Article
Oncology
Jiannan Ren, Haixin Yu, Wei Li, Xin Jin, Bin Yan
Summary: This study revealed that CBX7 is downregulated in bladder cancer and EZH2 represses CBX7 expression through increased H3K27me3. Additionally, CBX7 directly downregulates FGFR3 expression and sensitizes bladder cancer cells to cisplatin treatment.
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Mengbiao Guo, Yuanyan Xiong
Summary: The CRISPR-Cas9 system is widely used for gene editing and clinical applications. However, it can cause off-target effects. This study found significant sex differences in p53-associated Cas9 activities. Further analysis revealed sex-specific dependencies of gene knockouts in different cancer types, potentially mediated by transcriptional factors. These findings suggest the need to consider the p53-dependent sex bias in future CRISPR-Cas9 clinical applications, especially in cancer.
Review
Biochemistry & Molecular Biology
Guan-Jun Dong, Jia-Le Xu, Yu-Ruo Qi, Zi-Qiao Yuan, Wen Zhao
Summary: Polycomp group (PcG) proteins are highly conserved multiprotein complexes that play a role in gene transcriptional repression during development and various physiological and pathological processes. This review focuses on the transcriptional regulation of PcG proteins, their oncogenic and tumor-suppressive roles, and the research progress of inhibitors targeting PcG proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhengnan Huang, Yilin Yan, Zhen Zhu, Jiakuan Liu, Xiao He, Sumiya Dalangood, Meiqian Li, Mingyue Tan, Jinming Cai, Pengfei Tang, Ruimin Huang, Bing Shen, Jun Yan
Summary: CBX7 is frequently downregulated in urinary bladder cancer due to promoter hypermethylation, leading to poor prognosis. Its ectopic expression suppresses UBC cell aggressiveness and tumor development by downregulating AKR1B10 and inactivating ERK signaling, providing a potential therapeutic target against UBC.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Xinxin Li, Lili Li, Xi Xiong, Qihui Kuang, Min Peng, Kai Zhu, Pengcheng Luo
Summary: The expression levels of CBX6 and CBX7 may help predict the prognosis of bladder cancer patients. CBX6 may contribute to a poor prognosis by inhibiting M1 polarization and promoting Treg recruitment in the tumor microenvironment, while CBX7 may contribute to a better prognosis by increasing resting mast cell numbers and decreasing macrophage M0 content.
Review
Plant Sciences
Qingshuai Chen, Kui Liu, Ru Yu, Bailing Zhou, Pingping Huang, Zanxia Cao, Yaoqi Zhou, Jihua Wang
Summary: Long non-coding RNAs (lncRNAs) play vital roles in various biological functions in plant growth and development, interacting with other molecules through roles such as sequestering RNA or DNA, recruiting or hijacking transcription factors, and binding with chromatin modification complexes. So far, 73 lncRNA-molecule interaction pairs have been validated in 16 plant species, indicating the commonality of these regulatory roles in the plant kingdom.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Oncology
Xiao Li, Jinpeng Li, Liming Xu, Wei Wei, Anyi Cheng, Lingxian Zhang, Mengna Zhang, Gaosong Wu, Cheguo Cai
Summary: CDK16 is highly expressed in breast cancer, especially in triple-negative breast cancer (TNBC). The elevated expression of CDK16 is associated with poor outcomes in breast cancer patients. CDK16 can enhance the proliferation and migration ability of TNBC cells in vitro, and promote tumor growth and metastasis in vivo. Both genetic knockdown and pharmacological inhibition of CDK16 significantly suppress the tumor progression of TNBC. Mechanistically, CDK16 exerts its function by phosphorylating protein regulator of cytokinesis 1 (PRC1) to regulate spindle formation during mitosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Multidisciplinary Sciences
Mark Helm, Yuri Motorin
Summary: For the first time, a comprehensive study has described the phosphorylation in the core of a transfer RNA molecule and characterized the enzymes responsible for adding and removing the phosphate group.
Review
Cell Biology
Man Wang, Fei Yu, Yuan Zhang, Lei Zhang, Wenguang Chang, Kun Wang
Summary: Chemoresistance is a major clinical problem in GI cancer treatment, and the underlying mechanisms are still unclear. Recent studies have shown that circRNAs play a key role in GI cancer chemoresistance, acting as molecular sponges to indirectly control gene expression. Hence, circRNAs may serve as therapeutic targets for overcoming GI cancer drug resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Jiali Wang, Tiangong Wang, Shiyun Hu, Jinyun Li, Chao Ni, Meng Ye
Summary: In this study, we identified that hsa_circ_0043278 was significantly downregulated in colorectal cancer tumor samples (P < 0.0001) and cell lines (P < 0.05). The area under the receiver operating characteristic curve was 0.71, showing a sensitivity of 0.72 and specificity of 0.70 (P = 0.0006). Moreover, overexpression of hsa_circ_0043278 inhibited proliferation and migration while promoting apoptosis in colorectal cancer cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sijing Li, Omar Motino, Flavia Lambertucci, Isabelle Martins, Li Sun, Guido Kroemer
Summary: PRC1 is a protein regulator involved in cytokinesis, and it has been found to be associated with multiple cancers. In tumor tissues of 28 cancer types, PRC1 is expressed at higher levels compared to non-malignant tissues. Overexpression of PRC1 indicates poor prognosis, especially in ACC, LGG, KIRP, LICH, LUAD, MESO, PAAD, SARC, and UCEC. Methylation of the PRC1 gene at certain sites is associated with favorable prognosis in ACC, KIRP, LUAD, MESO, KIRP, and LGG.
Editorial Material
Biochemistry & Molecular Biology
Mary Williard Elting
Summary: The study shows how the mitotic crosslinker PRC1 can adjust its behavior to regulate the speed of microtubule sliding, contributing to the assembly of the mitotic spindle.
Article
Cell Biology
Yining Hao, Yu Zhu, Fukang Sun, Danfeng Xu, Chenghe Wang
Summary: miR-30c-5p is significantly downregulated in bladder cancer (BCa) and is associated with unfavorable TNM stages and poor prognosis. It exerts its function in BCa by suppressing its target gene PRC1. Thus, miR-30c-5p has the potential to be a valuable biomarker for predicting clinical outcomes in BCa patients.
CELLULAR SIGNALLING
(2023)
Review
Immunology
Zeyu Wu, Xiao Yu, Shuijun Zhang, Yuting He, Wenzhi Guo
Summary: This article summarizes the mechanisms underlying aberrant circRNA expression in the TME of digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Handong Huang, Lu Li, Kunming Wen
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in cellular processes, particularly in the pathogenesis of diseases like cancer. Interactions between lncRNAs and RNA-binding proteins (RBPs) are essential for understanding cancer pathogenesis and developing effective therapies.
Article
Clinical Neurology
Pei Zhang, M. Helmy Selim, Haiyan Wang, Wei Kuang, Miaojing Wu, Chenxing Ji, Guowen Hu, Lei Wu, Xingen Zhu, Hua Guo
WORLD NEUROSURGERY
(2019)
Article
Surgery
Xiangyu Sun, Zhou Liu, M. H. Selim, Yong Huang
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2019)
Article
Clinical Neurology
Kangmin He, M. H. S. Alriashy, Zhen Fan, Nidan Qiao, Yujun Liao, Qingzhu An, Bin Xu, Jianping Song, Xin Zhang, Wei Zhu, Liang Chen, Ying Mao
Summary: This study aimed to explore a treatment protocol for patients with mesial temporal cerebral cavernoma (MTC)-associated epilepsy. Through analyzing the patients admitted to their center, the research team found that comprehensive preoperative and intraoperative assessments could help patients choose a suitable surgical time and maximize the benefits between seizure control and cognition protection.
WORLD NEUROSURGERY
(2022)
Review
Oncology
Lin Zhou, Taohui Ouyang, Meihua Li, Tao Hong, Alriashy Mhs, Wei Meng, Na Zhang
Summary: USP7, the largest family of deubiquitinating enzymes, plays a vital role in regulating physiological and pathological processes, with aberrant expression and activity in cancers. Targeting USP7 could be an attractive therapeutic approach in cancer treatment, emphasizing the importance of further research on USP7-related biological processes and cancer.
FRONTIERS IN ONCOLOGY
(2021)