Remodeling the ECM: Implications for Metastasis and Tumor Dormancy

Circadian control of the secretory pathway maintains collagen homeostasis

(2020) Joan Chang et al.   NATURE CELL BIOLOGY

Tumor cell–organized fibronectin maintenance of a dormant breast cancer population

(2020) Lauren E. Barney et al.   Science Advances

Role of Collagen Fiber Morphology on Ovarian Cancer Cell Migration Using Image-Based Models of the Extracellular Matrix

(2020) Samuel Alkmin et al.   Cancers

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

(2019) Patrick Carlson et al.   NATURE CELL BIOLOGY

EMT is associated with an epigenetic signature of ECM remodeling genes

(2019) Paul Peixoto et al.   Cell Death & Disease

Genetic Disorders of the Extracellular Matrix

(2019) Shireen R. Lamandé et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Ageing significantly impacts the biomechanical function and structural composition of skin

(2019) Abigail K. Langton et al.   EXPERIMENTAL DERMATOLOGY

Development of nanotechnology for advancement and application in wound healing: A review

(2019) Debalina Bhattacharya et al.   IET Nanobiotechnology

Tenascin-C increases lung metastasis by impacting blood vessel invasions

(2019) Zhen Sun et al.   MATRIX BIOLOGY

Syndecan-mediated ligation of ECM proteins triggers proliferative arrest of disseminated tumor cells

(2019) Tsukasa Shibue et al.   CANCER RESEARCH

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration

(2019) Maïlys Le Borgne-Rochet et al.   JOURNAL OF CELL SCIENCE

MatrisomeDB: the ECM-protein knowledge database

(2019) Xinhao Shao et al.   NUCLEIC ACIDS RESEARCH

Transmission of breast cancer by a single multiorgan donor to 4 transplant recipients

(2018) Yvette A. H. Matser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chemotherapeutic drug delivery by tumoral extracellular matrix targeting

(2018) René Raavé et al.   JOURNAL OF CONTROLLED RELEASE

Collagen-silica bio-composite enriched with Cynodon dactylon extract for tissue repair and regeneration

(2018) Ramesh Kannan Perumal et al.   Materials Science & Engineering C-Materials for Biological Applications

Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells

(2018) Siriporn Keeratichamroen et al.   ONCOLOGY REPORTS

Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche

(2018) Meryem B. Baghdadi et al.   NATURE

Dormant tumour cells, their niches and the influence of immunity

(2018) Erica T. Goddard et al.   NATURE CELL BIOLOGY

Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer

(2018) Joanne Marie O’Rourke et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis

(2018) Brett L. Ecker et al.   Cancer Discovery

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone

(2016) Trevor T. Price et al.   Science Translational Medicine

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

(2016) Satish Khurana et al.   Nature Communications

Dormant tumor cells expressing LOXL2 acquire a stem-like phenotype mediating their transition to proliferative growth

(2016) Keren Weidenfeld et al.   Oncotarget

Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells

(2016) Brett A. Morris et al.   EBioMedicine

Integrin-linked kinase regulates the niche of quiescent epidermal stem cells

(2015) Jessica Morgner et al.   Nature Communications

NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes

(2015) Maria Soledad Sosa et al.   Nature Communications

Tenascin C in metastasis: A view from the invasive front

(2015) Camille M Lowy et al.   Cell Adhesion & Migration

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

(2015) Christine Mehner et al.   Oncotarget

Sol–Gel Assisted Fabrication of Collagen Hydrolysate Composite Scaffold: A Novel Therapeutic Alternative to the Traditional Collagen Scaffold

(2014) Satiesh Kumar Ramadass et al.   ACS Applied Materials & Interfaces

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors

(2014) Ge Zhang et al.   BMC CANCER

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters

(2014) Alexandra Naba et al.   eLife

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling

(2013) Paloma Bragado et al.   NATURE CELL BIOLOGY

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

Collagen VI regulates satellite cell self-renewal and muscle regeneration

(2013) Anna Urciuolo et al.   Nature Communications

Periostin: A Bridge between Cancer Stem Cells and Their Metastatic Niche

(2012) Zhe Wang et al.   Cell Stem Cell

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

An Update on Donor-Derived Disease Transmission in Organ Transplantation

(2011) M. G. Ison et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

(2011) Yusuke Shiozawa et al.   JOURNAL OF CLINICAL INVESTIGATION

The Matrisome:In SilicoDefinition andIn VivoCharacterization by Proteomics of Normal and Tumor Extracellular Matrices

(2011) Alexandra Naba et al.   MOLECULAR & CELLULAR PROTEOMICS

Physiological type I collagen organization induces the formation of a novel class of linear invadosomes

(2011) Amélie Juin et al.   MOLECULAR BIOLOGY OF THE CELL

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

(2011) Thordur Oskarsson et al.   NATURE MEDICINE

Metastatic Outgrowth Encompasses COL-I, FN1, and POSTN Up-Regulation and Assembly to Fibrillar Networks Regulating Cell Adhesion, Migration, and Growth

(2010) Johanna Soikkeli et al.   AMERICAN JOURNAL OF PATHOLOGY

Metastatic Growth from Dormant Cells Induced by a Col-I-Enriched Fibrotic Environment

(2010) D. Barkan et al.   CANCER RESEARCH

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Balancing dormant and self-renewing hematopoietic stem cells

(2009) Anne Wilson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Long-term Outcomes and Prognostic Factors of Elderly Patients with Hepatocellular Carcinoma Undergoing Hepatectomy

(2009) Jun Huang et al.   JOURNAL OF GASTROINTESTINAL SURGERY