Review
Cardiac & Cardiovascular Systems
Yao Du, Hui Zhang, Xiaoyan Nie, Yajun Qi, Shi Shi, Yingying Han, Wenchen Zhou, Chaoyong He, Lintao Wang
Summary: Sterile inflammation is associated with cardiovascular diseases, and studying the role of inflammation caused by the cGAS-STING pathway provides potential therapeutic targets for cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Qiang Guo, Ximiao Chen, Jiaoxiang Chen, Gang Zheng, Chenglong Xie, Hongqiang Wu, Zhimin Miao, Yan Lin, Xiangyang Wang, Weiyang Gao, Xiangtao Zheng, Zongyou Pan, Yifei Zhou, Yaosen Wu, Xiaolei Zhang
Summary: The study investigated the role of STING in osteoarthritis progression, revealing its involvement in ECM metabolism, apoptosis, and senescence in chondrocytes. STING activation of NF-kappa B signaling cascade was found to contribute to OA development, with suppression of STING showing potential as a therapeutic approach.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Ya Liu, Feifei Pu
Summary: This article reviews the important roles of the cGAS-STING signaling pathway in natural immunity, as well as the activation process and therapeutic drugs associated with autoimmune diseases. Studying these signaling pathways is of great significance for improving the diagnosis and treatment of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Lavinia Rech, Peter P. Rainer
Summary: Recent studies have shown that the cGAS-STING pathway is involved in cardiovascular diseases, particularly in response to pathogens. Additionally, self-DNA released during conditions like obesity or myocardial infarction may also activate this pathway. Further research is needed to better understand the interaction of cGAS-STING with cardiovascular risk factors and disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Geriatrics & Gerontology
Weitao Zheng, Dechao Feng, Xingyu Xiong, Xinyang Liao, Sheng Wang, Hang Xu, Weizhen Le, Qiang Wei, Lu Yang
Summary: With aging, the incidence of age-related diseases increases, making them inevitable. The mechanisms behind how aging contributes to the onset and progression of these diseases are still unclear. Inflammation has been found to be closely linked to age-related diseases, and the cGAS-STING signaling pathway plays a crucial role in sensing cytosolic DNA and inducing an inflammatory response. Understanding the structure and molecular biology of this pathway has led to the development of selective inhibitors and agonists for targeting age-related diseases, providing alternative therapeutic options.
Review
Geriatrics & Gerontology
Weitao Zheng, Dechao Feng, Xingyu Xiong, Xinyang Liao, Sheng Wang, Hang Xu, Weizhen Le, Qiang Wei, Lu Yang
Summary: The incidence of age-related diseases increases with aging. Inflammation is closely associated with these diseases and the cGAS-STING signaling pathway plays an important role in the inflammatory response. Selective inhibitors and agonists targeting this pathway have been developed for potential therapeutic alternatives for age-related diseases.
Article
Cell Biology
Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen, Lu Zhang
Summary: This study identified the role of mtDNA as an inflammatory driver in odontoblasts, which defended against bacterial invasion through the cGAS-STING pathway. The findings suggest that targeting the mtDNA-cGAS-STING axis could be a potential therapeutic strategy for preventing severe bacterial inflammation in pulpitis.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biotechnology & Applied Microbiology
Zi-Jie Long, Jun-Dan Wang, Jue-Qiong Xu, Xin-Xing Lei, Quentin Liu
Summary: The accurate duplication and transfer of genetic material is crucial for cell division. The interaction between cell cycle regulation and cGAS/STING signaling plays a significant role in cancer initiation, development, and treatment.
Article
Immunology
Ying Hu, Bangjie Chen, Fan Yang, Yue Su, Dashuai Yang, Yan Yao, Shuxian Wang, Yincui Wu, Liangsong Tao, Tao Xu
Summary: The cGAS-STING signaling pathway plays a vital role in autoimmune diseases, and inhibition of this pathway can alleviate joint swelling and inflammatory cell infiltration.
AUTOIMMUNITY REVIEWS
(2022)
Review
Cell Biology
Yuting Yang, Yiming Huang, Zhenguo Zeng
Summary: Pathogens can produce conserved pathogen-associated molecular patterns (PAMPs) that are recognized by host pattern recognition receptors (PRRs). Recent studies have shown that cytoplasmic DNA receptors can specifically recognize exogenous DNA and activate interferon 1 (IFN1), which is a significant advancement in various research fields. The cGAS-STING signaling pathway is a critical natural immune pathway in cells and plays a crucial role in pathogen infection, tumors, and various autoimmune diseases in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Yang Du, Zhiqiang Hu, Yien Luo, Helen Y. Wang, Xiao Yu, Rong-Fu Wang
Summary: The DNA-sensing receptor cGAS and its downstream signaling adaptor STING play crucial roles in immune defense against infectious pathogens, and the interplay between the cGAS-STING pathway and pathogens provides insight into the development of pharmacological approaches for treating infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yuchen Yang, Li Wang, Ivonne Peugnet-Gonzalez, Daniela Parada-Venegas, Gerard Dijkstra, Klaas Nico Faber
Summary: The intestinal mucosa serves as a barrier and is involved in nutrient absorption. Genetic susceptibility and environmental factors play a critical role in the development of intestinal diseases. The innate immune system recognizes potential threats through pattern recognition receptors (PRRs), including the cGAS-STING pathway. However, the role of the cGAS-STING pathway in intestinal diseases is still debated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lingpu Zhang, Kun Shang, Xiaomin Li, Meifang Shen, Sheng Lu, Dongsheng Tang, Hongbin Han, Yingjie Yu
Summary: A reduction-sensitive polymer is designed to encapsulate a cationic phenanthriplatin drug into nanoparticles, which can release the drug in cancer cells and induce DNA damage and activate immune responses, improving the efficacy of chemo-immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Yu-Hsuan Chen, Han-Hsiun Chen, Won-Jing Wang, Hsin-Yi Chen, Wei-Syun Huang, Chien-Han Kao, Sin-Rong Lee, Nai Yang Yeat, Ruei-Liang Yan, Shu-Jou Chan, Kuen-Phon Wu, Ruey-Hwa Chen
Summary: Activation of tumor-intrinsic innate immunity is crucial for improving immunotherapy. The deubiquitinating enzyme TRABID is found to play a suppressive role in anti-tumor immunity by regulating mitotic cell division and activating the cGAS/STING pathway. TRABID inhibition induces micronuclei and protects cGAS from autophagy, thus promoting anti-tumor immune responses.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Xutong Zhao, Meng Yu, Yawen Zhao, Yiming Zheng, Lingchao Meng, Kang Du, Zhiying Xie, He Lv, Wei Zhang, Jing Liu, Qingqing Wang, Yun Yuan, Zhaoxia Wang, Jianwen Deng
Summary: The study demonstrated that circulating cell-free mtDNA levels were significantly increased in patients with mitochondrial diseases, indicating an association with activation of the cGAS-STING pathway and inflammation.
JOURNAL OF NEUROLOGY
(2022)
Article
Plant Sciences
Hui Na Cao, Jing Ya Ruan, Yu Han, Wei Zhao, Ying Zhang, Chang Gao, Hong Hua Wu, Lin Ma, Xiu Mei Gao, Yi Zhang, Tao Wang
Summary: The flavonoid glycosides from A. wilsonii seeds exhibit anti-inflammatory effects by inhibiting the release of nitric oxide through multiple signaling pathways.
Article
Biochemical Research Methods
Dongxue Zhao, Meiyu Liu, He Sun, Xiaoyan Xu, Simiao Wang, Hongda Wang, Xue Li, Meiting Jiang, Boxue Chen, Yuying Zhao, Xiumei Gao, Wenzhi Yang
Summary: Addressing chemical complexity is crucial in various research fields. The integration of multidimensional chromatography and mass spectrometry enables comprehensive characterization of herbal metabolites. In this study, a three-dimensional liquid chromatography system combined with quadrupole time-of-flight mass spectrometry was used to fully characterize the metabolome of two Astragalus species. By utilizing an in-house library and reference standards, a total of 513 compounds from the Astragalus species were identified. This approach allows for in-depth characterization of herbal metabolites.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Xiaoyan Qin, Qiu Wei, Ran An, Yun Yang, Mingqi Cai, Xiaoling Han, Haoping Mao, Xiumei Gao
Summary: This study investigates the anti-osteoporotic effects of an ethanol extract of FLL in ovariectomized mice and explores the underlying mechanism. The results show that FLL prevents bone loss and improves bone microstructure by modulating bone and fat balance, suggesting its potential as a therapeutic agent for postmenopausal osteoporosis.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bin Lv, Jinhe Guo, Yaodong Du, Yang Chen, Xin Zhao, Bin Yu, Jiarui Liu, Tianyi Cui, Haoping Mao, Xiaoying Wang, Xiumei Gao
Summary: Respiratory diseases, such as acute lung injury (ALI), have become a global health problem. The excessive activation and recruitment of immunocytes in the lungs, as well as the release of cytokines, are considered the primary causes of ALI. However, the cellular mechanisms involved in ALI remain unknown. Therefore, new therapeutic strategies need to be developed to control inflammation and prevent the worsening of ALI.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Retraction
Endocrinology & Metabolism
Wencheng Zhang, Qilong Wang, Ping Song, Ming-Hui Zou
Article
Plant Sciences
Yang Liu, Rui Shao, Tongchuan Suo, Junjie Zhu, Erwei Liu, Yajing Wang, Lin Miao, Xiumei Gao
