Article
Biochemistry & Molecular Biology
Min Jiang, Changyin Fang, Yongping Ma
Summary: This study aimed to determine the correlation between pyroptosis-related lncRNAs and gastric cancer prognoses. A predictive signature including six pyroptosis-related lncRNAs was established and confirmed to possess good predictive performance. High-risk gastric cancer patients were found to benefit from the combination of immunotherapy and chemotherapy. These findings highlight the potential of pyroptosis-related lncRNAs as novel biomarkers for the prognosis and treatment of gastric cancer.
Article
Cell Biology
Yaofen Tu, Xiaodi Ding, Zujie Mao
Summary: In this study, we comprehensively analyzed the prognostic value and immune infiltrates of pyroptosis-related genes in bladder cancer. The results showed that 14 genes were upregulated or downregulated in bladder cancer, and a prognostic signature was constructed for predicting survival outcomes. Additionally, a regulatory axis involving lncRNA SNHG14/miR-20a-5p/CASP8 was identified in bladder cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Peng Wang, Zhiqiang Wang, Liping Zhu, Yilan Sun, Leandro Castellano, Justin Stebbing, Zhentao Yu, Ling Peng
Summary: Through bioinformatics analysis, we identified a novel pyroptosis-related lncRNA signature that has prognostic value for bladder cancer patients and may serve as potential targets in cancer immunology.
Article
Oncology
Yuying Zhang, Baoyi Zhu, Minghui He, Yi Cai, Xiaoling Ying, Chonghe Jiang, Weidong Ji, Jianwen Zeng
Summary: This study identified m6A-related lncRNAs using TCGA and IMvigor210 datasets, establishing a 12 m6A-related lncRNA prognostic score (m6A-LRS) with clinical and immune relevance in bladder cancer. High m6A-LRS tumors showed poorer prognosis and immune response, and enrichment analysis revealed associations with tumor-related processes, oncogenic signaling, and tumor hallmarks.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Meng-Jie Zhang, Yuan-Yuan Wang, Lin-Lin Han, Xin-Yang Liu, Yun-Yun Xie, Zhigang Xu, Zhi-Jun Sun
Summary: Cancer immunotherapy has the potential to revolutionize malignant tumor treatment, but low immune response rates limit its effectiveness. This review discusses the design strategies and mechanisms of biomaterials to induce pyroptosis and their significance in tumor immunotherapy. Tailored biomaterials can elicit pyroptosis, fueling a strong antitumor immune response.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Oncology
Huizhong Wang, Ruonan Shao, Shujing Lu, Shenrui Bai, Bibo Fu, Renchun Lai, Yue Lu
Summary: Pyroptosis has the potential to be a novel cancer therapeutic target in multiple myeloma (MM) patients. Using a gene expression database and validation cohorts, we found that high-risk patients have significantly lower overall survival compared to low-risk patients. Functional enrichment and immune infiltration analyses demonstrated the correlation between immune status and risk scores. Additionally, the use of a pyroptosis inhibitor suppressed MM cell proliferation and progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Aibin Liu, Lin Shen, Na Li, Liangfang Shen, Zhanzhan Li
Summary: Through comprehensive analysis, it was found that pyroptosis is aberrantly expressed in different types of cancer, attributed to CAN frequency and differences in DNA methylation levels. A pyroptosis level model was established, revealing a dual role of pyroptosis in cancers, with different levels across multiple cancers significantly associated with clinical prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Xin Gao, Jianping Cai
Summary: This study comprehensively analyzed the molecular characteristics of pyroptosis-related (PR) genes and long non-coding RNAs (lncRNAs) in bladder cancer (BLCA). The identified eight-PR-lncRNA signature may play a crucial role in tumor immunity and have the potential to predict the prognosis of BLCA patients. This study provides a theoretical basis for further investigation into the relationship between prognosis and the tumor immune microenvironment (TIME).
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Mingyi Yang, Haishi Zheng, Yani Su, Ke Xu, Qiling Yuan, Yongsong Cai, Yirixiati Aihaiti, Peng Xu
Summary: This study identified pyroptosis-related biomarkers associated with the prognosis and immune microenvironment of osteosarcoma (OS), and established prognostic and risk score models to evaluate the risk of OS patients. The findings suggest that PRLncs-score is closely associated with the prognosis and immune microenvironment characteristics of OS patients.
Article
Genetics & Heredity
Kai Zhao, Xiangyu Li, Yuanxin Shi, Yun Lu, Peng Qiu, Zhengdong Deng, Wei Yao, Jianming Wang
Summary: This study comprehensively analyzed the potential values of pyroptosis-related lncRNAs in pancreatic adenocarcinoma (PAAD). A risk signature based on pyroptosis-related lncRNAs was established and validated, showing clinical significance and connection with the tumor immune microenvironment (TIME). The results suggest that this risk signature could be used for prognosis prediction and guide immunotherapeutic strategies in PAAD patients.
FRONTIERS IN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Yao Xiao, Tian Zhang, Xianbin Ma, Qi-Chao Yang, Lei-Lei Yang, Shao-Chen Yang, Mengyun Liang, Zhigang Xu, Zhi-Jun Sun
Summary: The absence of tumor antigens poses a challenge in ICB therapy, but inducing tumor-specific pyroptosis while reducing injury in normal tissues is urgently needed. A ROS/GSH dual-responsive nano-prodrug called MCPP with high PTX and P18 loading is designed to selectively induce pyroptosis in tumor cells. Chemo-photodynamic therapy and controlled-release PTX synergistically induce pyroptosis, releasing DAMPs and enhancing ICB efficiency, suggesting a smart strategy to trigger pyroptosis and augment ICB efficiency.
Article
Cell Biology
Shuai Ma, Hongtao Zhao, Fang Wang, Lulu Peng, Heng Zhang, Zaibin Wang, Fan Jiang, Dongtao Zhang, Menglei Yin, Shupeng Li, Jiaming Huang, Zhan Liu, Shengzhong Tao
Summary: This study aimed to identify pyroptosis-related lncRNAs (PRLs) using bioinformatic algorithm and validate them in human glioma tissues through PCR techniques. The results showed that the molecular subtypes categorized by PRLs were not distinct from previously published subtypes of glioma. However, the immune and mutation landscapes were significantly different. Furthermore, analysis of patient sensitivity to 30 chemotherapeutic agents identified 22 potential therapeutic agents for low-risk patients.
Article
Cell Biology
Jiawei Rao, Wen Li, Chuangqi Chen
Summary: The study identified two PYG-mediated molecular subtypes in colon cancer, affecting the composition of the tumor microenvironment; the infiltration of immune cells was significantly different between the low and high PY-score groups; patients in the low PY-score group showed better survival advantage and were more sensitive to certain treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Lei Ren, Xu Yang, Jinwen Liu, Weifeng Wang, Zixiong Liu, Qingyuan Lin, Bin Huang, Jincheng Pan, Xiaopeng Mao
Summary: A prognostic model based on m7G-related lncRNAs was developed in this study, which has predictive value in prognosis and anti-cancer treatment sensitivity of bladder cancer. The model accurately predicts the prognosis of bladder cancer patients and provides robust directions for clinicians to develop better individualized and precise treatment strategies.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Xuan Zhou, Liangyu Yao, Xiang Zhou, Rong Cong, Jiaochen Luan, Xiyi Wei, Xu Zhang, Ninghong Song
Summary: This study presents a novel risk model for evaluating ccRCC and identifies potential pyroptosis-related therapeutic targets in the clinic.
FRONTIERS IN ONCOLOGY
(2022)
Article
Andrology
Zicheng Xu, Xiao Li, Feng Qi, Xin Hu, Yuxiao Zheng, Hongzhou Cai, Ting Xu, Bin Yu, Qing Zou
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2019)
Article
Medicine, Research & Experimental
Hongzhou Cai, Xuejian Yang, Yang Gao, Zicheng Xu, Bin Yu, Ting Xu, Xiao Li, Weizhang Xu, Xinwei Wang, Lixin Hua
MOLECULAR THERAPY-NUCLEIC ACIDS
(2019)
Review
Environmental Sciences
Zhongyuan Wang, Tongtong Zhang, Jiajin Wu, Xiyi Wei, Aiming Xu, Shangqian Wang, Zengjun Wang
Summary: The study found that exposure to PFOA leads to damage in the male rodent reproductive system, characterized by abnormal hormone levels, disrupted development of reproductive organs, and abnormal sperm parameters. However, the mechanisms by which PFOA induces these changes have not been identified and require further research.
