Single site mutations of glycosyltransferase with improved activity and regioselectivity for directed biosynthesis of unnatural protopanaxatriol-type ginsenoside product

High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae

(2021) Xiaodong Li et al.   METABOLIC ENGINEERING

Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis

(2020) Bing Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Oriented efficient biosynthesis of rare ginsenoside Rh2 from PPD by compiling UGT-Yjic mutant with sucrose synthase

(2019) Wang Ma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

One-Pot Synthesis of Ginsenoside Rh2 and Bioactive Unnatural Ginsenoside by Coupling Promiscuous Glycosyltransferase from Bacillus subtilis 168 to Sucrose Synthase

(2018) Longhai Dai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Use of a Promiscuous Glycosyltransferase from Bacillus subtilis 168 for the Enzymatic Synthesis of Novel Protopanaxatriol-Type Ginsenosides

(2018) Longhai Dai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis : synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells

(2018) Dan-Dan Wang et al.   Journal of Ginseng Research

Structure-guided engineering of meso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids

(2018) Xinkuan Cheng et al.   Catalysis Science & Technology

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies

(2018) Weijie Xie et al.   Cells

Exploiting the aglycon promiscuity of glycosyltransferase Bs-YjiC from Bacillus subtilis and its application in synthesis of glycosides

(2017) Longhai Dai et al.   JOURNAL OF BIOTECHNOLOGY

Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme

(2017) Yu Zhuang et al.   METABOLIC ENGINEERING

A Metabolomic Approach for the Discrimination of Red Ginseng Root Parts and Targeted Validation

(2017) Gyo In et al.   MOLECULES

Biosynthesis of rare 20( R )-protopanaxadiol/protopanaxatriol type ginsenosides through Escherichia coli engineered with uridine diphosphate glycosyltransferase genes

(2017) Lu Yu et al.   Journal of Ginseng Research

Biosynthesis and biotechnological production of ginsenosides

(2015) Yu-Jin Kim et al.   BIOTECHNOLOGY ADVANCES

Enzymatic transformation of ginsenoside Rb1 to ginsenoside 20(S)-Rg3 by GH3 β-glucosidase from Thermotoga thermarum DSM 5069T

(2015) Jianjun Pei et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Characterization of Panax ginseng UDP-Glycosyltransferases Catalyzing Protopanaxatriol and Biosyntheses of Bioactive Ginsenosides F1 and Rh1 in Metabolically Engineered Yeasts

(2015) Wei Wei et al.   Molecular Plant

Production of bioactive ginsenoside compound K in metabolically engineered yeast

(2014) Xing Yan et al.   CELL RESEARCH

Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus

(2013) JINGANG HOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats

(2012) Yusheng Gai et al.   TOXICOLOGY MECHANISMS AND METHODS

Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model

(2011) Fang Fang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere

(2009) Jian Yu et al.   BIOINFORMATICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Screening of anti-platelet aggregation agents fromPanax notoginsengusing human platelet extraction and HPLC-DAD-ESI-MS/MS

(2008) Jing Wang et al.   JOURNAL OF SEPARATION SCIENCE

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry