Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis

Brown adipose tissue is associated with cardiometabolic health

(2021) Tobias Becher et al.   NATURE MEDICINE

High Brown Fat Activity Correlates With Cardiovascular Risk Factor Levels Cross-Sectionally and Subclinical Atherosclerosis at 5-Year Follow-Up

(2020) Juho Raiko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice

(2020) Susanne Keipert et al.   Nature Communications

Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men

(2020) Masayuki Saito et al.   Frontiers in Endocrinology

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes

(2020) Kenji Ikeda et al.   Frontiers in Endocrinology

Origin and Function of Stress-Induced IL-6 in Murine Models

(2020) Hua Qing et al.   CELL

Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

(2020) Caryn Carson et al.   Cell Reports

UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice

(2020) Yuko Okamatsu-Ogura et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs

(2019) Min-Woo Lee et al.   Journal of Clinical Medicine

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Brown adipose cross talk in tissue plasticity and human metabolism

(2019) Camilla Scheele et al.   ENDOCRINE REVIEWS

New insights into the secretory functions of brown adipose tissue

(2019) Joan Villarroya et al.   JOURNAL OF ENDOCRINOLOGY

Association of circulating exosomal miR-122 levels with BAT activity in healthy humans

(2019) Yuko Okamatsu-Ogura et al.   Scientific Reports

Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption

(2018) Sally Winther et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

(2018) Mueez U Din et al.   Cell Metabolism

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

A 2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21

(2018) Cheng-Chao Ruan et al.   Cell Metabolism

Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice

(2018) Jae Hoon Jeong et al.   Scientific Reports

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

(2018) Xingxing Kong et al.   Cell Metabolism

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Brown Adipose Tissue Energy Metabolism in Humans

(2018) André C. Carpentier et al.   Frontiers in Endocrinology

Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice

(2017) Naresh C. Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men

(2017) K Alexander Iwen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose-derived circulating miRNAs regulate gene expression in other tissues

(2017) Thomas Thomou et al.   NATURE

UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis

(2017) Kenji Ikeda et al.   NATURE MEDICINE

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

The early metabolomic response of adipose tissue during acute cold exposure in mice

(2017) Xiyuan Lu et al.   Scientific Reports

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans

(2016) Kong Y. Chen et al.   Cell Metabolism

Brown adipose tissue is involved in diet-induced thermogenesis and whole-body fat utilization in healthy humans

(2016) M Hibi et al.   INTERNATIONAL JOURNAL OF OBESITY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-Mediated Pathway

(2016) Keigo Fukano et al.   PLoS One

Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle

(2016) Meghna Pant et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

(2016) Yong Chen et al.   Nature Communications

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice

(2015) Xiaomeng Liu et al.   ENDOCRINOLOGY

Brown Adipose Tissue Has Sympathetic-Sensory Feedback Circuits

(2015) V. Ryu et al.   JOURNAL OF NEUROSCIENCE

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

(2015) Mark J W Hanssen et al.   NATURE MEDICINE

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

(2015) Jimmy F. P. Berbée et al.   Nature Communications

Serum FGF21 levels are associated with brown adipose tissue activity in humans

(2015) Mark J.W. Hanssen et al.   Scientific Reports

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans

(2014) M. Chondronikola et al.   DIABETES

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans

(2014) Paul Lee et al.   DIABETES

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

(2014) Guo-Xiao Wang et al.   NATURE MEDICINE

Brown adipose tissue transplantation improves whole-body energy metabolism

(2013) Xiaomeng Liu et al.   CELL RESEARCH

Impact of brown adipose tissue on body fatness and glucose metabolism in healthy humans

(2013) M Matsushita et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature

(2013) Kong Y. Chen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

15O PET Measurement of Blood Flow and Oxygen Consumption in Cold-Activated Human Brown Fat

(2013) O. Muzik et al.   JOURNAL OF NUCLEAR MEDICINE

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

Thermogenic Ability of Uncoupling Protein 1 in Beige Adipocytes in Mice

(2013) Yuko Okamatsu-Ogura et al.   PLoS One

Differences in the metabolic status of healthy adults with and without active brown adipose tissue

(2013) Qiongyue Zhang et al.   WIENER KLINISCHE WOCHENSCHRIFT

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans

(2013) Masayuki Saito   Diabetes & Metabolism Journal

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

(2012) Miwako Nishio et al.   Cell Metabolism

Reversal of Type 1 Diabetes in Mice by Brown Adipose Tissue Transplant

(2012) S. C. Gunawardana et al.   DIABETES

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Impact of UCP1 and β3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans

(2012) T Yoneshiro et al.   INTERNATIONAL JOURNAL OF OBESITY

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)

(2012) Ajit S. Divakaruni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue

(2011) Elayne Hondares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2011) Dionysios Chartoumpekis et al.   MOLECULAR MEDICINE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Brown adipose tissue activity controls triglyceride clearance

(2011) Alexander Bartelt et al.   NATURE MEDICINE

Age-Related Decrease in Cold-Activated Brown Adipose Tissue and Accumulation of Body Fat in Healthy Humans

(2011) Takeshi Yoneshiro et al.   Obesity

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

(2010) Takeshi Yoneshiro et al.   Obesity

Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

(2009) Yuan Xue et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE