The Nerve Growth Factor Metabolic Pathway Dysregulation as Cause of Alzheimer’s Cholinergic Atrophy

Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance

(2021) Changiz Geula et al.   JOURNAL OF NEUROCHEMISTRY

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2020) Juan Fortea et al.   LANCET

The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease

(2020) Rowan Pentz et al.   MOLECULAR PSYCHIATRY

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

(2020) Gabriella Marucci et al.   NEUROPHARMACOLOGY

Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation

(2020) Rashmi Gamage et al.   Frontiers in Cellular Neuroscience

Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study

(2020) Rowan Pentz et al.   Alzheimers & Dementia

A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer's pathology

(2020) Rowan Pentz et al.   NEUROBIOLOGY OF DISEASE

Identification and Preliminary Validation of a Plasma Profile Associated with Cognitive Decline in Dementia and At-Risk Individuals: A Retrospective Cohort Analysis

(2019) M. Florencia Iulita et al.   JOURNAL OF ALZHEIMERS DISEASE

The Brain NGF Metabolic Pathway in Health and in Alzheimer’s Pathology

(2019) A. Claudio Cuello et al.   Frontiers in Neuroscience

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

(2019) Sumonto Mitra et al.   Frontiers in Neuroscience

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation

(2019) Kurt R. Lehner et al.   Frontiers in Immunology

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition

(2019) Michael Vacher et al.   Scientific Reports

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons

(2018) Simon Allard et al.   NEUROBIOLOGY OF AGING

Longitudinal Alzheimer’s Degeneration Reflects the Spatial Topography of Cholinergic Basal Forebrain Projections

(2018) Taylor W. Schmitz et al.   Cell Reports

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

Analysis of Matrix Metallo-Proteases and the Plasminogen System in Mild Cognitive Impairment and Alzheimer's Disease Cerebrospinal Fluid

(2018) Cecilia E. Hanzel et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2018) Juan Fortea et al.   LANCET NEUROLOGY

Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome

(2017) Filippo Caraci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Stop Alzheimer’s before it starts

(2017) Eric McDade et al.   NATURE

Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease

(2017) M. Florencia Iulita et al.   NEUROBIOLOGY OF DISEASE

Early and Late CNS Inflammation in Alzheimer’s Disease: Two Extremes of a Continuum?

(2017) A. Claudio Cuello   TRENDS IN PHARMACOLOGICAL SCIENCES

On the path to 2025: understanding the Alzheimer’s disease continuum

(2017) Paul S. Aisen et al.   Alzheimers Research & Therapy

An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation

(2016) M. Florencia Iulita et al.   Alzheimers & Dementia

A Link Between Nerve Growth Factor Metabolic Deregulation and Amyloid-β-Driven Inflammation in Down Syndrome

(2016) Maria Florencia Iulita et al.   CNS & Neurological Disorders-Drug Targets

Cerebrospinal Fluid proNGF: A Putative Biomarker for Early Alzheimer's Disease

(2016) Scott E. Counts et al.   Current Alzheimer Research

Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years

(2016) Patrick L. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

(2016) Taylor W. Schmitz et al.   Nature Communications

The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease

(2015) M. Florencia Iulita et al.   Current Alzheimer Research

Matrix metalloproteinases in inflammation

(2014) Liisa Nissinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nerve growth factor metabolic dysfunction in Down’s syndrome brains

(2014) M. Florencia Iulita et al.   BRAIN

The Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials

(2014) Reisa Sperling et al.   NEURON

Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

(2014) M. Florencia Iulita et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging

(2012) Vinay Parikh et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Impact of the NGF Maturation and Degradation Pathway on the Cortical Cholinergic System Phenotype

(2012) S. Allard et al.   JOURNAL OF NEUROSCIENCE

Prior Pathology in the Basal Forebrain Cholinergic System Predisposes to Inflammation-Induced Working Memory Deficits: Reconciling Inflammatory and Cholinergic Hypotheses of Delirium

(2012) R. H. Field et al.   JOURNAL OF NEUROSCIENCE

Preplaque (‘Preclinical’) Aß-Induced Inflammation and Nerve Growth Factor Deregulation in Transgenic Models of Alzheimer’s Disease-Like Amyloid Pathology

(2012) A.C. Cuello et al.   Neurodegenerative Diseases

Perspective: Prevention is better than cure

(2011) Sam Gandy   NATURE

NGF and proNGF Regulate Functionally Distinct mRNAs in PC12 Cells: An Early Gene Expression Profiling

(2011) Mara D'Onofrio et al.   PLoS One

Cholinergic Involvement in Alzheimer’s Disease. A Link with NGF Maturation and Degradation

(2009) A. Claudio Cuello et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

(2009) Jennifer H. K. Choi et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid β-Induced Nerve Growth Factor Dysmetabolism in Alzheimer Disease

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Increased Matrix Metalloproteinase 9 Activity in Mild Cognitive Impairment

(2009) Martin A. Bruno et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease

(2008) Andrew M. Hall et al.   Alzheimers & Dementia

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

(2008) Raya Al-Shawi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Temporal and functional dynamics of the transcriptome during nerve growth factor-induced differentiation

(2008) Thomas F. Dijkmans et al.   JOURNAL OF NEUROCHEMISTRY