Article
Immunology
Klaus Berek, Angelika Bauer, Dagmar Rudzki, Michael Auer, Robert Barket, Anne Zinganell, Magdalena Lerch, Livia Hofer, Astrid Grams, Paulina Poskaite, Sebastian Wurth, Thomas Berger, Franziska Di Pauli, Florian Deisenhammer, Harald Hegen, Markus Reindl
Summary: This study investigated the distribution of 65 different cytokines, chemokines, and related molecules in the cerebrospinal fluid (CSF) and serum of newly diagnosed people with multiple sclerosis (pwMS). The results showed that 29 cytokines and chemokines were significantly elevated in the CSF, while 15 were elevated in the serum. Additionally, associations were found between 34 analytes and sex, age, CSF, MRI parameters, and disease progression. These findings contribute to a better understanding of the pathophysiology of multiple sclerosis and its association with disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Shinji Ashida, Takayuki Kondo, Chihiro Fujii, Mio Hamatani, Toshiki Mizuno, Hirofumi Ochi
Summary: This study found that the inflammatory profile in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is associated with magnetic resonance imaging (MRI) findings. This suggests that combined CSF and MRI analysis may help identify different MS phenotypes related to the heterogeneity of underlying immune processes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marlos Aureliano Dias de Sousa, Chamberttan Souza Desiderio, Jonatas da Silva Catarino, Rafael Obata Trevisan, Djalma Alexandre Alves da Silva, Vinicius Ferreira Resende Rocha, Weslley Guimaraes Bovi, Rodolfo Pessato Timoteo, Renata Cristina Franzon Bonatti, Alex Eduardo da Silva, Alfredo Leboreiro Fernandez, Helioswilton Sales-Campos, Virmondes Rodrigues Junior, Marcos Vinicius da Silva, Carlo Jose Freire de Oliveira
Summary: The immune response in multiple sclerosis involves CD4(+) T cells that produce cytokines and chemokines. Changes in certain cytokines and chemokines, along with the presence of double positive lymphocytes, can help better understand the clinical forms and progression of the disease.
Article
Neurosciences
Si-Si Jiang, Yi-Ling Wang, Qiu-Han Xu, Lu-Yan Gu, Rui-Qing Kang, Wen-Yi Yang, Bao-Rong Zhang, Jun Tian, Jia-Li Pu
Summary: Peripheral immune cells, specifically CD8(+) T cells and NK cells, in patients with Parkinson's disease (PD) exhibit disrupted secretion of pro-inflammatory cytokines and chemokines, such as TNF-& alpha;, IL-8, IL-1 & beta;, and CCL17. These cytokines and cell clusters are associated with clinical symptoms, including cognitive impairment and motor symptoms. The levels of intracellular TNF-& alpha; in CD8(+) T cells and NK cells are negatively correlated with cognitive assessment scores and positively correlated with the severity of motor symptoms. This study provides important insights into the role of peripheral immune cells in PD pathogenesis.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Andrew R. Pachner
Summary: There have been significant advancements in the field of neuroimmunology of multiple sclerosis in the past decades. These advancements have improved diagnosis and therapy. However, there are still many controversies and gaps in understanding due to the complexity of the disease.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mark M. Melamud, Evgeny A. Ermakov, Anastasiia S. Boiko, Daria A. Kamaeva, Alexey E. Sizikov, Svetlana A. Ivanova, Natalia M. Baulina, Olga O. Favorova, Georgy A. Nevinsky, Valentina N. Buneva
Summary: The study revealed that 11 cytokines were increased in the cytokine profile of systemic lupus erythematosus patients, while 10 cytokines were significantly decreased in multiple sclerosis patients. These changes were associated with dysregulation of interleukins, TNF superfamily members, and chemokines in SLE, and abnormal levels of growth factors and chemokines in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jessica Rauch, Johanna Friederike Steffen, Birgit Muntau, Jana Gisbrecht, Kirsten Poertner, Christiane Herden, Hans Helmut Niller, Markus Bauswein, Dennis Rubbenstroth, Ute Mehlhoop, Petra Allartz, Dennis Tappe
Summary: Human Borna disease virus 1 (BoDV-1) encephalitis is characterized by an increasing immune activation, pro-inflammatory pattern and dysbalanced growth factor levels. The presence of inflammatory biomarkers and chemokines attracts immune cells and contributes to the inflammation and tissue damage. This dysregulated and pro-inflammatory state may play a crucial role in the fatal outcome of human BoDV-1 encephalitis and could be a potential target for treatment.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Neurosciences
Matteo Lucchini, Valeria De Arcangelis, Geny Piro, Viviana Nociti, Assunta Bianco, Chiara De Fino, Gabriele Di Sante, Francesco Ria, Paolo Calabresi, Massimiliano Mirabella
Summary: This study assessed the concentration of several biomarkers in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients and investigated their diagnostic and prognostic significance. The results showed that higher CSF levels of CHI3L1 and CXCL13 were associated with a higher risk of relapse, MRI activity, and overall disease activity in MS patients. These findings suggest that CSF CHI3L1 and CXCL13 levels can serve as good prognostic biomarkers in MS patients and aid in treatment decisions. The study also found differences in CSF BAFF and APRIL levels between different phases of MS, indicating the modulation of B-cells pathways vary in different disease stages.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Endocrinology & Metabolism
Soudeh Ghafouri-Fard, Kasra Honarmand, Mohammad Taheri
Summary: Multiple sclerosis (MS) is considered to be a chronic inflammatory disorder of the central nervous system caused by abnormal immune responses. Chemokines play an important role in the pathogenesis of MS, with several members of this family being dysregulated in MS patients' peripheral blood, cerebrospinal fluid, or CNS lesions. Studies in animal models have shown the critical roles of chemokines in the pathophysiology of MS.
METABOLIC BRAIN DISEASE
(2021)
Article
Clinical Neurology
Keith Carolus, Tom A. Fuchs, Niels Bergsland, Deepa Ramasamy, Hoan Tran, Tomas Uher, Dana Horakova, Manuela Vaneckova, Eva Havrdova, Ralph H. B. Benedict, Robert Zivadinov, Michael G. Dwyer
Summary: White matter tract disruptions connected to the thalamus impact thalamic atrophy 1 year later, while disruptions connected to the deep gray matter impact DGM atrophy in the following year. Concurrent or preceding white matter tract disruptions within 2-4 years do not have a significant association with the subsequent atrophy of the thalamus or deep gray matter.
JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Mieke Metzemaekers, Seppe Cambier, Marfa Blanter, Jennifer Vandooren, Ana Carolina de Carvalho, Bert Malengier-Devlies, Lore Vanderbeke, Cato Jacobs, Sofie Coenen, Erik Martens, Noemie Portner, Lotte Vanbrabant, Pierre Van Mol, Yannick Van Herck, Nathalie Van Aerde, Greet Hermans, Jan Gunst, Alexandre Borin, Bruna Toledo N. Pereira, Arilson Bernardo dos S. P. Gomes, Stefanie Primon Muraro, Gabriela Fabiano de Souza, Alessandro S. Farias, Jose Luiz Proenca-Modena, Marco Aurelio R. Vinolo, Contagious Consortium, Pedro Elias Marques, Carine Wouters, Els Wauters, Sofie Struyf, Patrick Matthys, Ghislain Opdenakker, Rafael Elias Marques, Joost Wauters, Mieke Gouwy, Paul Proost
Summary: Our study explores the characteristics of neutrophils in severe COVID-19 patients, showing increased plasma concentrations of G-CSF and CXCL8 upon ICU admission, indicating emergency myelopoiesis. COVID-19 neutrophils were hyper-responsive to CXCL8 and CXCL12, suggesting an increased activation state in the circulation.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Sara Guerrero, Esther Sanchez-Tirado, Lourdes Agui, Araceli Gonzalez-Cortes, Paloma Yanez-Sedeno, Jose M. Pingarron
Summary: This paper reports an electrochemical immunoplatform for rapid detection of CCL5 chemokine in multiple sclerosis patients, showing excellent analytical performance and low detection limit.