Article
Andrology
Ye Tian, Jiajin Wu, Jie Yang, Jianxin Xue, Muaz Peerbocus, Erfu Xie, Zengjun Wang
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Article
Environmental Sciences
Tongtong Zhang, Jiajin Wu, Xu Zhang, Xiang Zhou, Shangqian Wang, Zengjun Wang
Summary: The prediction of harmful effects through pharmacological technology and omics database facilitates the research on health hazards of environmental pollutants. In this study, the potential prostatic cancer-promoting effect of dibutyl phthalate was predicted and verified through cell experiments and gene expression analysis. The findings suggest that low concentrations of dibutyl phthalate may have adverse effects on prostate cancer patients.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Tongtong Zhang, Xiang Zhou, Xu Zhang, Xiaohan Ren, Jiajin Wu, Zhongyuan Wang, Shangqian Wang, Zengjun Wang
Summary: Phthalate, an environmental endocrine disruptor, has been found to cause direct and intergenerational male reproductive damage. This study explored the effects of prenatal exposure to DBP on testicular injury and offspring gut microbiota, revealing a connection between gut dysbiosis and testicular damage in the offspring. Understanding the role of gut microbiota in reproductive function is crucial, and further research is needed to investigate the link between environmental pollution and human health.
Article
Medicine, Research & Experimental
Yankang Cui, Chenkui Miao, Shouyong Liu, Jingyuan Tang, Jing Zhang, Hengtao Bu, Yuhao Wang, Chao Liang, Meiling Bao, Chao Hou, Jiajin Wu, Xiaochao Chen, Xiang Zhang, Zengjun Wang, Bianjiang Liu
Summary: The study showed that CLU acts as a tumor suppressor to inhibit the metastasis of testicular seminoma by regulating cell proliferation and migration abilities, as well as influencing the EMT process.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Endocrinology & Metabolism
Tongtong Zhang, Xiang Zhou, Xiaohan Ren, Xu Zhang, Jiajin Wu, Shangqian Wang, Zengjun Wang
Summary: TCDD has negative effects on the male reproductive system of rodents, including reducing testis weight, sperm count, and blood testosterone concentration. The research suggests that TCDD may cause damage to the male reproductive system through direct or indirect exposure. Further research on human-related effects of TCDD is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Haofeng Liu, Qiu Xue, Hongzhou Cai, Xiaohui Jiang, Guangxin Cao, Tie Chen, Yuan Chen, Ding Wang
Summary: This study reveals the significance and mechanism of RUNX3-mediated circDYRK1A in suppressing glutamine metabolism in gastric cancer (GC) via the miR-889-3p/FBXO4 axis, which leads to the attenuation of malignant phenotypes in GC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Ting Xu, Weizhang Xu, Yuxiao Zheng, Xiao Li, Hongzhou Cai, Zicheng Xu, Qing Zou, Bin Yu
Summary: This study found that the FARG signature based on a comprehensive FGFR3 alteration-related transcriptomic profile can effectively predict the prognosis of bladder cancer patients and is also associated with treatment responses to immunotherapy and chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yuqiu Ge, Bin Xu, Hongzhou Cai, Wentao Jing, Qiong Ouyang, Qinbo Yuan, Xu Li, Yuanming Fan, Yang Shen, Qianqian Shi, Qiangdong Wang, Li Cui, Xiaojian Yin, Gaoxiang Ma
Summary: In this study, ORM2 was identified as a complementary biomarker to PSA in distinguishing between PCa and BPH, showing superior predictive accuracy compared to PSA alone.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Hongzhou Cai, Haifei Xu, Hongcheng Lu, Weizhang Xu, Haofeng Liu, Xinwei Wang, Guoren Zhou, Xuejian Yang
Summary: In this study, it was found that SNHG1 was highly expressed in bladder cancer and was associated with poor clinical outcomes. It was verified that SNHG1 promoted tumor proliferation and suppressed apoptosis. The results indicated that SNHG1 acted as a competitive endogenous RNA to decrease the expression of MDM2 by sponging microRNA-9-3p, thus inducing the ubiquitination and degradation of PPAR-gamma.
Review
Oncology
Yun Hu, Yan Li, Zhangcheng Yao, Fenglin Huang, Hongzhou Cai, Hanyuan Liu, Xiaoyi Zhang, Junying Zhang
Summary: Breast cancer is one of the most common and threatening cancers in women, and the combination therapy of immunotherapy with other technologies has shown positive effects in treating breast cancer. This review aims to study the value of immunotherapy in breast cancer treatment, with a focus on triple-negative breast cancer (TNBC). The article introduces tumor markers related to immunotherapy for breast cancer and discusses the clinical effects of different combinations of immunotherapy with chemotherapy, molecular targeted therapy, radiotherapy, and nanotechnology.