Summary: In this study, the effect of DZQE on inflammation-related benign prostatic hyperplasia (BPH) was investigated. The results showed that DZQE can significantly inhibit prostate enlargement and decrease the inflammation index. Furthermore, DZQE was found to suppress inflammation-associated BPH by regulating the ERK1/2 signal through its active components, Tan IIA and Ba.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Microbiology
Xinqin Zhong, Yucui Zhao, Lu Huang, Jiarui Liu, Kaiyue Wang, Xiumei Gao, Xin Zhao, Xiaoying Wang
Summary: In this study, it was demonstrated that L. johnsonii protects cardiac function, delays cardiac pathology, and improves gut barrier integrity by remodeling the gut microbiome. The beneficial effects of L. johnsonii on cardiac function post-AMI were abrogated by microbiome dysbiosis caused by antibiotics. The enrichment of L. johnsonii reshapes the gut microbiome by increasing the abundance of Muribaculaceae, Lactobacillus, and decreasing Romboutsia, Clostridia UCG-014, which are correlated with cardiac traits and serum metabolic biomarkers.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sa Li, Jiaguo Zhan, Yucheng Wang, Patrick Kwabena Oduro, Felix Boahen Owusu, Jiale Zhang, Ling Leng, Ruiqiao Li, Shujie Wei, Jun He, Qilong Wang
Summary: Suxiao Jiuxin Pill (SJP) is an effective traditional Chinese medicine used for heart diseases. This study investigated the pharmacological effects of SJP in acute myocardial infarction (AMI) and the molecular pathways involved in coronary artery vasorelaxation. The results showed that SJP improved cardiac function and elevated ST segment in AMI rat models. Analysis of the compounds in SJP-treated rats' sera detected various non-volatile and volatile compounds. Network pharmacology analysis identified eNOS and PTGS2 as key drug targets, and SJP-induced coronary artery relaxation was mediated through the eNOS-NO pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lan Li, Jiasong Cao, Sheng Li, Tianyi Cui, Jingyu Ni, Han Zhang, Yan Zhu, Jingyuan Mao, Xiumei Gao, Adam C. Midgley, Meifeng Zhu, Guanwei Fan
Summary: Tissue-resident cardiac macrophage subsets play important roles in cardiac tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)-expressing macrophages recruit circulating monocytes to infarcted myocardium and promote inflammation. However, small extracellular vesicles (sEV) derived from CCR2 macrophages, which resemble M2-polarized macrophages, have anti-inflammatory effects and contribute to cardiac repair.
Article
Biochemical Research Methods
Xiaoyan Xu, Meiting Jiang, Xiaohang Li, Yu Wang, Meiyu Liu, Hongda Wang, Yueguang Mi, Boxue Chen, Xiumei Gao, Wenzhi Yang
Summary: We propose the concept of a three-dimensional characteristic chromatogram (3D CC) and use it to authenticate various ginseng products through online comprehensive two-dimensional liquid chromatography (LC x LC) technology. By analyzing the stereo peaks and shade depth in the 3D CC, it is feasible to identify and distinguish different ginseng species and Chinese patent medicines. This provides a practical solution for the accurate identification of easily confused traditional Chinese medicines (TCMs).
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Plant Sciences
Benyu Liu, Shiming Fang, Kun Zhou, Lulu Ma, Yaling Shi, Yuefei Wang, Xiumei Gao
Summary: This study aimed to reveal the hepatotoxicity distinction of coumarin-related compounds from glycosides to aglycones in Fructus Psoraleae (FP) and elucidate their potential mechanism. The results showed that P, IP, FA, and IFA were identified as hepatotoxic compounds, while their glycosides were almost non-hepatotoxic. The conversion from glycosides to aglycones played an essential role in FP-induced hepatotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Wanyu Tong, Ling Leng, Yucheng Wang, Jingwen Guo, Felix Boahen Owusu, Yue Zhang, Fang Wang, Ruiqiao Li, Yuhong Li, Yanxu Chang, Yuefei Wang, Qilong Wang
Summary: This study aimed to investigate the pharmacological effects of Buyang Huanwu decoction (BYHWD) on preventing diabetes-accelerated atherosclerosis and elucidate its underlying mechanism. The results showed that BYHWD treatment reduced mitochondrial fission through modulation of the AMPK/Drp1 pathway, thereby suppressing diabetes-accelerated atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Bian-Xia Xue, Si-Xia Liu, Patrick Kwabena Oduro, Nana Ama Mireku-Gyimah, Li-Hua Zhang, Qilong Wang, Hong-Hua Wu
Summary: Recent studies have shown that the essential oil of Nardostachys jatamansi has potential health benefits, such as reducing blood pressure and protecting the heart. However, the active constituents and molecular mechanisms are still unknown. This study identified the chemical constituents of the essential oil and tested its effects on constricted blood vessels. The findings suggest that Nardostachys jatamansi may have vasodilatory effects and provide insights into its potential therapeutic applications.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Xiumei Gao, Chenyan Wang, Yong Ni, Huiling Zhang
Summary: This study aimed to observe the clinical efficacy of acupuncture along fascia, meridians, and nerves combined with ultrasound-guided nerve blockage in the treatment of postherpetic neuralgia. The results showed that the combination treatment was more effective than ultrasound-guided nerve blockage alone.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2023)
Article
Cell Biology
Jian Li, Hongmin Yao, Fujie Zhao, Junqing An, Qilong Wang, Jing Mu, Zhixue Liu, Ming-Hui Zou, Zhonglin Xie
Summary: PYCARD plays a critical role in miRNA biogenesis and regulates neointima formation by inhibiting CMA-mediated degradation of AGO2, thus promoting microRNA maturation.
