Benznidazole Anti-Inflammatory Effects in Murine Cardiomyocytes and Macrophages Are Mediated by Class I PI3Kδ

PD-L1 induces macrophage polarization toward the M2 phenotype via Erk/Akt/mTOR

(2021) Yi Wei et al.   EXPERIMENTAL CELL RESEARCH

The roles of macrophage polarization in the host immune response to sepsis

(2021) Xinsen Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The regulatory effect of acetylation of HMGN2 and H3K27 on pyocyanin‐induced autophagy in macrophages by affecting Ulk1 transcription

(2021) Yu Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A systematic approach to quantitative Western blot analysis

(2020) Lakshmi Pillai-Kastoori et al.   ANALYTICAL BIOCHEMISTRY

Pyridinecarboxylic Acid Derivative Stimulates Pro-Angiogenic Mediators by PI3K/AKT/mTOR and Inhibits Reactive Nitrogen and Oxygen Species and NF-κB Activation Through a PPARγ-Dependent Pathway in T. cruzi-Infected Macrophages

(2020) Federico Nicolás Penas et al.   Frontiers in Immunology

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses

(2020) Anthos Christofides et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease

(2020) Jimena Rada et al.   Frontiers in Immunology

HGF-MET Signaling Shifts M1 Macrophages Toward an M2-Like Phenotype Through PI3K-Mediated Induction of Arginase-1 Expression

(2020) Nao Nishikoba et al.   Frontiers in Immunology

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

(2020) William P. Lafuse et al.   Cells

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

(2019) Marco Orecchioni et al.   Frontiers in Immunology

IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole

(2019) Ágata C. Cevey et al.   Frontiers in Immunology

Tolerance to nifurtimox and benznidazole in adult patients with chronic Chagas’ disease

(2019) Yves Jackson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats

(2018) Yu Long et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial Ca 2+ Influx Contributes to Arrhythmic Risk in Nonischemic Cardiomyopathy

(2018) An Xie et al.   Journal of the American Heart Association

TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses

(2018) Lin Luo et al.   Cell Reports

Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis

(2017) Flavia Lambertucci et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Innate immunomodulation to trypanosomatid parasite infections

(2016) A.L.A. Dos-Santos et al.   EXPERIMENTAL PARASITOLOGY

Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3

(2016) Bing Zhang et al.   MOLECULAR IMMUNOLOGY

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

The trypanocidal benznidazole promotes adaptive response to oxidative injury: Involvement of the nuclear factor-erythroid 2-related factor-2 (Nrf2) and multidrug resistance associated protein 2 (MRP2)

(2016) Juan Pablo Rigalli et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly virulent Trypanosoma cruzi strain

(2016) Ágata Carolina Cevey et al.   International Journal for Parasitology-Drugs and Drug Resistance

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Etiological treatment of Chagas disease patients with benznidazole lead to a sustained pro-inflammatory profile counterbalanced by modulatory events

(2015) A.C. Campi-Azevedo et al.   IMMUNOBIOLOGY

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway

(2014) Wenjuan Bai et al.   CELLULAR SIGNALLING

Anti-inflammatory Actions of Acanthoic Acid-Related Diterpenes Involve Activation of the PI3K p110γ/δ Subunits and Inhibition of NF-κB

(2014) Paqui G. Través et al.   CHEMISTRY & BIOLOGY

Critical Roles of the p110  Subtype of Phosphoinositide 3-Kinase in Lipopolysaccharide-Induced Akt Activation and Negative Regulation of Nitrite Production in RAW 264.7 Cells

(2014) K. Tsukamoto et al.   JOURNAL OF IMMUNOLOGY

Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses

(2014) Emine Sahin et al.   JOURNAL OF IMMUNOLOGY

Chagas Disease Cardiomyopathy: Immunopathology and Genetics

(2014) Edecio Cunha-Neto et al.   MEDIATORS OF INFLAMMATION

Macrophages in homeostatic immune function

(2014) Jonathan Jantsch et al.   Frontiers in Physiology

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Intracellular Function of Interleukin-1 Receptor Antagonist in Ischemic Cardiomyocytes

(2013) Elena Vecile et al.   PLoS One

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K

(2012) Ty Dale Troutman et al.   CELL CYCLE

MT1-MMP regulates the PI3K {middle dot}Mi-2/NuRD-dependent control of macrophage immune function

(2012) R. Shimizu-Hirota et al.   GENES & DEVELOPMENT

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives

(2011) Shane R. Wilkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Alternative activation of macrophages by IL-4 requires SHIP degradation

(2011) Shelley B. Weisser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression

(2011) Marta López-Peláez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of phosphoinositide 3-kinase–Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors

(2011) Mosoka P. Fallah et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols