Dual Kinase Inhibition of EGFR/HER2: Design, Synthesis and Molecular Docking of Thiazolylpyrazolyl‐Based Aminoquinoline Derivatives as Anticancer Agents**

Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives

(2021) Eman Y. Ahmed et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

VEGFR-2 inhibiting effect and molecular modeling of newly synthesized coumarin derivatives as anti-breast cancer agents

(2020) Eman Y. Ahmed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Properties of FDA-approved small molecule protein kinase inhibitors

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Design and molecular modeling of novel P38α MAPK inhibitors targeting breast cancer, synthesized from oxygen heterocyclic natural compounds

(2019) Omaima M. Abdelhafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis

(2019) Tahia K. Mohamed et al.   BIOORGANIC CHEMISTRY

Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers

(2019) Souad A. Elmetwally et al.   BIOORGANIC CHEMISTRY

Synergistic Effect of Α-Solanine and Cisplatin Induces Apoptosis and Enhances Cell Cycle Arrest in Human Hepatocellular Carcinoma Cells

(2019) Sherien M. El-Daly et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors

(2019) Belgin Sever et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer

(2017) Xin Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

An overview of quinoline as a privileged scaffold in cancer drug discovery

(2017) Robert Musiol   Expert Opinion on Drug Discovery

3-Substituted-4-hydroxycoumarin as a new scaffold with potent CDK inhibition and promising anticancer effect: Synthesis, molecular modeling and QSAR studies

(2016) Nehad A. Abdel Latif et al.   BIOORGANIC CHEMISTRY

miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling

(2016) Sherien M. El-Daly et al.   Scientific Reports

Design, synthesis and anticancer activity of furochromone and benzofuran derivatives targeting VEGFR-2 tyrosine kinase

(2015) Omaima M. Abdelhafez et al.   RSC Advances

Design, synthesis and anticancer activity of benzofuran derivatives targeting VEGFR-2 tyrosine kinase

(2014) Omaima M. Abdelhafez et al.   RSC Advances

Lapatinib induces p27Kip1-dependent G₁ arrest through both transcriptional and post-translational mechanisms

(2013) Lin Tang et al.   CELL CYCLE

Photodynamic therapeutic effect of indocyanine green entrapped in polymeric nanoparticles and their anti-EGFR-conjugate in skin cancer in CD1 mice

(2013) Amira M. Gamal-Eldeen et al.   Photodiagnosis and Photodynamic Therapy

Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors

(2012) Ke-Ming Qiu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents

(2012) Hai-Hong Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Effect of Vorinostat on the Development of Resistance to Doxorubicin in Neuroblastoma

(2012) Timothy B. Lautz et al.   PLoS One

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Design, synthesis and biological evaluation of thiazolidinone derivatives as potential EGFR and HER-2 kinase inhibitors

(2009) Peng-Cheng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Development of HKI‐272 and Related Compounds for the Treatment of Cancer

(2008) Allan Wissner et al.   ARCHIV DER PHARMAZIE