Article
Oncology
Shuyue Zheng, Xin-Yuan Guan
Summary: Ferroptosis is a cell death that occurs due to the accumulation of ferrous ions and lipid peroxidation in tumor cells. Targeting ferroptosis as a novel strategy for anti-tumor therapy involves regulating various metabolic and immune elements. This review highlights the mechanism of ferroptosis, its interaction with cancer and tumor immune microenvironment, particularly the relationship between immune cells and ferroptosis. Additionally, it discusses the latest preclinical progress in combining ferroptosis-targeted drugs with immunotherapy, and the optimal conditions for their combined use, providing insight into the potential value of ferroptosis in cancer immunotherapy.
Review
Oncology
Zhengzhen Xia, Yi Quan
Summary: Ferroptosis is a lipid peroxidation-induced, iron-dependent programmed cell death that is closely associated with tumorigenesis, development, treatment, and tumor immune regulation. This study investigates the connection between ferroptosis and immune regulation, providing a theoretical basis for targeting ferroptosis and tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Shilang Xiao, Xiaoming Liu, Lingzhi Yuan, Xiao Chen, Fen Wang
Summary: This study revealed that by varying the activation degrees of ferroptosis, tumor cells and their surrounding microenvironment could be shaped. Establishing ferroptosis-related subtypes would guide in predicting the biological features of individual tumors and selecting appropriate treatment protocols for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yuancheng Huang, Zehong Yang, Chaoyuan Huang, Xiaotao Jiang, Yanhua Yan, Kunhai Zhuang, Yi Wen, Fengbin Liu, Peiwu Li
Summary: The study investigated the role of m(6)A-related lncRNAs in gastric adenocarcinoma and their prognostic value. Through analysis of gene expression and clinicopathological data, different patient clusters were identified based on m(6)A-related lncRNAs, and a prognostic signature was established. The prognostic signature showed significant predictive value for overall survival, clinicopathological characteristics, tumor microenvironment, and immune response in patients with gastric adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Xu, Na Zhou, Hongwei Lan, Fangfang Yang, Bowen Dong, Xiaochun Zhang
Summary: Ferroptosis, a form of programmed cell death, plays an integral role in regulating the tumor immune microenvironment and can enhance the efficacy of tumor immunotherapy. This study identified three molecular subtypes of ferroptosis in gastric cancer and examined their association with the characteristics of the tumor microenvironment. A ferroptosis score was constructed to predict immunotherapy response and prognosis. The findings suggest that ferroptosis plays an important role in gastric cancer and the ferroptosis score can serve as an independent prognostic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xue Liu, Chenyang Xu, Tianwei Guo, Shenghua Zhan, Qiuying Quan, Mengsi Li, Ziyi Wang, Xueguang Zhang, Lingchuan Guo, Lei Cao
Summary: CD155 expression is positively correlated with tumor microenvironment cell infiltration and gastric adenocarcinoma progression. It is associated with aggressive clinicopathological features and immune-related factors. CD155 may play a pivotal role in gastric adenocarcinoma development and become a novel target for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Weiju Zhang, Sumei Yao, Hua Huang, Hao Zhou, Haomiao Zhou, Qishuang Wei, Tingting Bian, Hui Sun, Xiaoli Li, Jianguo Zhang, Yifei Liu
Summary: Recent studies have identified three different molecular subtypes in lung adenocarcinoma (LUAD) mediated by ferroptosis-related genes, each with different prognoses. Analysis of tumor microenvironment (TME) cell infiltration revealed immune heterogeneity among these subtypes. The ferroptosis score can predict tumor subtype, immunity, and prognosis, and is associated with response to anti-PD-1/L1 immunotherapy in LUAD patients.
Article
Oncology
Biao Deng, Jing Xiang, Zhu Liang, Lianxiang Luo
Summary: This study reveals the involvement of ferroptosis in regulating immune cell infiltration and immunotherapeutic efficacy in LUAD. A seven-gene risk signature is established as an independent prognostic factor for LUAD. High-risk and low-risk groups show significant differences in immunocyte infiltration levels, immune checkpoints, and immunotherapy response rates.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Yefeng Shen, Deyu Li, Qiong Liang, Mengsi Yang, Youguang Pan, Hui Li
Summary: This study investigated the genomic alterations in lung adenocarcinoma samples and identified three distinct gene subsets. They also developed a CuFescore scoring scheme to predict patient sensitivity to immunotherapy and chemotherapeutic drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Jiazheng Li, Renshen Xiang, Wei Song, Jing Wu, Can Kong, Tao Fu
Summary: In this study, a novel prognostic model based on 10 ferroptosis-related lncRNA pairs was established. High-risk patients exhibited characteristics of high immune cell infiltration, upregulated carcinogenic and stromal activities, and heightened sensitivity to anti-tumor drugs. Low-risk patients showed better responses to methotrexate treatment and increased sensitivity to immunotherapy.
