Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics
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Title
Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics
Authors
Keywords
NADPH oxidase (NOX), NOX isoform 4 (NOX4), Reactive oxygen species (ROS), eNOS uncoupling/recoupling, Thoracic aortic aneurysm (TAA), Marfan syndrome (MFS), Abdominal aortic aneurysm (AAA), Folic acid (FA), Transforming growth factor–β (TGFβ), Tetrahydrobiopterin (H, 4, B), Dihydrofolate reductase (DHFR), Nitric oxide (NO), GTP cyclohydrolase 1 (GTPCHI)
Journal
Redox Biology
Volume 38, Issue -, Pages 101757
Publisher
Elsevier BV
Online
2020-10-13
DOI
10.1016/j.redox.2020.101757
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