The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice

IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages

(2021) Brent A. Stanfield et al.   PLoS One

Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters

(2019) Lulu Sun et al.   Acta Pharmaceutica Sinica B

miRNA-548ah promotes the replication and expression of hepatitis B virus by targeting histone deacetylase 4

(2019) Tongjing Xing et al.   LIFE SCIENCES

Microbiome diurnal rhythmicity and its impact on host physiology and disease risk

(2019) Samuel Philip Nobs et al.   EMBO REPORTS

Antibiotic pretreatment alleviates liver transplant damage in mice and humans

(2019) Kojiro Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Circadian Rhythms Have Effects on Surgical Outcomes of Liver Transplantation for Patients With Hepatocellular Carcinoma: A Retrospective Analysis of 147 Cases in a Single Center

(2019) Sheng-Sheng Ren et al.   TRANSPLANTATION PROCEEDINGS

The influences of cholecystectomy on the circadian rhythms of bile acids as well as the enterohepatic transporters and enzymes systems in mice

(2018) Fan Zhang et al.   CHRONOBIOLOGY INTERNATIONAL

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice

(2018) Shenhai Gong et al.   JOURNAL OF HEPATOLOGY

HDAC inhibition helps post-MI healing by modulating macrophage polarization

(2018) Denise Kimbrough et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

(2018) Jun Wang et al.   Nature Communications

TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia

(2018) Ziping Han et al.   Aging and Disease

The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis

(2018) Gianluigi Mazzoccoli et al.   Frontiers in Physiology

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes

(2018) Dongyin Guan et al.   CELL

Protective role of hepatocyte cyclooxygenase-2 expression against liver ischemia-reperfusion injury in mice

(2018) Omar Motiño et al.   HEPATOLOGY

Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice

(2018) Shenhai Gong et al.   HEPATOLOGY

SIRT3 a Major Player in Attenuation of Hepatic Ischemia-Reperfusion Injury by Reducing ROS via Its Downstream Mediators: SOD2, CYP-D, and HIF-1α

(2018) Gaurav Katwal et al.   Oxidative Medicine and Cellular Longevity

Hepatic Ischemia/Reperfusion: Mechanisms of Tissue Injury, Repair, and Regeneration

(2017) Takanori Konishi et al.   GENE EXPRESSION

Macrophage heme oxygenase-1-SIRT1-p53 axis regulates sterile inflammation in liver ischemia-reperfusion injury

(2017) Kojiro Nakamura et al.   JOURNAL OF HEPATOLOGY

An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

(2017) Xiao-Jing Zhang et al.   NATURE MEDICINE

Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations

(2016) Christoph A. Thaiss et al.   CELL

Sirtuin 1 Stimulation Attenuates Ischemic Liver Injury and Enhances Mitochondrial Recovery and Autophagy

(2016) Adam Khader et al.   CRITICAL CARE MEDICINE

The myeloid heat shock transcription factor 1/β-catenin axis regulates NLR family, pyrin domain-containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury

(2016) Shi Yue et al.   HEPATOLOGY

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury

(2016) Dietrich A. Ruess et al.   PLoS One

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Transcriptional Regulation ofJARID1B/KDM5BHistone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia

(2015) Haijun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury

(2015) Yuanxing Liu et al.   JOURNAL OF HEPATOLOGY

Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury

(2015) Bingfang Hu et al.   JOURNAL OF HEPATOLOGY

Protective Effects of Dihydrocaffeic Acid, a Coffee Component Metabolite, on a Focal Cerebral Ischemia Rat Model

(2015) Kyungjin Lee et al.   MOLECULES

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury

(2014) Haofeng Ji et al.   HEPATOLOGY

Inhibition of Histone Deacetylase by Butyrate Protects Rat Liver from Ischemic Reperfusion Injury

(2014) Jie Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

(2014) Brian P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase CK2 Regulates the Dimerization of Histone Deacetylase 1 (HDAC1) and HDAC2 during Mitosis

(2013) Dilshad H. Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casein Kinase-2α1 Induces Hypertrophic Response by Phosphorylation of Histone Deacetylase 2 S394 and its Activation in the Heart

(2011) Gwang Hyeon Eom et al.   CIRCULATION

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity

(2010) John Evankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration

(2010) Mariëlle Verweij et al.   LIVER TRANSPLANTATION

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

(2010) Eric E Zhang et al.   NATURE MEDICINE

First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption

(2010) René Fumeaux et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells

(2009) María Monagas et al.   BRITISH JOURNAL OF NUTRITION

The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury

(2009) Tessa M. van Ginhoven et al.   LIVER TRANSPLANTATION

Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo

(2008) Y ABE et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2008) Andrew Vardanian et al.   MOLECULAR MEDICINE

Investigation of the metabolic fate of dihydrocaffeic acid

(2007) Laure Poquet et al.   BIOCHEMICAL PHARMACOLOGY