Paeonol promotes Opa1-mediated mitochondrial fusion via activating the CK2α-Stat3 pathway in diabetic cardiomyopathy

Design and synthesis of novel 2-arylbenzimidazoles as selective mutant isocitrate dehydrogenase 2 R140Q inhibitors

(2020) Zhenyu Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nanosphere Loaded with Curcumin Inhibits the Gastrointestinal Cell Death Signaling Pathway Induced by the Foodborne Pathogen Vibrio vulnificus

(2020) Ji-Yun Kim et al.   Cells

The role of mitochondrial dynamics in cardiovascular diseases

(2020) Maurizio Forte et al.   BRITISH JOURNAL OF PHARMACOLOGY

The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

(2020) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids

(2020) Fatin Farhana Jubaidi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt

(2019) Futian Xu et al.   Frontiers in Pharmacology

Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells

(2019) Rui-Qi Chang et al.   Cell Death & Disease

Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

(2019) Dorian A. Rosen et al.   Science Translational Medicine

Post-Translational Modifications of Mitochondrial Fission and Fusion Proteins in Cardiac Physiology and Pathophysiology

(2019) Stephane M Adaniya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier

(2019) Asmita Gyawali et al.   Biomolecules & Therapeutics

Three Polymethoxyflavones Purified from Ougan (Citrus reticulata Cv. Suavissima) Inhibited LPS-Induced NO Elevation in the Neuroglia BV-2 Cell Line via the JAK2/STAT3 Pathway

(2019) Yue Wang et al.   Nutrients

Paeonol: pharmacological effects and mechanisms of action

(2019) Liang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Paeonol prevents IL-1β-induced inflammatory response and degradation of type II collagen in human primary chondrocytes

(2019) Qianjun Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Mitochondrial fusion mediated by fusion promotion and fission inhibition directs adult mouse heart function toward a different direction

(2019) Yuan Qin et al.   FASEB JOURNAL

Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1‐dependent way

(2019) Mingge Ding et al.   Acta Physiologica

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

(2018) Maura Knapp et al.   ACTA PHARMACOLOGICA SINICA

NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α

(2018) Hao Zhou et al.   BASIC RESEARCH IN CARDIOLOGY

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

(2018) Hao Zhou et al.   CELL DEATH AND DIFFERENTIATION

PGC-1: The Energetic Regulator in Cardiac Metabolism

(2018) Wencheng Di et al.   CURRENT ISSUES IN MOLECULAR BIOLOGY

Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway

(2018) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1

(2018) Lei Zhang et al.   Frontiers in Pharmacology

Intestinal epithelial cell apoptosis due to a hemolytic toxin from Vibrio vulnificus and protection by a 36 kDa glycoprotein from Rhus verniciflua Stokes

(2018) Young-Min Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression

(2017) Ning Liu et al.   INFLAMMATION RESEARCH

Dynamin-related protein 1-mediated mitochondrial fission contributes to post-traumatic cardiac dysfunction in rats and the protective effect of melatonin

(2017) Mingge Ding et al.   JOURNAL OF PINEAL RESEARCH

Protein kinase CK2 regulates redox homeostasis through NF-κB and Bcl-xL in cardiomyoblasts

(2017) Susanne Schaefer et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial dynamics and cell death in heart failure

(2016) José Marín-García et al.   HEART FAILURE REVIEWS

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

(2016) Verena Leidgens et al.   Oncotarget

Paeonol and danshensu combination attenuates apoptosis in myocardial infarcted rats by inhibiting oxidative stress: Roles of Nrf2/HO-1 and PI3K/Akt pathway

(2016) Hua Li et al.   Scientific Reports

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NF B-Opa-1 Signaling Pathway

(2013) V. Parra et al.   DIABETES

Hypoglycemic and Antioxidant Activities of Paeonol and Its Beneficial Effect on Diabetic Encephalopathy in Streptozotocin-Induced Diabetic Rats

(2013) Jiping Liu et al.   JOURNAL OF MEDICINAL FOOD

Mitochondria in heart failure: the emerging role of mitochondrial dynamics

(2012) José Marín-García et al.   HEART FAILURE REVIEWS

Mitochondrial dysfunction in diabetic cardiomyopathy

(2011) Jennifer G. Duncan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structural and functional determinants of protein kinase CK2α: facts and open questions

(2011) Roberto Battistutta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Paeonol Prevents Excitotoxicity in Rat Pheochromocytoma PC12 Cells via Downregulation of ERK Activation and Inhibition of Apoptosis

(2011) Xuncui Wang et al.   PLANTA MEDICA

Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress

(2010) Lele Ji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Protein Kinase CK2 in Health and Disease

(2009) R. Battistutta   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxytocin Increases Glucose Uptake in Neonatal Rat Cardiomyocytes

(2009) Maria Florian et al.   ENDOCRINOLOGY

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

Prognostic impact of diabetes mellitus in patients with heart failure and preserved ejection fraction: a prospective five-year study

(2008) C Tribouilloy et al.   HEART

Down-regulation of Catalase and Oxidative Modification of Protein Kinase CK2 Lead to the Failure of Apoptosis Repressor with Caspase Recruitment Domain to Inhibit Cardiomyocyte Hypertrophy

(2008) Iram Murtaza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paeonol and Paeoniflorin, the Main Active Principles of Paeonia albiflora, Protect the Heart from Myocardial Ischemia/Reperfusion Injury in Rats

(2008) Irina Nizamutdinova et al.   PLANTA MEDICA

Paeonol Attenuates High-Fat-Diet-Induced Atherosclerosis in Rabbits by Anti-Inflammatory Activity

(2008) Houkai Li et al.   PLANTA MEDICA