CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment

Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential

(2021) Kota Nakamura et al.   PANCREATOLOGY

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

(2021) Natalia Ochocka et al.   Nature Communications

Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Gliomas

(2021) Zheng Zhao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

Specific Immune Response and Cytokine Production in CD70 Deficiency

(2021) Hassan Abolhassani   Frontiers in Pediatrics

Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in Glioma

(2020) Chuming Tao et al.   Frontiers in Oncology

The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma

(2020) Parvez Vora et al.   Cell Stem Cell

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

The Intratumoral Heterogeneity Reflects the Intertumoral Subtypes of Glioblastoma Multiforme: A Regional Immunohistochemistry Analysis

(2020) Natalie Bergmann et al.   Frontiers in Oncology

Effect of intra‐ and inter‐tumoral heterogeneity on molecular characteristics of primary IDH‐wild type glioblastoma revealed by single‐cell analysis

(2020) Zujian Xiong et al.   CNS Neuroscience & Therapeutics

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

(2020) Nora Feldker et al.   EMBO JOURNAL

Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

(2020) Carsten Riether et al.   NATURE MEDICINE

Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells

(2020) Sandeep Kumar et al.   Journal for ImmunoTherapy of Cancer

Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma

(2020) Alexander F. Haddad et al.   Scientific Reports

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

(2019) Wei Yang et al.   Science Translational Medicine

An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells

(2019) Valentina Perotti et al.   ONCOGENE

Fratricide-resistant CD1a-specific CAR T-cells for the treatment of cortical T-cell acute lymphoblastic leukemia

(2019) Diego Sánchez-Martínez et al.   BLOOD

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

High Serum Soluble CD27 Level Correlates with Poor Performance Status and Reduced Survival in Patients with Advanced Lung Cancer

(2019) Jumpei Kashima et al.   ONCOLOGY

Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2

(2019) Christelle Bouchart et al.   Cancer Medicine

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016

(2019) Quinn T Ostrom et al.   NEURO-ONCOLOGY

CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness

(2019) Shingo Inaguma et al.   JOURNAL OF PATHOLOGY

Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

(2019) Sangeeta Goswami et al.   NATURE MEDICINE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis

(2018) K.H. Simons et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Analysis of immunobiologic markers in primary and recurrent glioblastoma

(2018) Maryam Rahman et al.   JOURNAL OF NEURO-ONCOLOGY

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

(2018) Matthew L Cooper et al.   LEUKEMIA

An anatomic transcriptional atlas of human glioblastoma

(2018) Ralph B. Puchalski et al.   SCIENCE

Breast cancer stem cells characterized by CD70 expression preferentially metastasize to the lungs

(2018) Li Liu et al.   Breast Cancer

Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells

(2018) Shojiro Kitajima et al.   Oncotarget

The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres

(2018) Andrew S. Gilder et al.   Scientific Reports

Immune Microenvironment in Glioblastoma Subtypes

(2018) Zhihong Chen et al.   Frontiers in Immunology

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

(2018) Asami Hanazawa et al.   Frontiers in Immunology

Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy

(2018) Michele Patrizii et al.   Frontiers in Oncology

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Circulating sCD27 and sCD30 in pre-diagnostic samples collected fifteen years apart and future non-Hodgkin lymphoma risk

(2018) Mark P. Purdue et al.   INTERNATIONAL JOURNAL OF CANCER

EMT: A mechanism for escape from EGFR-targeted therapy in lung cancer

(2018) Eugene Tulchinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SWIM tool application to expression data of glioblastoma stem-like cell lines, corresponding primary tumors and conventional glioma cell lines

(2018) Giulia Fiscon et al.   BMC BIOINFORMATICS

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Tumor associated CD70 expression is involved in promoting tumor migration and macrophage infiltration in GBM

(2017) Haitao Ge et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

(2017) Roger Stupp et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis

(2017) Myra E. van Linde et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular markers in glioma

(2017) Kirsten Ludwig et al.   JOURNAL OF NEURO-ONCOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

CD70, a novel target of CAR T-cell therapy for gliomas

(2017) Linchun Jin et al.   NEURO-ONCOLOGY

Reoperation for Recurrent Glioblastoma Multiforme

(2017) Adam M. Robin et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity

(2017) Nan Guo Ring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

CD70 limits atherosclerosis and promotes macrophage function

(2017) Dirk Lievens et al.   THROMBOSIS AND HAEMOSTASIS

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

(2017) Traver Hart et al.   G3-Genes Genomes Genetics

The Role of Hypoxia in Glioblastoma Invasion

(2017) Ana Monteiro et al.   Cells

Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma

(2016) Fanghui Lu et al.   CANCER CELL

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

(2016) Qiong J. Wang et al.   CLINICAL CANCER RESEARCH

Therapeutic targeting of CD70 and CD27

(2016) Harald Wajant   EXPERT OPINION ON THERAPEUTIC TARGETS

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

(2016) Anna Segerman et al.   Cell Reports

Melanoma-expressed CD70 is involved in invasion and metastasis

(2015) Christine Pich et al.   BRITISH JOURNAL OF CANCER

Spatiotemporal Evolution of the Primary Glioblastoma Genome

(2015) Jinkuk Kim et al.   CANCER CELL

Expression of the immune regulation antigen CD70 in osteosarcoma

(2015) Jens Pahl et al.   Cancer Cell International

SRPX2 Enhances the Epithelial–Mesenchymal Transition and Temozolomide Resistance in Glioblastoma Cells

(2015) Haitao Tang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Smart CARs engineered for cancer immunotherapy

(2015) Saul J. Priceman et al.   CURRENT OPINION IN ONCOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Unlocking the potential of CD70 as a novel immunotherapeutic target for non-small cell lung cancer

(2015) Julie Jacobs et al.   Oncotarget

The Evidence of Glioblastoma Heterogeneity

(2015) Akio Soeda et al.   Scientific Reports

Precursor States of Brain Tumor Initiating Cell Lines Are Predictive of Survival in Xenografts and Associated with Glioblastoma Subtypes

(2015) Carlo Cusulin et al.   Stem Cell Reports

Interaction of tumor cells with infiltrating lymphocytes via CD70 and CD27 in clear cell renal cell carcinoma

(2015) Melanie Ruf et al.   OncoImmunology

CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets

(2014) M. T. M. Vossen et al.   JOURNAL OF IMMUNOLOGY

Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses

(2014) Atef Allam et al.   JOURNAL OF IMMUNOLOGY

TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma

(2014) Z-Z Yang et al.   LEUKEMIA

Adoptive Cell Therapies for Glioblastoma

(2013) Kevin Bielamowicz et al.   Frontiers in Oncology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth

(2012) C. Claus et al.   CANCER RESEARCH

Distinctive Features of the Differentiated Phenotype and Infiltration of Tumor-Reactive Lymphocytes in Clear Cell Renal Cell Carcinoma

(2012) Q. J. Wang et al.   CANCER RESEARCH

Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma

(2012) Richard A. Morgan et al.   HUMAN GENE THERAPY

IL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease

(2012) Byung S Kim et al.   Journal of Neuroinflammation

A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme

(2012) Pål A. Rønning et al.   NEURO-ONCOLOGY

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

(2011) D. R. Shaffer et al.   BLOOD

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

The M1 form of tumor-associated macrophages in non-small cell lung cancer is positively associated with survival time

(2010) Junliang Ma et al.   BMC CANCER

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

Role of CD27/CD70 pathway of activation in immunity and tolerance

(2010) Julie Denoeud et al.   JOURNAL OF LEUKOCYTE BIOLOGY

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

(2010) A Singh et al.   ONCOGENE

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

(2009) Martijn A. Nolte et al.   IMMUNOLOGICAL REVIEWS

The transcriptional network for mesenchymal transformation of brain tumours

(2009) Maria Stella Carro et al.   NATURE

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

CD70 as a therapeutic target in human malignancies

(2008) Iqbal S Grewal   EXPERT OPINION ON THERAPEUTIC TARGETS

Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index

(2008) C. F. McDonagh et al.   MOLECULAR CANCER THERAPEUTICS