Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

Ferroptosis-Related Flavoproteins: Their Function and Stability

(2021) R. Martin Vabulas   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The diverse functionality of NQO1 and its roles in redox control

(2021) David Ross et al.   Redox Biology

Flavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency

(2020) Adrían Martínez-Limón et al.   Cell Death & Disease

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

(2020) Ernesto Anoz-Carbonell et al.   Antioxidants

A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation

(2020) David Siegel et al.   Redox Biology

Moving Through Barriers in Science and Life

(2019) Judith P. Klinman   Annual Review of Biochemistry

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

(2019) Sarah K. Beaver et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Negative cooperativity in NAD(P)H quinone oxidoreductase 1 (NQO1)

(2019) Clare F Megarity et al.   CHEMBIOCHEM

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

(2019) Clare F. Megarity et al.   BIOSCIENCE REPORTS

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

(2019) Vankova et al.   Biomolecules

Biophysical and functional perturbation analyses at cancer-associated P187 and K240 sites of the multifunctional NADP(H):quinone oxidoreductase 1

(2018) Angel L. Pey   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability

(2018) Encarnación Medina-Carmona et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1)

(2017) Wolf-Dieter Lienhart et al.   FEBS Journal

A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R

(2017) Inés G. Muñoz et al.   FEBS LETTERS

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

(2017) Encarnación Medina-Carmona et al.   HUMAN MOLECULAR GENETICS

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

(2017) Encarnación Medina-Carmona et al.   Scientific Reports

Peroxisome protein import: a complex journey

(2016) A. Baker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

On the link between conformational changes, ligand binding and heat capacity

(2016) S. Vega et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Recognition of enzymes lacking bound cofactor by protein quality control

(2016) Adrián Martínez-Limón et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

(2016) Encarnación Medina-Carmona et al.   Scientific Reports

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

Dynamics of the active site architecture in plant-type ferredoxin-NADP+ reductases catalytic complexes

(2014) Ana Sánchez-Azqueta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

(2014) Angel L. Pey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Components and regulation of nuclear transport processes

(2014) Bastien Cautain et al.   FEBS Journal

Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase1

(2014) Wolf-Dieter Lienhart et al.   FEBS Journal

The human flavoproteome

(2013) Wolf-Dieter Lienhart et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis

(2013) B Lajin et al.   BRITISH JOURNAL OF CANCER

Minor Activities and Transition State Properties of the Human Steroid Hydroxylases Cytochromes P450c17 and P450c21, from Reactions Observed with Deuterium-Labeled Substrates

(2012) Francis K. Yoshimoto et al.   BIOCHEMISTRY

Predictions from an Ising-like Statistical Mechanical Model on the Dynamic and Thermodynamic Effects of Protein Surface Electrostatics

(2012) Athi N. Naganathan   Journal of Chemical Theory and Computation

Update 1 of: Tunneling and Dynamics in Enzymatic Hydride Transfer

(2010) Zachary D. Nagel et al.   CHEMICAL REVIEWS

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A two-domain structure for the two subunits of NAD(P)H:quinone acceptor oxidoreductase

(2010) Shiuan Chen et al.   PROTEIN SCIENCE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA