Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

Inhibition of CREB‐mediated ZO‐1 and activation of NF‐κB‐induced IL‐6 by colonic epithelial MCT4 destroys intestinal barrier function

(2019) Shunxian Zhang et al.   CELL PROLIFERATION

DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome

(2018) Kate Joanne Howell et al.   GASTROENTEROLOGY

Targeting endothelial ligands: (ICAM-1/Alicaforsen, MAdCAM-1)

(2018) Walter Reinisch et al.   Journal of Crohns & Colitis

Cytokine Tuning of Intestinal Epithelial Function

(2018) Caroline Andrews et al.   Frontiers in Immunology

Generation of renewable mouse intestinal epithelial cell monolayers and organoids for functional analyses

(2018) Emily C. Moorefield et al.   BMC CELL BIOLOGY

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Anti-Adhesion Therapies in Inflammatory Bowel Disease—Molecular and Clinical Aspects

(2017) Sebastian Zundler et al.   Frontiers in Immunology

Intestinal barrier dysfunction in human necrotizing enterocolitis

(2016) Sarah A. Moore et al.   JOURNAL OF PEDIATRIC SURGERY

Epidermal Growth Factor and Intestinal Barrier Function

(2016) Xiaopeng Tang et al.   MEDIATORS OF INFLAMMATION

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

(2016) R K Boyapati et al.   Mucosal Immunology

pathDIP: an annotated resource for known and predicted human gene-pathway associations and pathway enrichment analysis

(2016) Sara Rahmati et al.   NUCLEIC ACIDS RESEARCH

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

A New Class of Orthosteric uPAR·uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR·Vitronectin Interaction

(2015) Degang Liu et al.   ACS Chemical Biology

Hypothesis setting and order statistic for robust genomic meta-analysis

(2014) Chi Song et al.   Annals of Applied Statistics

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

(2014) Marco Genua et al.   GUT

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Fecal calprotectin in diagnosis and clinical assessment of inflammatory bowel disease

(2014) Taina Sipponen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF

(2013) Roosmarijn E. Vandenbroucke et al.   EMBO Molecular Medicine

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

(2013) Sandra Orchard et al.   NUCLEIC ACIDS RESEARCH

Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions

(2013) Martin H. Schaefer et al.   PLoS Computational Biology

Osteopontin Biomarker in Inflammatory Bowel Disease, Animal Models and Target for Drug Discovery

(2012) Manuela G. Neuman   DIGESTIVE DISEASES AND SCIENCES

Mucosal healing in inflammatory bowel diseases: a systematic review

(2012) Markus F Neurath et al.   GUT

Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice—A Pathway Associated With Ulcerative Colitis

(2011) Rei Kawashima et al.   GASTROENTEROLOGY

The Epithelial Barrier Is Maintained by In Vivo Tight Junction Expansion During Pathologic Intestinal Epithelial Shedding

(2011) Amanda M. Marchiando et al.   GASTROENTEROLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Conformational Regulation of Urokinase Receptor Function

(2011) Henrik Gårdsvoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal barrier function: Molecular regulation and disease pathogenesis

(2009) Katherine R. Groschwitz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical implications of mucosal healing for the management of IBD

(2009) Guillaume Pineton de Chambrun et al.   Nature Reviews Gastroenterology & Hepatology

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-γ and regulates barrier function through effects on apoptosis

(2008) M Schnoor et al.   Mucosal Immunology

PIPs: human protein-protein interaction prediction database

(2008) M. D. McDowall et al.   NUCLEIC ACIDS RESEARCH

Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis

(2008) T. Yamaoka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA