Article
Gastroenterology & Hepatology
Shiyan Wang, Shanshan Gao, Yong Zeng, Lin Zhu, Yulin Mo, Chi Chun Wong, Yi Bao, Peiran Su, Jianning Zhai, Lina Wang, Fraser Soares, Xin Xu, Huarong Chen, Kebria Hezaveh, Xinpei Ci, Aobo He, Tracy McGaha, Catherine O'Brien, Robert Rottapel, Wei Kang, Jianfeng Wu, Gang Zheng, Zongwei Cai, Jun Yu, Housheng Hansen He
Summary: The study identified a novel oncogenic epitranscriptome axis of YTHDF1-m(6)A-ARHGEF2 that regulates CRC tumorigenesis and metastasis.
Article
Biochemistry & Molecular Biology
Xin Zong, Xiao Xiao, Bin Shen, Qin Jiang, Hong Wang, Zeqing Lu, Fengqin Wang, Mingliang Jin, Junxia Min, Fudi Wang, Yizhen Wang
Summary: Recent evidence has shown that the N-6-methyladenosine (m(6)A) mRNA modification is closely associated with innate immunity, with the YTH domain-containing protein YTHDF1 playing a key role in regulating the immune response against bacterial pathogens in the intestine. Through interactions between the P/Q/N-rich domain in YTHDF1 and the DEAD domain in the host factor DDX60, YTHDF1 is involved in recognizing and regulating the immune response to bacterial infection in the intestines.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Hao-ze Shi, Jing-shu Xiong, Lu Gan, Ying Zhang, Cong-cong Zhang, Ying-qi Kong, Qiu-ju Miao, Cui-cui Tian, Rong Li, Jin-quan Liu, Er-jia Zhang, Wen-bo Bu, Yan Wang, Xian-feng Cheng, Jian-fang Sun, Hao Chen
Summary: This study found that m6A reader YTHDF3 plays an important role in the metastasis of melanoma. The downstream target of YTHDF3, LOXL3, was identified, and it was confirmed that YTHDF3 regulates the transcript of LOXL3 through m6A binding sites. Overexpression of LOXL3 weakened the inhibitory effect of YTHDF3 downregulation on melanoma metastasis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Chenhaoyi Xu, Huanghuang Huang, Min Zhang, Pei Zhang, Zezhi Li, Xueyuan Liu, Min Fang
Summary: Activity-regulated cytoskeleton-associated protein (ARC) plays an important role in the synaptic plasticity of memory consolidation. Abnormal expression of ARC in the brains of Alzheimer's Disease (AD) patients leads to disturbance of synaptic plasticity. N6-methyladenosine (m(6)A) might be involved in the epigenetic modification of ARC, and METTL3 rescues A beta-induced reduction of ARC expression through YTHDF1-dependent m(6)A modification, revealing an important mechanism of epigenetic alteration in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Cell Biology
Ganggang Zhai, Likang Xiao, Chenyang Jiang, Songkai Yue, Meng Zhang, Jia Zheng, Zeming Liu, Yonghui Dong
Summary: Recent studies have shown the importance of m6A modification in the development of osteoarthritis, indicating its potential significance for the treatment of OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Xu-Sheng Liu, Xue-Yan Kui, Yan Gao, Xue-Qin Chen, Jing Zeng, Xiao-Yu Liu, Yu Zhang, Yao-Hua Zhang, Zhi-Jun Pei
Summary: YTHDF1 is highly expressed in multiple tumors and may be involved in tumor progression. This study found that YTHDF1 is highly expressed in esophageal cancer and can serve as a biomarker for predicting tumor outcome. YTHDF1 expression is significantly associated with immune cell infiltration, glycolysis, and ferroptosis-related genes in esophageal cancer. Additionally, multiple ceRNA regulatory networks involving YTHDF1 were identified.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Yujie Zhang, Yanyan Wang, Liwei Ying, Sifeng Tao, Mingmin Shi, Peng Lin, Yangxin Wang, Bin Han
Summary: Osteosarcoma is the most common primary bone malignancy, typically seen in childhood or adolescence. Clinical outcomes for patients with osteosarcoma are usually poor due to the aggressive nature of the disease and limited treatment advances in the past four decades. Dysregulation of m(6)A-related factors in multiple osteosarcoma processes has been observed, indicating potential for future research and clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Lixia Ma, Li-na He, Shiyang Kang, Bianli Gu, Shegan Gao, Zhixiang Zuo
Summary: circRNAs are a class of noncoding RNAs with important biological functions, where m6A modification plays a crucial role in regulation. Accurate identification of m6A modification in circRNAs is a key step in research in this field.
