The P2Y12 Receptor Antagonist Selatogrel Dissolves Preformed Platelet Thrombi In Vivo

The potency of selatogrel, a reversible antagonist of the P2Y12 receptor, is affected by calcium concentration

(2021) Martine Baumann et al.   PLATELETS

Selatogrel, a reversible P2Y12 receptor antagonist, has reduced off-target interference with haemostatic factors in a mouse thrombosis model

(2021) Lydie Crescence et al.   THROMBOSIS RESEARCH

Novel approaches to P2Y12 inhibition and aspirin dosing

(2020) William A. E. Parker et al.   PLATELETS

Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes

(2019) Robert F Storey et al.   EUROPEAN HEART JOURNAL

Do we need a new P2Y12 receptor antagonist?

(2019) Jean-Sébastien Hulot et al.   EUROPEAN HEART JOURNAL

Deciphering biased inverse agonism of cangrelor and ticagrelor at P2Y12 receptor

(2018) Cédric Garcia et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines: An Update of the 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention, 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery, 2012 ACC/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease, 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction, 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes, and 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery

(2016) Glenn N. Levine et al.   CIRCULATION

Management of Patients With NSTE-ACS

(2016) Fatima Rodriguez et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updates and Current Recommendations for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes: What It Means for Clinical Practice

(2015) Guillaume Cayla et al.   AMERICAN JOURNAL OF CARDIOLOGY

The origin and concentration of circulating microparticles differ according to cancer type and evolution: A prospective single-center study

(2015) Diane Mege et al.   INTERNATIONAL JOURNAL OF CANCER

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel

(2015) Eva Caroff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spatiotemporal regulation of coagulation and platelet activation during the hemostatic responsein vivo

(2015) L. Ivanciu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

Signaling via P2Y12 May Be Critical for Early Stabilization of Platelet Aggregates

(2014) Henry E. Speich et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

(2013) T. J. Stalker et al.   BLOOD

The Interaction of Integrin αIIbβ3with Fibrin Occurs through Multiple Binding Sites in the αIIbβ-Propeller Domain

(2013) Nataly P. Podolnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Ca2+ modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation

(2011) Sarah Jones et al.   BRITISH JOURNAL OF HAEMATOLOGY

Thienopyridines, but Not Elinogrel, Result in Off-Target Effects at the Vessel Wall That Contribute to Bleeding

(2011) P. Andre et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Historical perspective and future directions in platelet research

(2011) B. S. COLLER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Arterial thrombosis—insidious, unpredictable and deadly

(2011) Shaun P Jackson   NATURE MEDICINE

Platelet signalling networks: Pathway perturbation demonstrates differential sensitivity of ADP secretion and fibrinogen binding

(2011) Federica Lombardi et al.   PLATELETS

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparison between hirudin and citrate in monitoring the inhibitory effects of P2Y12 receptor antagonists with different platelet function tests

(2009) C. A. C. M. PITTENS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS