Article
Pharmacology & Pharmacy
Shuang Yin, Yan Wang, Bingyang Zhang, Yiran Qu, Yongdong Liu, Sheng Dai, Yao Zhang, Yingli Wang, Jingxiu Bi
Summary: The study involved the insertion of half-life extension peptide PAS and tumor targeting peptide RGDK into human heavy-chain ferritin, with results showing that the engineered ferritins can assemble into nanoparticles, with RGDK peptide enhancing internalization efficiency and growth inhibition against 4T1 cell line. In vivo pharmacokinetic study revealed that PAS peptides extended ferritin half-life about 4.9 times, while RGDK peptides greatly enhanced drug accumulation in the tumor site. Drug loaded PAS-RGDK functionalized HFns exhibited significantly greater efficacy in curbing tumor growth compared to drug loaded HFn.
Article
Biology
Bing Jiang, Xiaohua Jia, Tianjiao Ji, Meng Zhou, Jiuyang He, Kun Wang, Jie Tian, Xiyun Yan, Kelong Fan
Summary: The use of HFn nanoparticles and HFn-Dox drug delivery system enables early diagnosis and treatment of tumors, providing promising strategies for tumor therapy.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Rahul Rimal, Prachi Desai, Rasika Daware, Aisa Hosseinnejad, Jai Prakash, Twan Lammers, Smriti Singh
Summary: The tumor microenvironment, specifically cancer-associated fibroblasts (CAF), plays a critical role in tumor progression and drug resistance. This review presents imaging techniques for visualizing CAF and CAF-induced fibrosis, as well as compounds known to modulate CAF activity. Additionally, CAF-targeted therapies and CAF-modulating nanocarriers are discussed, along with the challenges and prospects for these treatments.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Engineering, Biomedical
Xue Zhou, Ning Yan, Erik J. Cornel, Haidong Cai, Shaobo Xue, Hao Xi, Zhen Fan, Shisheng He, Jianzhong Du
Summary: This bone-targeting polymer vesicle offers a new platform for the real-time diagnosis and therapy of malignant bone tumors, showing excellent imaging capability and high drug delivery efficiency. The vesicle can be self-assembled in water without the need for a cosolvent, and effectively reduces tumor size while inducing tumor cell necrosis and apoptosis.
Article
Chemistry, Multidisciplinary
Yongzhuo Huang
Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Roberta Giordo, Zena Wehbe, Panagiotis Paliogiannis, Ali H. Eid, Arduino A. Mangoni, Gianfranco Pintus
Summary: Tumor growth and progression are dependent on adequate blood supply. Tumor cells drive the formation of new blood vessels through the release of pro-angiogenic molecules. The processes involved in tumor angiogenesis are similar to normal vascular development, but with less control mechanisms. Targeting tumor blood vessels has been a focus of research, and nanomedicine offers advantages in specific drug delivery. This review comprehensively assesses key modulators of tumor vascular biology, promising nano-strategies, and future directions.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Luman Liu, Prakash G. Kshirsagar, Shailendra K. Gautam, Mansi Gulati, Emad Wafa, John C. Christiansen, Brianna M. White, Surya K. Mallapragada, Michael J. Wannemuehler, Sushil Kumar, Joyce C. Solheim, Surinder K. Batra, Aliasger K. Salem, Balaji Narasimhan, Maneesh Jain
Summary: Pancreatic tumors are difficult to treat due to their highly fibrotic and immunosuppressive nature. Nanotechnology offers promising solutions by providing improved drug delivery and immunotherapy-based approaches. This review highlights the potential of nanoscale strategies for treating pancreatic tumors and discusses future research directions.
Review
Pharmacology & Pharmacy
Lichun Cheng, Jiankun Yu, Tangna Hao, Wenshuo Wang, Minjie Wei, Guiru Li
Summary: This review article provides an extensive survey of recent progress in cancer immunotherapy strategies utilizing polymer micelles. These strategies include responsive and remodeling approaches to the tumor microenvironment, modulation of immunosuppressive cells, enhancement of immune checkpoint inhibitors, utilization of cancer vaccine platforms, manipulation of antigen presentation, manipulation of engineered T cells, and targeting other components of the tumor microenvironment. Polymer micelles demonstrate excellent prospects in tumor immunotherapy by effectively addressing the challenges associated with conventional cancer immunotherapies.
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Review
Oncology
Muhammad Abdur Rahim, Nasrullah Jan, Safiullah Khan, Hassan Shah, Asadullah Madni, Arshad Khan, Abdul Jabar, Shahzeb Khan, Abdelbary Elhissi, Zahid Hussain, Heather C. Aziz, Muhammad Sohail, Mirazam Khan, Hnin Ei Thu
Summary: This review focuses on improving the targeting of anticancer agents in the tumor microenvironment through stimuli-responsive drug delivery systems, discussing physical and chemical stimuli-responsive systems for active and passive targeting. Recent advancements in onco-targeted therapies have allowed for safe and effective tumor-specific localization, revolutionizing chemotherapy-based treatments with enhanced bioavailability and selective cytotoxicity.
Review
Chemistry, Multidisciplinary
Kuikun Yang, Shaoyi Zhang, Jie He, Zhihong Nie
Summary: The combination of inorganic nanoparticles and organic polymers in nanosized assemblies creates synergistically enhanced properties that hold great potential for cancer imaging and therapy.
Review
Pharmacology & Pharmacy
Abiodun Ayo, Pirjo Laakkonen
Summary: The article discusses a new treatment strategy utilizing tumor-targeting peptides to deliver drugs, as well as the structure-function relationship data of different tumor-targeting peptides. The importance of improving peptide activity and conjugation strategies is also highlighted.
Article
Biochemical Research Methods
Leopoldo Sitia, Valentina Galbiati, Arianna Bonizzi, Marta Sevieri, Marta Truffi, Mattia Pinori, Emanuela Corsini, Marina Marinovich, Fabio Corsi, Serena Mazzucchelli
Summary: Biological nanoparticles, such as proteins and extracellular vesicles, are being explored as nanobased drug-delivery agents due to their biocompatibility and high loading efficiency. However, the potential of these candidates in clinical trials is often not confirmed, partly due to the lack of control in synthesis processes and limited characterization of their immunoreactivity profiles. This study demonstrates the importance of evaluating the immunoreactivity of nanodrugs, using H-ferritin nanoparticles as an example, and highlights the need for combined analysis of acute toxicity and immunoreactivity to ensure the safety and translational potential of newly developed nanodrugs.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Oncology
Andrea Vittorio Emanuele Lisa, Marzia Salgarello, Alessandra Huscher, Fabio Corsi, Daniele Piovani, Federica Rubbino, Stefania Andreoletti, Giovanni Papa, Francesco Klinger, Corrado Tinterri, Alberto Testori, Marta Scorsetti, Paolo Veronesi, Maria Cristina Leonardi, Mario Rietjens, Umberto Cortinovis, Valeria Summo, Emanuele Rampino Cordaro, Pier Camillo Parodi, Paolo Persichetti, Mauro Barone, Giorgio De Santis, Matteo Murolo, Michele Riccio, Angelica Aquinati, Francesco Cavaliere, Nicola Vaia, Giulia Pagura, Erica Dalla Venezia, Franco Bassetto, Vincenzo Vindigni, Luigi Ciuffreda, Maria Alessandra Bocchiotti, Alberto Sciarillo, Nadia Renzi, Graziano Meneghini, Tajna Kraljic, Andrea Loreti, Lucio Fortunato, Valentina Pino, Valeriano Vinci, Marco Klinger
Summary: In this national multicenter study, the impact of postmastectomy radiotherapy (PMRT) on breast reconstruction was analyzed. The study found that patients receiving PMRT had a significantly increased risk of complications, especially capsular contracture in direct-to-implant (DTI) and tissue expander/immediate (TE/I) reconstruction. Autologous reconstruction was found to be the least impacted by PMRT.