Article
Clinical Neurology
Maria Di Gregorio, Valentina Liliana Adriana Torri Clerici, Giuseppe Fenu, Lorenzo Gaetani, Antonio Gallo, Paola Cavalla, Paolo Ragonese, Pietro Annovazzi, Alberto Gajofatto, Luca Prosperini, Doriana Landi, Carolina Gabri Nicoletti, Caterina Di Carmine, Rocco Totaro, Viviana Nociti, Chiara De Fino, Diana Ferraro, Valentina Tomassini, Carla Tortorella, Isabella Righini, Maria Pia Amato, Alessia Manni, Damiano Paolicelli, Pietro Iaffaldano, Roberta Lanzillo, Marcello Moccia, Fabio Buttari, Roberta Fantozzi, Raffaella Cerqua, Sara Zagaglia, Deborah Farina, Giovanna De Luca, Maria Chiara Buscarinu, Federica Pinardi, Eleonora Cocco, Claudio Gasperini, Claudio Marcello Solaro, Massimiliano Di Filippo
Summary: The study found that tumefactive multiple sclerosis (TuMS) primarily affects women with a young onset age, and presents with unique disease characteristics. Some patients require multiple acute-phase treatments, while those with certain risk factors may experience disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Goetz, Jun-ichi Kira
Summary: By knocking out the Cx43 gene in astroglia, EAE clinical symptoms can be alleviated, reducing inflammation cell infiltration and demyelination in the spinal cord, meanwhile promoting anti-inflammatory gene expression and inhibiting proinflammatory gene expression.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Biochemistry & Molecular Biology
Gholamhossein Hassanshahi, Mohammad Amin Roohi, Seyed-Alireza Esmaeili, Hossein Pourghadamyari, Reza Nosratabadi
Summary: Multiple sclerosis (MS) is a chronic immune-mediated disease with no known treatment yet. Mesenchymal stem cells (MSCs) show promise in MS treatment by their ability to migrate and home into the CNS. The chemokine/chemokine receptor axes play a pivotal role in MSC trafficking and their targeted tropism to the CNS in MS patients.
Article
Immunology
Jing Sun, Haijun Li, Yangjie Jin, Jiaheng Yu, Shiyin Mao, Kuan-Pin Su, Zongxin Ling, Jiaming Liu
Summary: The study suggests that the probiotic Clostridium butyricum (Cb) has neuroprotective effects on Parkinson's disease (PD) by improving abnormal gut microbiota-gut-brain axis. This intervention could potentially reverse motor deficits, dopaminergic neuron loss, synaptic dysfunction, and microglia activation in PD, providing a new insight into treating PD through gut microbiota modulation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Food Science & Technology
Zongxin Ling, Xia Liu, Yiwen Cheng, Xiumei Yan, Shaochang Wu
Summary: The altered assembly, structure and dynamics of the gut microbiota actively participate in the aging process, affecting healthy aging and age-associated diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Hua Zha, Fengping Liu, Zongxin Ling, Kevin Chang, Jiezuan Yang, Lanjuan Li
Summary: This study investigated the genitourinary microbiome profiles in patients with Type 2 diabetes mellitus (T2DM) through bioinformatic and statistical analyses. Different clusters of microbiome profiles were identified, each driven by distinct bacteria and metabolites, with implications for the diagnosis and management of genitourinary dysbiosis in T2DM patients.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Shengyi Han, Yanmeng Lu, Jiaojiao Xie, Yiqiu Fei, Guiwen Zheng, Ziyuan Wang, Jie Liu, Longxian Lv, Zongxin Ling, Bjorn Berglund, Mingfei Yao, Lanjuan Li
Summary: Orally administered probiotics face challenges in the mouth, stomach, intestine, and colon, primarily due to the reduction of viable bacteria and colonization resistance by commensal bacteria. Factors affecting probiotic viability and their mucoadhesive properties, including mucosadhesion-related proteins on the cell surface, are discussed in this review.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Cell Biology
Zongxin Ling, Manlian Zhu, Xiumei Yan, Yiwen Cheng, Li Shao, Xia Liu, Ruilai Jiang, Shaochang Wu
Summary: The study found that gut dysbiosis in Chinese Alzheimer's disease (AD) patients results in a decrease in bacterial diversity, a reduction in butyrate-producing genera positively correlated with cognitive scores, and an increase in lactate-producing genera inversely correlated with these indicators. This shift in gut dysbiosis contributes to immune disturbances in the host, serving as potential non-invasive biomarkers for distinguishing AD patients from controls. Additionally, altered functional modules in the gut microbiota of AD patients may produce immunomodulatory metabolites.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zongxin Ling, Manlian Zhu, Xia Liu, Li Shao, Yiwen Cheng, Xiumei Yan, Ruilai Jiang, Shaochang Wu
Summary: This study found altered taxonomic composition of the fecal fungal microbiota in AD patients, with specific fungi enriched or decreased. Key differential fungi such as Candida tropicalis and Schizophyllum commune were positively correlated with certain immune response markers, while Rhodotorula mucilaginosa showed negative correlation with TNF-alpha level. The analysis revealed potential implications for the etiopathogenesis of AD and improved diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Food Science & Technology
Yiwen Cheng, Jiaming Liu, Zongxin Ling
Summary: Psychobiotics, live microorganisms with mental health benefits, are emerging as novel therapeutic options for psychiatric disorders. Studies have identified potential psychobiotic strains, particularly SCFAs-producing bacteria like Lactobacillus, Bifidobacterium, and Clostridium, which play specific roles in psychiatric disorders. These bacteria may modulate neurological processes via the microbiota-gut-brain axis, suggesting their potential as novel psychobiotics.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Microbiology
Jinpu Yang, Xinxin Zhou, Xiaosun Liu, Zongxin Ling, Feng Ji
Summary: The gastric microbiome plays a critical role in maintaining homeostasis and promoting gastric carcinogenesis, with both H. pylori and non-H. pylori bacteria contributing to the development of gastric cancer. Understanding the contribution of the gastric microbiome to GC can lead to improvements in prevention, diagnosis, and treatment.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Jian Wu, Mariza Bortolanza, Guanghua Zhai, Anquan Shang, Zongxin Ling, Bin Jiang, Xiaochen Shen, Yiwen Yao, Jiong Yu, Lanjuan Li, Hongcui Cao
Summary: The study found no significant difference in bacterial diversity between patients with acute hepatitis E and healthy controls, but Proteobacteria, Gammaproteobacteria, and Enterobacteriaceae were more abundant in AHE patients. Functional prediction analysis revealed that ribosome, purine metabolism, and two-component system were the top three pathways affected by HEV infection. Furthermore, higher levels of interferon-gamma were associated with increased abundance of certain bacterial taxa in AHE patients, and Gammaproteobacteria abundance was positively correlated with liver enzyme levels.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Yao-Hua Shen, Fan Yang, Li-Dan Jin, Yu-Jia Qian, Li Xing, Ya-Li Huang, Su-Feng Lin, Fei Xiao
Summary: The prophylactic infusion of phenylephrine to prevent post-spinal hypotension during cesarean delivery was associated with a higher dose of oxytocin, potentially leading to an increased need for secondary uterotonic agents. However, further studies are needed to confirm these findings and understand the clinical implications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Zeng, Xujun Zhang, Tianxin Xiang, Zongxin Ling, Chenhong Lin, Hongyan Diao
Summary: This study comprehensively analyzed the expression and oncogenic features of SPP1 in cancers using the TCGA database, revealing that SPP1 is highly expressed in most cancers and is associated with tumor prognosis, immune invasion, tumor microenvironment, and immunotherapy. Functional analysis identified the terms and pathways related to SPP1. Further experiments validated the oncogenic features of SPP1.
Review
Oncology
Jinpu Yang, Xia Liu, Yiwen Cheng, Jingchen Zhang, Feng Ji, Zongxin Ling
Summary: Gastric cancer is the fifth most common neoplasm and the third most deadly cancer worldwide. Helicobacter pylori infection is the major cause of gastric carcinogenesis and triggers immune responses in the host. Plasmacytoid dendritic cells (pDCs), as important components of the tumor immune microenvironment, have been gaining attention for their potential roles in immunosuppression. Recent studies have shown that pDCs play vital roles in the development of immunosuppression in gastric cancer. Understanding the contribution of pDCs to the development and progression of gastric cancer may lead to improved cancer therapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ruiqi Tang, Rongrong Liu, Hua Zha, Yiwen Cheng, Zongxin Ling, Lanjuan Li
Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern that can result in liver disease and cancer. The interaction between gut microbiota and the host epigenome plays a significant role in the development of NAFLD. Gut microbiota-derived factors, such as lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs), can influence the DNA methylation and histone acetylation of genes associated with NAFLD, affecting lipid metabolism and immune homeostasis. Further comprehensive studies are required to understand the molecular mechanisms and signaling pathways underlying this gut microbiota-host crosstalk, potentially leading to improved epigenetic markers and insights into NAFLD pathogenesis.
ENGINEERING IN LIFE SCIENCES
(2023)
Article
Infectious Diseases
Li Shao, Jinlong Fu, Lulu Xie, Guangyong Cai, Yiwen Cheng, Nengneng Zheng, Ping Zeng, Xiumei Yan, Zongxin Ling, Shiwei Ye
Summary: Both schizophrenia and multiple sclerosis have a significant impact on health and society. Recent studies suggest that the gut microbiota, as well as serum cytokines, may play a role in the association between these two diseases.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2023)