Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway

Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression

(2016) Rebecca E Graff et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Photopreventive Effect and Mechanism of AZD4547 and Curcumin C3 Complex on UVB-Induced Epidermal Hyperplasia

(2016) Alok R. Khandelwal et al.   Cancer Prevention Research

Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation

(2016) Robert P. Feehan et al.   CELLULAR SIGNALLING

Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention

(2016) Bryan B. Bridgeman et al.   CELLULAR SIGNALLING

Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway

(2016) Marwa Ahmed Abass et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The Effect of Lycopene Preexposure on UV-B-Irradiated Human Keratinocytes

(2016) Andreia Ascenso et al.   Oxidative Medicine and Cellular Longevity

Lycopene acts through inhibition of IκB kinase to suppress NF-κB signaling in human prostate and breast cancer cells

(2016) Emelia A. Assar et al.   TUMOR BIOLOGY

Prevalence and Costs of Skin Cancer Treatment in the U.S., 2002−2006 and 2007−2011

(2015) Gery P. Guy et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model

(2015) Kazim Sahin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lycopene not in pill, nor in natura has photoprotective systemic effect

(2015) Lethicia Sokoloski et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

(2015) Chia-Hung Lin et al.   BMC CANCER

Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors

(2015) Theresa D. Carr et al.   CARCINOGENESIS

Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1

(2015) Xin Tong et al.   Oncotarget

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

(2014) Aifu Lin et al.   CANCER RESEARCH

Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines

(2014) Mikako Takeshima et al.   CANCER SCIENCE

Phosphorylation of Akt at the C-terminal tail triggers Akt Activation

(2014) Pengda Liu et al.   CELL CYCLE

Skin cancer evaluation in transplant patients: a physician opinion survey with recommendations

(2014) Amanda Lloyd et al.   CLINICAL TRANSPLANTATION

Chemoprevention of photocarcinogenesis by lycopene

(2014) Andreia Ascenso et al.   EXPERIMENTAL DERMATOLOGY

Orally Administered Lycopene Attenuates Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats by Modulating Nrf-2/HO-1 and Akt/mTOR Pathways

(2014) Kazim Sahin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Chemomodulatory efficacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcinoma in mice

(2014) Cunsi Shen et al.   Food & Function

Activation of autophagy by globular adiponectin attenuates ethanol-induced apoptosis in HepG2 cells: Involvement of AMPK/FoxO3A axis

(2013) Saroj Nepal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases

(2013) Haidan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Lycopene on Cell Viability, Cell Cycle, and Apoptosis of Human Prostate Cancer and Benign Hyperplastic Cells

(2013) Nathalia da Costa Pereira Soares et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

(2013) J. E. Allen et al.   Science Translational Medicine

Post-translational regulation of FOXO

(2012) Q. Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Regulation of the human TRAIL gene

(2012) Joshua E. Allen et al.   CANCER BIOLOGY & THERAPY

Cancer genetics and genomics of human FOX family genes

(2012) Masuko Katoh et al.   CANCER LETTERS

Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

(2012) T. D. Carr et al.   Cancer Prevention Research

The PKB/FOXO switch in aging and cancer

(2011) David E.A. Kloet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bimodal regulation of FoxO3 by AKT and 14-3-3

(2011) Melissa Dobson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer Chemoprevention by Dietary Phytochemicals: Promises and Pitfalls

(2011) Ramamurthi Vidya Priyadarsini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 MAP kinase plays a functional role in UVB-Induced mouse skin carcinogenesis

(2011) Sally E. Dickinson et al.   MOLECULAR CARCINOGENESIS

New Agents for Prevention of Ultraviolet-Induced Nonmelanoma Skin Cancer

(2011) William L. Camp et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

The Transcription of FOXO Genes Is Stimulated by FOXO3 and Repressed by Growth Factors

(2009) Ahmed Essaghir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted disruption of Bcl-xLin mouse keratinocytes inhibits both UVB- and chemically induced skin carcinogenesis

(2009) Dae Joon Kim et al.   MOLECULAR CARCINOGENESIS

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes

(2009) M Ming et al.   ONCOGENE

Requirement for Metalloproteinase-dependent ERK and AKT Activation in UVB-induced G1-S Cell Cycle Progression of Human Keratinocytes

(2009) Weinong Han et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cutaneous concentration of lycopene correlates significantly with the roughness of the skin

(2008) M DARVIN et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Skin DNA photodamage and its biological consequences

(2008) Laurent Marrot et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Lycopene has limited effect on cell proliferation in only two of seven human cell lines (both cancerous and noncancerous) in an in vitro system with doses across the physiological range

(2008) Lynn C. Burgess et al.   TOXICOLOGY IN VITRO