Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells

Epidemiology of COVID-19 in Mexico, symptomatic profiles and presymptomatic people

(2021) Miguel A. Fernández-Rojas et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Covid-19: What new variants are emerging and how are they being investigated?

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Characterisation of the first 250 000 hospital admissions for COVID-19 in Brazil: a retrospective analysis of nationwide data

(2021) Otavio T Ranzani et al.   Lancet Respiratory Medicine

Toll-Like Receptor 2 (TLR2) Knockout Abrogates Diabetic and Obese Phenotypes While Restoring Endothelial Function via Inhibition of NOX1

(2021) Zhen Guo et al.   DIABETES

Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation

(2021) Kai Huang et al.   HYPERTENSION

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

(2020) Haijun Zhang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

(2020) Joan C. Smith et al.   DEVELOPMENTAL CELL

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19

(2020) Janice M. Leung et al.   EUROPEAN RESPIRATORY JOURNAL

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

(2020) Giacomo Grasselli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessing ACE2 expression patterns in lung tissues in the pathogenesis of COVID-19

(2020) Guoping Li et al.   JOURNAL OF AUTOIMMUNITY

Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?

(2020) Murray Esler et al.   JOURNAL OF HYPERTENSION

Elevated Interleukin‐6 and Severe COVID‐19: A Meta‐Analysis

(2020) Muhammad Aziz et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

(2020) Nicole M Kuderer et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sex difference and smoking predisposition in patients with COVID-19

(2020) Hua Cai   Lancet Respiratory Medicine

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?

(2020) Lei Fang et al.   Lancet Respiratory Medicine

Proportion of asymptomatic coronavirus disease 2019: A systematic review and meta‐analysis

(2020) Jingjing He et al.   JOURNAL OF MEDICAL VIROLOGY

Sex differential in COVID-19 mortality varies markedly by age

(2020) Sunil S Bhopal et al.   LANCET

Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality, in a cohort of patients with COVID-19 in the Bronx, New York

(2020) Leonidas Palaiodimos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

A dynamic COVID-19 immune signature includes associations with poor prognosis

(2020) Adam G. Laing et al.   NATURE MEDICINE

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

(2020) Aubin Moutal et al.   PAIN

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response

(2020) Arunima Purkayastha et al.   Cell Stem Cell

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Tocilizumab for Covid-19 — The Ongoing Search for Effective Therapies

(2020) Edmund Huang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

(2020) Carlos Salama et al.   NEW ENGLAND JOURNAL OF MEDICINE

Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

(2020) Naoki Kaneko et al.   STROKE

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

(2020) Hannah Peckham et al.   Nature Communications

Pseudo-likelihood based logistic regression for estimating COVID-19 infection and case fatality rates by gender, race, and age in California

(2020) Di Xiong et al.   Epidemics

Covid-19: New coronavirus variant is identified in UK

(2020) Jacqui Wise   BMJ-British Medical Journal

Covid-19: What have we learnt about the new variant in the UK?

(2020) Elisabeth Mahase   BMJ-British Medical Journal

Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics

(2020) Kai Huang et al.   Redox Biology

Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein

(2020) Gerard J. Nuovo et al.   Annals of Diagnostic Pathology

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells

(2020) Yuichiro J. Suzuki et al.   VASCULAR PHARMACOLOGY

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

(2019) Yixuan Zhang et al.   Nature Reviews Cardiology

Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

(2018) Chen Wang et al.   LANCET

Novel Treatment of Hypertension by Specifically Targeting E2F for Restoration of Endothelial Dihydrofolate Reductase and eNOS Function Under Oxidative Stress

(2018) Hong Li et al.   HYPERTENSION

Smoking in Italy in 2015-2016: Prevalence, Trends, Roll-your-own Cigarettes, and Attitudes towards Incoming Regulations

(2017) Alessandra Lugo et al.   TUMORI

NOX isoforms in the development of abdominal aortic aneurysm

(2017) Kin Lung Siu et al.   Redox Biology

Smoking in Italy in 2015-2016: Prevalence, Trends, Roll-your-own Cigarettes, and Attitudes towards Incoming Regulations

(2017) Alessandra Lugo et al.   TUMORI JOURNAL

Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO

(2015) Qiang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome

(2014) J.-Y. Youn et al.   DIABETES

The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

(2012) J. Y. Youn et al.   DIABETOLOGIA

An Ezrin/Calpain/PI3K/AMPK/eNOS s1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production

(2008) Ji-Youn Youn et al.   CIRCULATION RESEARCH