Article
Computer Science, Interdisciplinary Applications
Alessia Gerbasi, Greta Clementi, Fabio Corsi, Sara Albasini, Alberto Malovini, Silvana Quaglini, Riccardo Bellazzi
Summary: Breast cancer is the most prevalent form of cancer worldwide, and microcalcifications are the earliest detectable sign of breast cancer. However, the detection and classification of microcalcifications are still challenging. In this study, we propose a fully automated and visually explainable deep-learning based pipeline, DeepMiCa, for the analysis of mammograms with microcalcifications. Our aim is to provide a reliable decision support system for diagnosis and help clinicians inspect difficult cases.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Endocrinology & Metabolism
Federica Ferrari, Daniela Rossi, Alessandra Ricciardi, Carlo Morasso, Liliana Brambilla, Sara Albasini, Renzo Vanna, Chiara Fassio, Tatjana Begenisic, Marianna Loi, Daniela Bossi, Alberto Zaliani, Elisa Alberici, Claudio Lisi, Andrea Morotti, Anna Cavallini, Federico Mazzacane, Antonio Nardone, Fabio Corsi, Marta Truffi
Summary: This study aimed to measure the serum levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in stroke patients and evaluate their correlation with functional outcome and rehabilitation scores. The results showed that serum NfL and GFAP levels were positively correlated with clinical/rehabilitation outcomes, with NfL being the best predictor.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Surgery
Fabio Corsi, Sara Albasini, Simone Ciciriello, Laura Villani, Marta Truffi, Marta Sevieri, Luca Sorrentino
Summary: This study aimed to assess the impact of extensive intraductal component (EIC) on 5-year survival outcomes in patients with early breast cancer treated with breast-conserving surgery. The results showed that the absence of EIC was associated with worse 5-year disease-free survival (DFS) and distant metastasis-free survival (DMFS). EIC increased 5-year DFS in T1 patients but not in T2 stage, and it was associated with better DFS in G2 and G3 patients but not in G1 cases.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Marta Truffi, Maria Garofalo, Alessandra Ricciardi, Matteo Cotta Ramusino, Giulia Perini, Silvia Scaranzin, Matteo Gastaldi, Sara Albasini, Alfredo Costa, Viola Chiavetta, Fabio Corsi, Carlo Morasso, Stella Gagliardi
Summary: Neurofilament light chains (NfL), neuron-specific cytoskeletal proteins, have been explored as a useful marker in various types of dementia. The plasma levels of NfL were studied using SiMoA and Ella platforms, which showed a correlation and potential for neurodegeneration diagnosis.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Marta Sevieri, Mattia Pinori, Arianna Chesi, Arianna Bonizzi, Leopoldo Sitia, Marta Truffi, Carlo Morasso, Fabio Corsi, Serena Mazzucchelli
Summary: Due to its unique architecture and specific targeting ability, ferritin is an attractive biomaterial for drug delivery. Chemotherapeutics have been loaded into ferritin nanocages and their antitumor efficacy has been explored. However, there are challenges for the clinical translation of ferritin as drug carriers. This review summarizes the efforts to maximize the features of ferritin and improve its stability and in vivo circulation.
Article
Pharmacology & Pharmacy
Marta Sevieri, Serena Mazzucchelli, Linda Barbieri, Stefania Garbujo, Stephana Carelli, Arianna Bonizzi, Federica Rey, Camilla Recordati, Matteo Recchia, Raffaele Allevi, Leopoldo Sitia, Carlo Morasso, Pietro Zerbi, Davide Prosperi, Fabio Corsi, Marta Truffi
Summary: The study demonstrates the potential of a nanoconjugate called H-TZ, consisting of TZ and HFn, in delivering TZ to the brain and combating HER2+ breast cancer brain metastasis. H-TZ efficiently reduces tumor growth, avoids cardiotoxicity, and shows promise for managing BC metastatic to the brain.
PHARMACOLOGICAL RESEARCH
(2023)
Letter
Oncology
Carlo Morasso, Renzo Vanna, Francesca Piccotti, Lidia Frizzi, Marta Truffi, Sara Albasini, Camelia Borca, Thomas Huthwelker, Laura Villani, Oliver Bunk, Cinzia Giannini, Fabio Corsi
CANCER COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Serena Mazzucchelli, Francesco Mainini, Francesco Andreata, Marta Truffi, Arianna Bonizzi, Francesca Piccotti, Marta Sevieri, Fabio Corsi
Article
Chemistry, Analytical
Arianna Bonizzi, Flavia Magri, Serena Mazzucchelli, Marta Truffi, Andrea Rizzi, Fabio Corsi, Roberta Cazzola, Carlo Morasso
Summary: Lipoproteins play a crucial role in transporting fatty acids, cholesterol, and micronutrients through the body. Recent studies have highlighted the importance of assessing the overall quality of lipoproteins, including their biochemical composition and oxidation state, in determining cardiovascular risk. This research demonstrates the effectiveness of Raman spectroscopy in quickly detecting the biochemical components and unsaturated lipid levels in lipoproteins, as well as revealing differences in composition and oxidation state between obese patients and a control group. The study also establishes the relationship between carotenoid levels in different classes of lipoproteins and disease severity.