Article
Biotechnology & Applied Microbiology
Zhipeng Ren, Yongcheng Hu, Jie Sun, Yuxiang Kang, Guishi Li, Hejun Zhao
Summary: This study reveals the critical role of m(6)A-modified lncRNA FOXD2-AS1 in osteosarcoma progression, by enhancing the stability of FOXD2-AS1 transcripts and forming a complex with FOXM1 mRNA, thereby promoting migration, proliferation, and tumor growth.
Article
Multidisciplinary Sciences
Juan Wang, Lei Wang, Xingfeng Tian, Lingping Luo
Summary: Asthma is a chronic respiratory disease with multiple pathologic molecular mechanisms, presenting a challenge to clinic nursing. Emerging evidence suggests that m6A plays critical roles in respiratory system disease. This study investigated the functions of m6A reader YTHDF1 in asthma and identified a novel axis of YTHDF1/m6A/cyclin D1 in airway remodeling, providing a potential therapeutic strategy.
Article
Agriculture, Dairy & Animal Science
Huanfa Gong, Tao Gong, Youhua Liu, Yizhen Wang, Xinxia Wang
Summary: In this research, m(6)A sequencing was used to discover genes that showed differential RNA expression and m(6)A modification between high and low IMF groups. ADIPOQ and SFRP1 were identified as hub genes through gene co-expression analysis. ADIPOQ, which contains m(6)A modification sites, was found to promote porcine intramuscular preadipocyte differentiation in an m(6)A-dependent manner, with YT521-B homology domain family protein 1 (YTHDF1) targeting and promoting ADIPOQ mRNA translation.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Immunology
Liting Guo, Hui Yang, Chenfei Zhou, Yan Shi, Lei Huang, Jun Zhang
Summary: N6-methyladenosine (m(6)A) methylation is a common RNA modification in eukaryotic cells which has significant impact on tumor immune microenvironment, affecting the initiation and progression of various cancers. The association between m(6)A methylation and immune cells in tumor immunity is complex, potentially offering novel markers and targets for molecular pathological diagnosis and immunotherapy of cancers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Haiyuan Mu, Ting Zhang, Ying Yang, Danru Zhang, Jie Gao, Junhong Li, Liang Yue, Dengfeng Gao, Bingbo Shi, Yue Han, Liang Zhong, Xinze Chen, Zhen-Bo Wang, Zhen Lin, Ming-Han Tong, Qing-Yuan Sun, Yun-Gui Yang, Jianyong Han
Summary: m(6)A modification plays essential roles in follicle development and oocyte growth, regulating oocyte meiosis by enhancing RNA stability.
CELL DEATH & DISEASE
(2021)
Review
Medicine, Research & Experimental
Junya Lv, Lijuan Xing, Xin Zhong, Kai Li, Mingyan Liu, Ke Du
Summary: N6-methyladenosine (m6A) is a common mRNA modification in eukaryotes, and its methylation is associated with various neurological disorders. Recent studies have shown that m6A-related drugs have potential therapeutic effects in treating neurological diseases. This review aims to summarize the role of m6A modification in neurological diseases and explore the therapeutic potential of m6A-related drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jeremy Scutenaire, Damien Plassard, Melody Matelot, Tommaso Villa, Julie Zumsteg, Domenico Libri, Bertrand Seraphin
Summary: This study investigates the role of m(6)A modification in meiosis. Using the yeast Saccharomyces cerevisiae, the researchers identified Pho92 as an important m(6)A reader that facilitates meiotic progression by promoting the down-regulation of specific mRNAs in a m(6)A-dependent manner.
NUCLEIC ACIDS RESEARCH
(2023)