Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina

Oxysterols and retinal degeneration

(2021) Xun Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of a TSPO ligand on retinal pigment epithelial cholesterol homeostasis in high-fat fed mice, implication for age-related macular degeneration

(2021) Lincoln Biswas et al.   EXPERIMENTAL EYE RESEARCH

Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update

(2020) Jasmina Dimitrova-Shumkovska et al.   Cells

Microglia modulation by TGF-β1 protects cones in mouse models of retinal degeneration

(2020) Sean K. Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Etifoxine reverses weight gain and alters the colonic bacterial community in a mouse model of obesity

(2020) Khalid S. Ibrahim et al.   BIOCHEMICAL PHARMACOLOGY

Raloxifene as Treatment for Various Types of Brain Injuries and Neurodegenerative Diseases: A Good Start

(2020) Leo Veenman   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice

(2019) Michael Landowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice

(2019) Xun Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cellular Sources and Regional Variations in the Expression of the Neuroinflammatory Marker Translocator Protein (TSPO) in the Normal Brain

(2018) Calina Betlazar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TSPO Ligands Promote Cholesterol Efflux and Suppress Oxidative Stress and Inflammation in Choroidal Endothelial Cells

(2018) Lincoln Biswas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration

(2017) Lincoln Biswas et al.   HUMAN MOLECULAR GENETICS

The genetics of age-related macular degeneration (AMD) – Novel targets for designing treatment options?

(2015) Felix Grassmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration

(2015) Rebecca Scholz et al.   Journal of Neuroinflammation

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

(2015) Jinjiang Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of age-related macular degeneration-like pathology by complement factor H

(2015) Christopher B. Toomey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal microglia: Just bystander or target for therapy?

(2015) Marcus Karlstetter et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis

(2014) Lan N. Tu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis

(2014) Marcus Karlstetter et al.   Journal of Neuroinflammation

Cholesterol in the retina: The best is yet to come

(2014) Irina A. Pikuleva et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand

(2014)  ukasz Jaremko et al.   SCIENCE

Drug Ligand-Induced Activation of Translocator Protein (TSPO) Stimulates Steroid Production by Aged Brown Norway Rat Leydig Cells

(2013) J.-Y. Chung et al.   ENDOCRINOLOGY

Translocator Protein/Peripheral Benzodiazepine Receptor Is Not Required for Steroid Hormone Biosynthesis

(2013) Kanako Morohaku et al.   ENDOCRINOLOGY

Prevalence of age-related macular degeneration in persons aged 90 years and older in Cologne

(2012) Manuel Hermann et al.   ACTA OPHTHALMOLOGICA

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Prevalence of Age-related Macular Degeneration in Old Persons: Age, Gene/Environment Susceptibility Reykjavik Study

(2010) Fridbert Jonasson et al.   OPHTHALMOLOGY

Abundant Lipid and Protein Components of Drusen

(2010) Lan Wang et al.   PLoS One

Esterified Cholesterol Is Highly Localized to Bruch's Membrane, as Revealed by Lipid Histochemistry in Wholemounts of Human Choroid

(2009) Martin Rudolf et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

Lipoic acid prevents high-fat diet–induced dyslipidemia and oxidative stress: A microarray analysis

(2008) Rui-li Yang et al.   NUTRITION