FRONTIERS IN GENETICS
(2022)
Review
Pharmacology & Pharmacy
Ling Lu, Bei Chen, Yumeng Xu, Xinyi Zhang, Longtao Jin, Hui Qian, Yi Wang, Zhao Feng Liang
Summary: This article summarizes the roles and functions of ferroptosis and ferroptosis-related ncRNAs in the tumorigenesis, development, and prognosis of gastric cancer (GC) and prospects the future research direction and challenges.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Robin Demuynck, Iuliia Efimova, Faye Naessens, Dmitri Krysko
Summary: Ferroptosis is a newly discovered form of regulated cell death distinct from apoptosis and necroptosis, and has potential in anticancer therapy. However, ferroptotic cancer cells may pose a risk of tumor evasion due to decreased phagocytosis and antigen cross-presentation. Factors such as lactate, acidification, and hypoxia in the tumor microenvironment play a role in promoting ferroptosis resistance and affecting its immunogenicity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Environmental Sciences
Zhiya Zhang, Yin Liao, Peiyou Zhao, Xinwei Chen, Yunfei Liu, Ji Wu, Hongbin Zuo
Summary: The Hypoxia-score is proven to be a valuable tool for assessing the prognosis of gastric cancer patients and guiding drug treatments, providing significant guidance for clinical diagnosis and treatment in the context of gastric cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaohu Ouyang, Rui Zhu, Lan Lin, Xunxun Wang, Qigang Zhuang, Desheng Hu
Summary: This study identified ferroptosis-related genes in lung adenocarcinoma and developed a predictive model for prognosis and treatment outcomes. It also discovered a potential therapeutic approach of using immunotherapy and targeting GAPDH to induce ferroptosis in lung adenocarcinoma.
Article
Multidisciplinary Sciences
Chongkai Fang, Silin Liu, Kunliang Feng, Chaoyuan Huang, Ying Zhang, Jinan Wang, Hongtong Lin, Junyan Wang, Chong Zhong
Summary: This study aimed to construct a ferroptosis-related lncRNA signature to predict the prognosis and immune infiltration of HCC patients. The findings suggest that this signature has promising clinical prediction value and potential implications for immunotherapy in patients with HCC.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Lianxiang Luo, Manshan Li, Jiating Su, Xinyue Yao, Hui Luo
Summary: FURIN is highly expressed in lung adenocarcinoma and significantly associated with poor overall survival, as well as correlated with immune cells and macrophage immune marker in LUAD patients. This suggests that FURIN could serve as a potential biomarker for prognosis and immune infiltration in LUAD patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lianxiang Luo, Xinyue Yao, Jing Xiang, Fangfang Huang, Hui Luo
Summary: This study analyzed datasets from HCC patients and identified a four-gene signature that can predict HCC prognosis. It also highlighted the potential role of PRDX1, a ferroptosis-related gene, in HCC and its potential as a biomarker for predicting HCC outcome.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Lianxiang Luo, Xinyue Yao, Jing Xiang
Summary: This study constructed a model based on pyroptosis-related genes (PRGs) to predict the prognosis of non-small-cell lung cancer (NSCLC). The core gene BNIP3 was identified as a diagnostic biomarker for NSCLC.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Oncology
Lianxiang Luo, Xinming Chen
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Biochemistry & Molecular Biology
Lianxiang Luo, Xinming Chen, Fangfang Huang
Summary: In this study, machine learning methods were used to determine the regulators of ferroptosis in lung adenocarcinoma. The researchers developed a deep learning neural network model to predict ferroptosis and identified RRM2 and AURKA as key suppressors of ferroptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Virology
Xinyue Yao, Wanwan Dai, Siyu Yang, Zhaoli Wang, Qian Zhang, Qinghui Meng, Tao Zhang
Summary: Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) can infect porcine pulmonary microvascular endothelial cells (MVECs) and damage the endothelial glycocalyx. This study further explored the synergistic effect of HP-PRRSV and lipopolysaccharide (LPS) on the inflammatory response of MVECs. The results provide insights into the mechanism of severe lung injury caused by secondary bacterial infection following HP-PRRSV infection.