Article
Genetics & Heredity
Tie-Ning Zhang, Ri Wen, Yu-Hang Yang, Ni Yang, Chun-Feng Liu
Summary: In this study, the association between lncRNA rPvt1 and lipopolysaccharide-induced cardiomyocyte injury was explored using transcriptomic, proteomic, and metabolomic assays. The results revealed that rPvt1 knockdown led to significant changes in the transcriptome, proteome, and metabolome, indicating its important role in septic myocardial dysfunction. Functional annotation and pathway analyses suggested that mitochondrial energy metabolism might be closely related to the mechanism through which Pvt1 functions.
FRONTIERS IN GENETICS
(2023)
Article
Clinical Neurology
Dominique F. Leitner, Yik Siu, Aryeh Korman, Ziyan Lin, Evgeny Kanshin, Daniel Friedman, Sasha Devore, Beatrix Ueberheide, Aristotelis Tsirigos, Drew R. Jones, Thomas Wisniewski, Orrin Devinsky
Summary: High-fat and low-carbohydrate diets, such as the modified Atkins diet (MAD), can reduce seizure frequency in treatment-resistant epilepsy patients. These diets mimic fasting and induce high levels of ketone bodies, potentially shifting brain energy production and impacting neuronal and astrocyte metabolism.
Review
Plant Sciences
Xiangyu Xu, Cassio Flavio Fonseca de Lima, Lam Dai Vu, Ive De Smet
Summary: Changes in weather patterns, drought risks, and rising global temperature negatively impact crop growth and productivity. Plants are exposed to multiple stresses simultaneously, but most studies focus on individual stress conditions. This mini-review focuses on the combination of drought and heat, summarizing current research results, identifying knowledge gaps, and suggesting potential future focus areas.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Oncology
Zijian Zou, Wei Sun, Yu Xu, Wanlin Liu, Jingqin Zhong, Xinyi Lin, Yong Chen
Summary: Sarcomas are rare mesenchymal neoplasms with unique genetic characteristics, and their diagnosis relies heavily on pathological examination. Advanced treatments and multi-omics approaches have shown promise in improving outcomes and understanding sarcomas, but further research is needed to optimize their clinical application.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Alexander Arsov, Kaloyan Petrov, Penka Petrova
Summary: This article discusses the potential of microbial production of butanol as a new fuel and the challenge of butanol toxicity to microbes. Modern omics approaches have made significant progress in addressing the issue of low butanol tolerance, but a strain capable of both synthesis and tolerance at commercializable concentrations has yet to be discovered or produced.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Food Science & Technology
Karolinny Cristiny de Oliveira Vieira, Hevelin Regiane Augusto da Silva, Isabela Poletto Masselli Rocha, Emmanuel Barboza, Lizziane Kretli Winkelstroter Eller
Summary: Outbreaks and deaths related to Foodborne Diseases (FBD) are constantly occurring worldwide, largely due to consumption of contaminated foodstuffs with pathogens. This review discusses the main omic techniques applied in foodborne pathogens and their potential in ensuring food safety. Omics have been shown to integrate variables that contribute to food safety and improve consumer health, costs, and product quality.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Agricultural Engineering
Lamei Zheng, Wuyun Wu, Qingyu Chen, Genfa Zhang, Fei Gao, Yijun Zhou
Summary: This study investigated the metabolic pathways and molecular mechanisms associated with heat stress response in jojoba leaves using a combination of physiological and multi-omics techniques. The results showed that protein folding and sorting, photosynthesis, signal pathways, ROS scavenging, energy metabolism, and carbohydrate metabolism were closely related to the heat stress response of jojoba. Metabolomics analysis identified significant changes in the content of certain metabolites under heat stress. Multi-omics analysis revealed the important roles of soluble sugars and amino acids in maintaining osmotic balance and alleviating heat stress-induced damage.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Nutrition & Dietetics
Lynnette Ferguson, Matthew Barnett
Summary: Nutrigenomics New Zealand (NuNZ) was a collaborative research programme established by three organizations with the aim of studying the application of nutrigenomics in New Zealand and exploring its potential benefits in the plant food and agricultural sectors. The programme divided nutrigenomics into personalized nutrition and nutrigenomics, utilizing various science laboratories for comprehensive analysis to understand the impact of food products and diets on health.
Review
Cell Biology
Jia-Chen Liu, Shan-Shan Dong, Hui Shen, Dan-Yue Yang, Bin-Bin Chen, Xue-Ying Ma, Yi-Ran Peng, Hong-Mei Xiao, Hong-Wen Deng
Summary: Sarcopenia is a systemic disease characterized by muscle dysfunction, with its genetic architecture and molecular mechanisms still largely unclear. Recent advancements in multi-omics studies offer new insights into the pathogenesis of sarcopenia and may lead to new clinical applications.
