Article
Chemistry, Physical
Sha Li, Xing Hu, Junhui Pan, Deming Gong, Guowen Zhang
Summary: The study showed that apigenin reversibly inhibited pancreatic lipase activity in a competitive manner, and exhibited a synergistic effect when combined with orlistat. The formation of a complex between apigenin and pancreatic lipase driven by hydrogen bonds resulted in the inhibition of enzyme activity through a static manner. The research provided novel insights into the mechanism of apigenin as a pancreatic lipase inhibitor.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Food Science & Technology
Mahsa Nayebhashemi, Somayeh Enayati, Mozhgan Zahmatkesh, Hamid Madanchi, Samaneh Saberi, Ehsan Mostafavi, Esmat Mirbzadeh Ardakani, Mohammad Azizi, Vahid Khalaj
Summary: Inhibition of lipid absorption is an effective strategy in obesity treatment. Pancreatic Lipase inhibitor (PLI) peptides, as novel anti-obesity agents, were expressed in Saccharomyces boulardii using a yeast surface display system. The recombinant probiotics showed dose-dependent PL inhibition in vitro and significant weight loss and reduced serum lipids in a rat model of obesity, indicating their potential application in treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Plant Sciences
Xiao-yan Qin, Zi-chang Niu, Xiao-ling Han, Yun Yang, Qiu Wei, Xiao-xue Gao, Ran An, Li-feng Han, Wen-zhi Yang, Li-juan Chai, Er-wei Liu, Xiu-mei Gao, Hao-ping Mao
Summary: Our study indicated that EZF significantly inhibited the bone loss induced by OVX in mice through regulation of estradiol combined with the nourishing effect of the uterus, and it also attenuated bone resorption by decreasing the RANKL/OPG ratio to inhibit osteoclast maturation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Jianchao Li, Kaiyi Wu, Ying Zhong, Jiangying Kuang, Nana Huang, Xin Guo, Hang Du, Chong Guo, Rongrong Li, Xiaomin Zhu, Tianyu Zhang, Liping Gong, Lisong Sheng, Rong Sun
Summary: Si-Ni-San (SNS), a famous Chinese herbal formula, has therapeutic effects on obesity by improving lipid accumulation through the AMPK signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bilal Ahmad, Emily P. Friar, Emerald Taylor, Muhammad Sufyan Vohra, Christopher J. Serpell, Michelle D. Garrett, Jason Siau Ee Loo, Isabel Lim Fong, Eng Hwa Wong
Summary: In this study, the anti-obesity effects of two flavones (PMF and TMF) were evaluated through inhibition of pancreatic lipase and inhibition of adipogenesis. Both flavones competitively inhibited pancreatic lipase activity and reduced lipid accumulation in adipocytes. They also downregulated the expression of adipogenic and lipogenic genes and upregulated the expression of lipolytic genes. Overall, PMF was found to be a more potent inhibitor of both pancreatic lipase activity and adipogenesis compared to TMF. These findings suggest that PMF and TMF have anti-obesity activities and should be further investigated.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Shaofeng Xiong, Shumin Yu, Kun Wang, Xiaowei Xiong, Min Xia, Guohua Zeng, Qiren Huang
Summary: In this study, the effects of AP on glycolipid metabolism, browning, and autophagy were investigated using a mouse obesity model and a preadipocyte induction model in vitro. The results showed that AP treatment alleviated body weight, glycolipid metabolic disorder, and insulin resistance through autophagy inhibition and promotion of fat-browning. These findings suggest that autophagy inhibition promotes browning of white adipocytes and highlight the potential of AP in preventing and treating obesity and associated metabolic disorders.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Food Science & Technology
Rong Li, Songzuo Yu, Xiao Liang, Yu Li, Keng Po Lai
Summary: Using a network pharmacology approach and molecular docking analysis, this study explores the pharmacological mechanism of vitamin C (VC) in reducing cadmium-induced fracture. The study identifies 17 intersection targets of VC and cadmium-induced fracture, and reveals that VC exerts effective binding capacity in cadmium-induced fracture. Furthermore, the study identifies the biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biology
Jia-jun Luo, Xin-hua Chen, Peng-ying Liang, Zean Zhao, Ting Wu, Zhong-huang Li, Shan-he Wan, Jian Luo, Jian-xin Pang, Jia-jie Zhang, Yuan-xin Tian
Summary: This study revealed the core targets and molecular mechanisms of Isobavachin in the treatment of hyperuricemia through network pharmacology and molecular docking. Isobavachin was found to regulate pathways including drug metabolism-other enzymes, metabolic pathways, bile secretion, renin-angiotensin system, and renin secretion. The bile secretion pathway regulated by ABCG2 may be a novel pathway.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Ru Wang, Jia Zeng, Lu Chen, Lianlian Sun, Yihai Wang, Jingwen Xu, Xiangjiu He
Summary: The study found that WT-29 isolated from Wedelia exhibits anti-inflammatory and anti-allergic effects mainly through the regulation of NF kappa B, MAPK pathways, and autophagy. This suggests that WT-29 may have potential as an anti-inflammatory and anti-allergic agent, and could be used as a medicine or health benefit product.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Applied
Wenya Jiao, Si Mi, Yaxin Sang, Qiuxia Jin, Bimal Chitrakar, Xianghong Wang, Shuo Wang
Summary: This study investigated the anti-obesity effect of 6-shogaol through network pharmacology and experimental validation, identifying key targets and pathways. The findings showed that 6-shogaol significantly inhibited proliferation and differentiation of adipocytes, suggesting potential for developing novel anti-obesity products.
