A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis

Multiple sclerosis (MS) as a chronic inflammatory disorder of the central nervous system (CNS) is thought to be caused by the abnormal induction of immune responses. Chemokines as molecules that can engage leukocytes into the location of inflammation, actively participate in the pathogenesis of MS. Several members of this family of chemo attractants have been shown to be dysregulated in the peripheral blood, cerebrospinal fluid or CNS lesions of MS patients. Studies in animal models of MS particularly experimental autoimmune encephalomyelitis have indicated the critical roles of chemokines in the pathophysiology of MS. In the current review, we summarize the data regarding the role of CCL2, CCL3, CCL4, CCL11, CCL20, CXCL1, CXCL2, CXCL8, CXCL10, CXCL12 and CXCL13 in the pathogenesis of MS.

Automated summary

Multiple sclerosis (MS) is considered to be a chronic inflammatory disorder of the central nervous system caused by abnormal immune responses. Chemokines play an important role in the pathogenesis of MS, with several members of this family being dysregulated in MS patients' peripheral blood, cerebrospinal fluid, or CNS lesions. Studies in animal models have shown the critical roles of chemokines in the pathophysiology of MS.