Kumar Gupta, Anurag Choudhary, Deepak Kumar Jindal, Kamal Dua, Deepak Kumar
Summary: The immune system is crucial for defending the body against infections and diseases. Immunomodulators play a vital role in balancing the immune system by either stimulating or suppressing immune responses as needed for treatment. Plant-derived compounds, such as curcumin, resveratrol, epigallocatechin-3-gallate, andrographolide, and genistein, have shown potential as immunomodulators. This review provides an overview of these plant-derived metabolites and their effects on the immune system.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Food Science & Technology
Kartik Sharma, Krisana Nilsuwan, Bin Zhang, Hui Hong, Soottawat Benjakul
Summary: This study investigated the effects of plastein reaction on the bitterness, physicochemical properties, and antioxidant activity of salmon frame hydrolysate using different proteases at varying concentrations and temperatures. The results showed that the plastein reaction significantly reduced the bitterness of the hydrolysate and improved its solubility, although there was a slight decrease in antioxidant activity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Athina Trakaki, Gunther Marsche
Summary: HDL, a lipoprotein rich in anti-inflammatory lipids, reduces inflammation and protects against infection by modulating immune cell function and endothelial barrier function.
Article
Biochemistry & Molecular Biology
Feng Liu, Ying Liu, Xi Feng, Salam A. Ibrahim, Wen Huang
Summary: Carboxymethyl pachymaran (CMP) was prepared from Poria cocos polysaccharide by carboxymethylation, resulting in two types of CMP (CMP-1 and CMP-2) with immunomodulatory activities. Both CMP-1 and CMP-2 contain a beta-(1 -> 3)-D-glucan structure that can promote macrophage activity, with CMP-1 exhibiting stronger immunomodulatory ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Li Ren, Jie Zhang, Tiehua Zhang
Summary: Polysaccharides from Ganoderma, as the most abundant bioactive compounds, exhibit unique biological properties such as anti-tumor, anti-inflammatory, and immunomodulatory activities. They can potentially be applied for the modulation of the host immune system, including innate immunity, cellular immunity, and humoral immunity.
Article
Biochemistry & Molecular Biology
Qiping Zhan, Qian Wang, Ruge Lin, Ping He, Furao Lai, Mengmeng Zhang, Hui Wu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Applied
Fanke Zeng, Wenbo Chen, Ping He, Qiping Zhan, Qian Wang, Hui Wu, Mengmeng Zhang
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Zhou Dong, Yanyin Lin, Hui Wu, Mengmeng Zhang
Summary: This study successfully enriched selenium in Tenebrio molitor larvae, increasing the total selenium content and discovering the presence of organic selenium. Selenium was unevenly distributed in protein fractions, and the protein hydrolysate of selenium-enriched larvae exhibited strong antioxidant and immunoregulatory activities after hydrolysis.
Article
Biotechnology & Applied Microbiology
Lisha Hao, Mengmeng Zhang, Xiaofeng Li, Xuan Xin, Faling Lei, Xueneng Lai, Guanglei Zhao, Hui Wu
Summary: Esculin, a polyphenol with poor lipophilicity, was successfully acylated using a whole-cell catalytic strategy to improve its properties. Various esculin esters with different fatty chain lengths were synthesized, with some exhibiting cytotoxicity on cells. This study offers insight into the potential applications of esculin esters as food additives or drugs.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Mengmeng Zhang, Xuan Xin, Hui Wu, Hong Zhang
Summary: Proteases extracted from soybean seedlings germinated on the sixth day showed the highest activity and were able to effectively reduce the bitterness of soybean protein hydrolysates without compromising their antioxidant activity.
Article
Chemistry, Applied
Qi Liu, Qian Wang, Ping He, Yi Zhang, Leiman Pan, Yong Chen, Hui Wu, Mengmeng Zhang
Summary: The study showed that selenium enrichment improved the gel properties and digestive products of egg white, with selenium-enriched egg white exhibiting higher gel strength and antioxidant activity compared to ordinary egg white.
Article
Biochemistry & Molecular Biology
Wenbo Chen, Xiaolu Zhu, Lei Wang, Xuan Xin, Mengmeng Zhang
Summary: In this study, the effects of two polysaccharides (MC-1 and MC-2) found in maca roots on intestinal immunity and inflammation were investigated. The results showed that these polysaccharides activated intestinal immunity and alleviated intestinal inflammation in vitro. Additionally, they promoted the secretion of certain cytokines while inhibiting the secretion of inflammatory factors.
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Xuan Xin, Guanglei Zhao, Yucong Zou, Xiao-Feng Li
Summary: By synthesizing ester derivatives, the lipophilicity and lipid-lowering activity of baicalin were improved. These esters showed better absorption and lipid-lowering effects in cell models, but were easily hydrolyzed and unstable under neutral conditions.
BIOORGANIC CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Ping He, Leiman Pan, Hui Wu, Lina Zhang, Yi Zhang, Yizhe Zhang, Jinxi Yang, Zhengli Lin, Mengmeng Zhang
Summary: This study demonstrates that the hydrolysate of Maca protein enhances the immunomodulatory activity in macrophages and identifies the peptide RNPFLP as the most potent immunomodulatory peptide in the hydrolysate. Experimental evidence shows that RNPFLP activates macrophages through the NF-Kappa B and MAPK signaling pathways mediated by TLR2 and TLR4 receptors. Furthermore, the study reveals the important role of the N9-H60 active site in arginine in the immunomodulatory activity of RNPFLP.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Yangwei Shan, Chongzhen Sun, Jishan Li, Xin Shao, Junfeng Wu, Mengmeng Zhang, Hong Yao, Xiyang Wu
Summary: Mulberry leaf protein has antioxidant and anti-inflammatory properties, and can alleviate immunosuppression by modulating gut microbiota and immune response, making it a promising dietary supplement for maintaining gut health.
Article
Food Science & Technology
Zhengli Lin, Junwen Lai, Ping He, Leiman Pan, Yizhe Zhang, Mengmeng Zhang, Hui Wu
Summary: In this study, six novel ACE inhibitor peptides were identified in maca protein hydrolysates, and RSRGVFF exhibited prominent ACE inhibitory activity. The analysis of the structure-activity relationship revealed that arginine at the N-terminal and two phenylalanines at the C-terminal contributed to the inhibitory activity. These findings suggest that maca protein may play a role in the antihypertensive activity.
Article
Food Science & Technology
Ping He, Mengmeng Zhang, Yizhe Zhang, Hui Wu, Xiaoyuan Zhang
Summary: In this research, the effect of selenium enrichment on dough fermentation characteristics of yeast was studied. It was found that selenium enrichment increased the CO2 production and sugar consumption rate of Saccharomyces cerevisiae in dough fermentation, leading to improved final volume and rheological index of dough. Moreover, using selenium-enriched yeast as a starter resulted in selenium-enriched bread with higher overall acceptability, better texture properties, and increased cell density in stomatal morphology.
Article
Food Science & Technology
Yizhe Zhang, Ping He, Leiman Pan, Zhengli Lin, Jinxi Yang, Hui Wu, Mengmeng Zhang
Summary: This study revealed the immunological impact of earthworm protein autolysate on immunosuppressed mice model and identified and evaluated its active peptides, providing a potential resource for immunomodulatory peptides.
Article
Biochemistry & Molecular Biology
Ping He, Yizhe Zhang, Ruyang Chen, Zhaoli Tong, Mengmeng Zhang, Hui Wu
Summary: This study found that Maca protein can alleviate inflammatory bowel disease (IBD) by modulating the gut microbiota and inflammatory response. It improves disease symptoms and tissue damage, and promotes the production of short-chain fatty acids. It regulates the immune balance through the SCFAs-GPR41/43/HDAC1 signaling pathway.
Article
Biochemistry & Molecular Biology
Ping He, Qian Wang, Qiping Zhan, Leiman Pan, Xuan Xin, Hui Wu, Mengmeng Zhang
Summary: Duck egg white (DEW) is explored as a source of immunomodulatory peptides, with papain hydrolysate (PH) showing high hydrolysis degree and strong activity. Among the nine identified peptides, five exhibit strong activity, with TQIDKVVHFDKLPGF peptide showing the highest immunomodulatory activity. Molecular docking results suggest good affinity between these peptides and toll-like receptor 2 and 4, with three selected peptides forming stable bonds contributing to their immune activity.