Article
Pharmacology & Pharmacy
Kwang-Il To, Zhen-Xing Zhu, Ya-Ni Wang, Gang-Ao Li, Yu-Meng Sun, Yang Li, Ying-Hua Jin
Summary: This study investigated the drug targets and pathways of Ginsenoside Rh4 (G-Rh4) in treating inflammation using network pharmacology and experimental approaches. The results showed that G-Rh4 may exert anti-inflammatory effects through the JAK-STAT signaling pathway, TNF signaling pathway, NF-kappa B signaling pathway, and PI3K-Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Naiqiang Zhu, Jingyi Hou
Summary: Inflammation, a protective response against infection and injury, involves a variety of biological processes. Sophorae Flavescentis (Kushen) is a promising Traditional Chinese Medicine (TCM) for treating inflammation, and it may mediate inflammation mainly through IL-6, IL-1 beta, VEGFA, TNF-alpha, and PTGS2 (COX-2), as well as the NF-kappa B signaling pathways. The pharmacological mechanism of Kushen's anti-inflammatory effect needs further research.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Shuhan Li, Zizhao Wang, Zhengnan Zhou, Zhiyuan Gao, Yuai Liu, Jie Li, Xingbang Gao, Jing Liu, Hanbing Liu, Qian Xu
Summary: This study investigated the therapeutic effect of apigenin on hyperlipidemia using network pharmacology and molecular docking strategy, and explored the potential targets of apigenin in the treatment of hyperlipidemia. Genetic Ontology Biological Process (GOBP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway enrichment analysis were performed on the common targets. Molecular docking was used to predict the binding mode of apigenin to the target. Sprague Dawley rats were used to establish a hyperlipidemia model, and the expression levels of INS and VEGFA mRNA were detected.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biology
Ying Hu, Wei Yuan, Na Cai, Kun Jia, Yunlong Meng, Fei Wang, Yurui Ge, Huiqiang Lu
Summary: This study investigated the pharmacological mechanisms of quercetin in osteoporosis using network pharmacology strategy and zebrafish model. The results identified several signaling pathways that may be involved in the anti-osteoporosis effects of quercetin. Molecular docking experiments and animal validation confirmed these findings.
Article
Nutrition & Dietetics
Xiao-Ya Qin, Xu-Dong Hou, Guang-Hao Zhu, Yuan Xiong, Yun-Qing Song, Liang Zhu, Dong-Fang Zhao, Shou-Ning Jia, Jie Hou, Hui Tang, Guang-Bo Ge
Summary: This study discovers human pancreatic lipase inhibitors from edible herbal medicines, specifically from Ampelopsis grossedentata extract. The study identifies and characterizes the inhibitory mechanisms of these inhibitors, which offer support for their anti-obesity and lipid-lowering effects. The study also highlights the importance of finding effective inhibitors against human pancreatic lipase.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Fuqiang Liang, Yajing Fang, Weiwei Cao, Zhuo Zhang, Siyi Pan, Xiaoyun Xu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Agriculture, Multidisciplinary
Yajing Fang, Mengmeng Xia, Fuqiang Liang, Weiwei Cao, Siyi Pan, Xiaoyun Xu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Fuqiang Liang, Weiwei Cao, Yuting Huang, Yajing Fang, Yuxin Cheng, Siyi Pan, Xiaoyun Xu
Article
Biochemistry & Molecular Biology
Mengmeng Xia, Yajing Fang, Weiwei Cao, Fuqiang Liang, Siyi Pan, Xiaoyun Xu
Article
Entomology
Jiayi Shi, Tai Zhang, Tingting Wang, Fuqiang Liang
JOURNAL OF STORED PRODUCTS RESEARCH
(2020)
Article
Food Science & Technology
Fuqiang Liang, Yumeng Shi, Jiayi Shi, Tai Zhang, Ran Zhang
Summary: Novel ACE inhibitory peptide IAF from pumpkin seed proteins showed significant inhibition ability by forming stabilization complex, suggesting a promising candidate for controlling hypertension.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Tai Zhang, Jiayi Shi, Fuqiang Liang, Yumeng Shi, Ran Zhang
Summary: This study examined the effects of rice glutelin digestion during storage on its biological activity and ability to modulate the gut microbiota. The results showed that after 2 days of storage, the glutelin's structural changes led to enhanced biological activity and increased abundance of certain bacterial species in the gut. However, prolonged storage resulted in decreased biological activity and changes in the composition of gut microbiota. Overall, the stability of glutelin structure played a crucial role in its biological activity and modulation of gut microbiota.
JOURNAL OF CEREAL SCIENCE
(2022)
Article
Chemistry, Applied
Fuqiang Liang, Yumeng Shi, Jiayi Shi, WeiWei Cao
Summary: This study investigated the interaction between apigenin and pumpkin seed protein (PSP) using multi-spectroscopic analysis and molecular simulation approaches. The results showed that apigenin interacted with PSP through hydrophobic interactions. Molecular docking and molecular dynamics simulations revealed that apigenin maintained binding stability in the hydrophobic pockets of the protein. The interaction induced changes in the protein's structure and conformation. This study provides theoretical evidence for the potential application of PSP and apigenin complex products in the food industry.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Yuxin Cheng, Ting Wu, Shuxin Tang, Fuqiang Liang, Yajing Fang, Weiwei Cao, Siyi Pan, Xiaoyun Xu