Review
Biotechnology & Applied Microbiology
You Zhou, Yuqing Dong, Aixue Zhang, Jibin Wu, Qiang Sun
Summary: Mesenchymal stem cells (MSCs) and their secreted exosomes have been found to play an important role in the initiation and development of tumors. Nanobiotechnology and bioengineering technology have been utilized to detect and modify exosomes for cancer diagnosis and treatment. These modified exosomes can carry drugs, proteins, and RNAs to cancer cells, exhibiting unique properties such as targeting ability, low immunogenicity, flexibility in modification, and high biological barrier permeability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Endocrinology & Metabolism
Jiachao Xiong, Hao Hu, Rong Guo, Hui Wang, Hua Jiang
Summary: Diabetes mellitus is a metabolic disease characterized by high blood sugar levels, often accompanied by various complications. Mesenchymal stem cell exosomes possess repair functions, low immunogenicity, and ease of storage and transportation, making them a potentially effective treatment for diabetes and its complications.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Mengmeng Yang, Jun Chen, Li Chen
Summary: Diabetes is a metabolic disease characterized by chronic hyperglycemia, which can lead to various complications. Traditional treatments only alleviate symptoms and do not prevent complications. Mesenchymal stem cell-derived exosomes are considered a new approach for treating diabetes and its complications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Nesrine Ebrahim, Heba Elsayed Abd El-Halim, Omayma Kamel Helal, Nahla El-Eraky El-Azab, Omnia A. M. Badr, Amira Hassouna, Hajir A. Al Saihati, Nashwa Hassan Aborayah, Hanan Tawfeek Emam, Hend S. El-wakeel, Mohammad Aljasir, Mohamed El-Sherbiny, Naglaa A. S. Sarg, Gehan Ahmed Shaker, Ola Mostafa, Dina Sabry, Marwa Abdel Kader Fouly, Nicholas Robert Forsyth, Nehal M. Elsherbiny, Rabab F. Salim
Summary: The study indicated that BM-MSCs-Ex reduced oxidative stress, inflammation, and angiogenesis in diabetic retinas by inhibiting the Wnt/β-catenin signaling pathway, ultimately improving DR features.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova, Jan Rosocha
Summary: Mesenchymal stem cells (MSCs) are shown to have great potential in treating diseases through the secretion of exosomes, which are believed to be more effective than the cells themselves. Alternative approaches using MSC-derived exosomes offer promise in overcoming limitations in cell-based therapy. MSC-derived exosomes have significant therapeutic potential and are promising in regenerative medicine.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Cell Biology
Hongxia Yu, Yuling Huang, Lina Yang
Summary: This study reviewed the application of mesenchymal stem cells and their exosomes in cartilage regeneration, providing a new idea for the treatment of osteoarthritis.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell Biology
Yusha Chen, Xuefeng Liu, Zhaohui Tong
Summary: Radiation-induced pulmonary fibrosis (RIPF) is a fatal side effect of radiotherapy without effective clinical intervention. Mesenchymal stromal cells (MSCs) have shown promise in treating RIPF due to their abilities and paracrine effects. However, challenges in applying MSCs need to be addressed. This review discusses the mechanisms and challenges of MSCs in treating RIPF.
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Yuxiang Zhang, Wei Ju, Hong Zhang, Liu Mengyun, Weiliang Shen, Xiao Chen
Summary: Tendinopathy is a disease caused by the degeneration of tendon tissue, and currently, there is no treatment available to prevent or delay its progression. Recent research suggests that MSCs-derived exosomes (MSCs-exos) may be useful for promoting tendon healing and could be considered as a potential treatment for tendinopathy.
STEM CELL RESEARCH & THERAPY
(2023)
Retraction
Cell & Tissue Engineering
Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang, Xuexi Wang
Summary: The article has been retracted. More details can be found in the Retraction Notice at https://doi.org/10.1186/s13287-019-1149-5.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Michiko Horiguchi, Yuko Okada, Yuya Turudome, Kentaro Ushijima
Summary: Type 1 diabetes mellitus leads to degeneration of organelles in adipose-derived stem cells, with the main characteristic being prominent enlarged spherical vesicles. The exosomes of T1DM ADSCs are found to be enlarged, reduced in number, and increased in the percentage positive for tetraspanin CD9, providing insight into the characteristics of stem cells in patients with type 1 diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Seng Kar Yap, Kian Leong Tan, Nor Yasmin Abd Rahaman, Nur Fazila Saulol Hamid, Der Jiun Ooi, Yin Sim Tor, Qi Hao Daniel Looi, Li Kar Stella Tan, Chee Wun How, Jhi Biau Foo
Summary: The study demonstrates that low-dose hUC-MSCs-sEVs treatment has positive effects on human skeletal muscle cells and type 2 diabetes mellitus rats, improving glucose tolerance and protecting against organ damage. hUC-MSCs-sEVs could be a potential therapy for diabetes mellitus.
Review
Cell & Tissue Engineering
Yao Sun, Guoliang Liu, Kai Zhang, Qian Cao, Tongjun Liu, Jiannan Li
Summary: Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. Researchers have increasingly focused on using exosomes for drug delivery, especially MSC-EXOs, due to their immune properties, tumor-homing properties, and elastic properties. This review article summarizes the characteristics of MSC-EXOs and introduces production, purification, and drug loading methods to address existing problems and provide suggestions for future studies.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Hasaan Hayat, Hanaan Hayat, Bennett Francis Dwan, Mithil Gudi, Jack Owen Bishop, Ping Wang
Summary: This review highlights the important role of CSCs in altering the cellular microenvironment to favor cancer progression, as well as the development of novel interventions targeting CSCs for cancer therapy.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: This review article summarizes the therapeutic effects and mechanisms of mesenchymal stem cells (MSC) and their exosomes (MSC-Exos) in the treatment of inflammatory eye diseases and ocular graft-versus-host disease (oGVHD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Lei Liu, Mengmeng Jin, Qing Tao, Li Yu, Jian Du, Cong Wang, Qingli Luo, Tian Xing, Yuanhong Xu, Jilong Shen, Deyong Chu
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Parasitology
Qing Tao, Xianhe Wang, Lei Liu, Yongsheng Ji, Qingli Luo, Jian Du, Li Yu, Jilong Shen, Deyong Chu