Pharmacodynamics, pharmacokinetics, and safety of single-dose subcutaneous administration of selatogrel, a novel P2Y12 receptor antagonist, in patients with chronic coronary syndromes

Platelet Inhibition with Cangrelor and Crushed Ticagrelor in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Results of the CANTIC Study

(2019) Francesco Franchi et al.   CIRCULATION

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes

(2019) Juhani Knuuti et al.   EUROPEAN HEART JOURNAL

Clinical Pharmacology of the Reversible and Potent P2Y12 Receptor Antagonist ACT-246475 After Single Subcutaneous Administration in Healthy Male Subjects

(2018) Pierre-Eric Juif et al.   JOURNAL OF CLINICAL PHARMACOLOGY

2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

(2017) Marco Valgimigli et al.   EUROPEAN HEART JOURNAL

Characteristics of dyspnoea and associated clinical outcomes in the CHAMPION PHOENIX study

(2017) William Parker et al.   THROMBOSIS AND HAEMOSTASIS

Long-term antiplatelet therapy following myocardial infarction: implications of PEGASUS-TIMI 54

(2016) William A E Parker et al.   HEART

Randomized Comparison of Different Thienopyridine Loading Strategies in Patients Undergoing Elective Coronary Intervention

(2016) Willibald Hochholzer et al.   JACC-Cardiovascular Interventions

Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention

(2016) Fabiana Rollini et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

P2Y12 receptor inhibition and effect of morphine in patients undergoing primary PCI for ST-segment elevation myocardial infarction

(2016) Johanne Silvain et al.   THROMBOSIS AND HAEMOSTASIS

Morphine delays the onset of action of prasugrel in patients with prior history of ST-elevation myocardial infarction

(2016) Mark Thomas et al.   THROMBOSIS AND HAEMOSTASIS

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

(2015) Marco Roffi et al.   EUROPEAN HEART JOURNAL

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel

(2015) Eva Caroff et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New Reversible and Potent P2Y12 Receptor Antagonist (ACT-246475): Tolerability, Pharmacokinetics, and Pharmacodynamics in a First-in-Man Trial

(2014) Daniela Baldoni et al.   CLINICAL DRUG INVESTIGATION

Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients

(2013) Guido Parodi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hirudin anticoagulation allows more rapid determination of P2Y12 inhibition by the VerifyNow P2Y12 assay

(2013) Rebecca Daly et al.   THROMBOSIS AND HAEMOSTASIS

A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y 12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention

(2012) Robert C. Welsh et al.   Circulation-Cardiovascular Interventions

Randomized Assessment of Ticagrelor Versus Prasugrel Antiplatelet Effects in Patients with ST-Segment–Elevation Myocardial Infarction

(2012) Dimitrios Alexopoulos et al.   Circulation-Cardiovascular Interventions

Prasugrel Versus Tirofiban Bolus With or Without Short Post-Bolus Infusion With or Without Concomitant Prasugrel Administration in Patients With Myocardial Infarction Undergoing Coronary Stenting

(2012) Marco Valgimigli et al.   JACC-Cardiovascular Interventions

Clopidogrel pretreatment of patients with ST-elevation myocardial infarction does not affect platelet reactivity after subsequent prasugrel-loading: Platelet reactivity in an observational study

(2012) Thomas G. Nührenberg et al.   PLATELETS

Why does ticagrelor induce dyspnea?

(2012) Elena Faioni et al.   THROMBOSIS AND HAEMOSTASIS

Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes

(2011) Robert F. Storey et al.   EUROPEAN HEART JOURNAL

Incidence of Dyspnea and Assessment of Cardiac and Pulmonary Function in Patients With Stable Coronary Artery Disease Receiving Ticagrelor, Clopidogrel, or Placebo in the ONSET/OFFSET Study

(2010) Robert F. Storey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes

(2010) Robert F. Storey et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

(2009) Paul A. Gurbel et al.   CIRCULATION