AGEING RESEARCH REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Mengyuan Kan, Blanca E. Himes
Summary: Glucocorticoid drugs are widely used in the treatment of diseases, but there is still much to learn about their cell type-specific mechanisms and why patients respond differently. Recent studies have used genomics, transcriptomics, and other omics approaches to address these questions, but there are still knowledge gaps to be filled related to glucocorticoid action mechanisms.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Plant Sciences
Yamshi Arif, Priyanka Singh, Andrzej Bajguz, Pravej Alam, Shamsul Hayat
Summary: This review discusses the crucial role of silicon in plant development and stress responses, highlighting its interactions with plant hormones and antioxidants, as well as its application in 'omic approaches. Furthermore, it emphasizes the need for further research on the role of silicon during abiotic stress in plants for a better understanding at a broader level.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Pengyu Liu, Wenxuan Wang, Fei Wang, Jiaqi Fan, Jinan Guo, Tao Wu, Dongliang Lu, Qingchun Zhou, Zhuohao Liu, Yuliang Wang, Zhiqun Shang, Franky Leung Chan, Wei Yang, Xin Li, Shan-Chao Zhao, Qingyou Zheng, Dinglan Wu
Summary: In this study, proteomic and metabolomic analysis of exosomes from prostate cancer (PCa) patients was performed. Several potential biomarkers for PCa and castration resistant prostate cancer (CRPC) were identified, including the proteins LRG1 and ITIH3. Metabolomic evaluation also revealed differentially expressed metabolites. These findings suggest the potential of exosomal proteins and metabolites as markers for CRPC and confirm the important role of the protein LRG1 in PCa progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins
Summary: The goal of this study was to develop an atlas of the metabolic, transcriptional, and proteomic changes in the maternal heart during and after pregnancy. The results showed significant increases in heart size, cardiac hypertrophy, and myocyte cross-sectional area during pregnancy and post-birth, accompanied by changes in metabolites, gene expression, and protein levels. These findings provide important insights into the coordinated molecular changes that occur in the maternal heart during and after pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ranjna Sirohi, Jaemin Joun, Hong Ii Choi, Vivek Kumar Gaur, Sang Jun Sim
Summary: This article discusses the potential of microalgae as an energy feedstock and the efforts to increase microalgae productivity using various omics techniques, with a particular focus on the application of genome sequencing and metabolic engineering in this field.
MICROBIAL CELL FACTORIES
(2021)
Review
Fisheries
Thao V. Nguyen, Andrea C. Alfaro, Craig Mundy, Jillian Petersen, Norman L. C. Ragg
Summary: The steady increase in global abalone aquaculture production has led to growing interest in applying new technologies, such as omics approaches, for abalone research. Omics techniques like genomics, transcriptomics, proteomics, and metabolomics are revealing key molecules and pathways in biological processes and identifying potential biomarkers. Integration of multiple omics approaches shows great potential in overcoming challenges and limitations to improve abalone production.
Article
Cell Biology
Kangxin Li, Guiming Chen, Haihua Luo, Jianhang Li, Aihua Liu, Chen Yang, Juan Wang, Jia Xu, Shenghan Gao, Peng Chen, Yong Jiang
Summary: Myeloid-related protein 8/14 has been found to inhibit macrophage efferocytosis of apoptotic cells and promote phenotypic polarization of macrophages, potentially offering novel therapeutic strategies for inflammation resolution.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Jieyan Wang, Yingyi Luan, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Jie Fan
Summary: The study identifies an intra-PMN mechanism that negatively regulates necroptosis mediated through TBK1/IKK epsilon, reducing inflammation by suppressing the formation of the necrosome complex. The LPS-TLR4-TBK1 axis serves as a negative regulator for PMN necroptosis, suggesting it may be a therapeutic target for modulating PMN death and inflammation.
Article
Multidisciplinary Sciences
Zhengzheng Yan, Haihua Luo, Bingyao Xie, Tian Tian, Shan Li, Zhixia Chen, Jinghua Liu, Xuwen Zhao, Liyong Zhang, Yongqiang Deng, Timothy R. Billiar, Yong Jiang
Summary: SLP76 plays an important role in RAGE-mediated pro-inflammatory signaling, and targeting its signaling pathway could be a therapeutic approach for sepsis.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Xiaohuan Chen, Yun Liu, Hallie Dolin, Jinghua Liu, Yong Jiang, Zhixing K. Pan
Summary: A high-throughput drug screening platform was established in this study, revealing pinaverium bromide (PVB) as a potential therapeutic agent for sepsis by inhibiting primed neutrophils and improving survival rates in mice challenged with endotoxin. PVB also showed protective effects on organ damage and reduced inflammation in liver and lung.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ting Bei, Xusong Cao, Yun Liu, Jinmei Li, Haihua Luo, Lin Huang, Tian Tian, Lei Li, Yong Jiang
Summary: Total body irradiation during bone marrow transplantation increases reactive oxygen species in the bone marrow microenvironment, reducing engraftment ability of donor cells and impacting recipient bone marrow recovery. Recipients are at high risk of infection in the early post-transplantation weeks. Fusion proteins like CPP-SOD1 may enhance engraftment efficiency and manipulate ROS during BMT.
Article
Pharmacology & Pharmacy
Rui Li, Li Xie, Lei Li, Xiaojiao Chen, Tong Yao, Yuanxin Tian, Qingping Li, Kai Wang, Chenyang Huang, Cui Li, Yifan Li, Hongwei Zhou, Neil Kaplowitz, Yong Jiang, Peng Chen
Summary: Gut microbiota and their metabolites play a crucial role in the development of liver injury. This study investigates the impact of gut microbes on hepatic ischemia/reperfusion injury (HIRI). The results demonstrate that specific microbial metabolites can protect mice against HIRI by suppressing macrophage pro-inflammatory response and reducing the diurnal variation of liver injury.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Immunology
Haihong Fang, Yidong Zhang, Jiancheng Wang, Lulan Li, Sheng An, Qiaobing Huang, Zhongqing Chen, Hong Yang, Jie Wu, Zhenhua Zeng
Summary: The study demonstrated that remimazolam can attenuate inflammatory response in SALI, possibly through the activation of peripheral benzodiazepine receptors and inhibition of p38 phosphorylation in macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Respiratory System
Yingzhi Wang, Liming Lei, Huawei Yang, Songbin He, Junhai Hao, Tao Liu, Xingdong Chen, Yongbo Huang, Jing Zhou, Zhimin Lin, Haichong Zheng, Xiaoling Lin, Weixiang Huang, Xiaoqing Liu, Yimin Li, Linxi Huang, Wenbing Qiu, Huangyao Ru, Danni Wang, Jianfeng Wu, Huifang Zheng, Liuer Zuo, Peiling Zeng, Jian Zhong, Yanhui Rong, Min Fan, Jianwei Li, Shaoqing Cai, Qiuye Kou, Enhe Liu, Zhuandi Lin, Jingjing Cai, Hong Yang, Fen Li, Yanhong Wang, Xinfeng Lin, Weitao Chen, Youshan Gao, Shifang Huang, Ling Sang, Yuanda Xu, Kouxing Zhang
Summary: Mechanical ventilation is crucial in ICU, but prolonged use can lead to complications such as VAP. Timely and safe weaning is important for patients. A multicenter cohort study in China aims to explore variations in weaning practices, associations between initial MV reasons and clinical outcomes, and factors related to weaning strategies.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Surgery
Lin Huang, Jiawei Chen, Xiaojie Li, Mingxin Huang, Jilou Liu, Na Qin, Zhenhua Zeng, Xingmin Wang, Fen Li, Hong Yang
Summary: This study demonstrates that PD alleviates SAE by upregulating Sir1-mediated neuroinflammation inhibition and mitochondrial function protection. The findings suggest that PD has potential therapeutic value in treating SAE.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Microbiology
Zhuoen He, Yunong Zeng, Shuyu Li, Lizhen Lin, Ruisi Zhou, Fangzhao Wang, Wenjiao Yang, Yuhao Wu, Junhao Yang, Ali Chen, Zhang Wang, Hong Yang, Xiaoshan Zhao, Wei Xiao, Lei Li, Shenhai Gong
Summary: This study highlights the significance of gut commensal fungi in hepatic inflammation and oxidative stress in APAP-induced liver injury and suggests a promising therapeutic strategy targeting Cyp2a5 for DILI treatment.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mingxin Huang, Yiqin Yu, Xuheng Tang, Rui Dong, Xiaojie Li, Fen Li, Yongxin Jin, Shenhai Gong, Xingmin Wang, Zhenhua Zeng, Lin Huang, Hong Yang
Summary: This study used the MIMIC-III database to investigate the correlation between ketone body levels and clinical prognosis in septic patients. It was found that exogenous 3-hydroxybutyrate supplementation improved the survival rate of sepsis and protected against sepsis-induced lung damage through promoting autophagy.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shuangbin Xu, Zehan Dai, Pingfan Guo, Xiaocong Fu, Shanshan Liu, Lang Zhou, Wenli Tang, Tingze Feng, Meijun Chen, Li Zhan, Tianzhi Wu, Erqiang Hu, Yong Jiang, Xiaochen Bo, Guangchuang Yu
Summary: ggtreeExtra is a universal tool for visualizing tree data, supporting various data types and visualization methods. By integrating evolutionary statistics and external data, it extends the applications of phylogenetic trees in different disciplines.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Cell Biology
Qizheng Han, Junhao Wang, Haihua Luo, Lei Li, Xinya Lu, Aihua Liu, Yongqiang Deng, Yong Jiang
Summary: This study analyzed the mechanisms associated with SARS-CoV-2 infection through gene expression profiling and network inference, identifying TMBIM6 as a potential therapeutic target. It shed light on the disruption of apoptosis, endoplasmic reticulum stress, and lipid metabolism pathways during SARS-CoV-2 infection, providing insight into novel therapeutic approaches for COVID-19.