Thermally Activated Delayed Fluorescence Material: An Emerging Class of Metal‐Free Luminophores for Biomedical Applications

Thermally Activated Delayed Fluorescence Featured Rigid Polyimides Affording Polymer Light‐Emitting Diodes with High External Quantum Efficiency Up to 21.0%

(2021) Yubo Long et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hot Vibrational States in a High-Performance Multiple Resonance Emitter and the Effect of Excimer Quenching on Organic Light-Emitting Diodes

(2021) Kleitos Stavrou et al.   ACS Applied Materials & Interfaces

A Dual Fluorescence‐Spin Label Probe for Visualization and Quantification of Target Molecules in Tissue by Multiplexed FLIM – EPR Spectroscopy

(2021) Pin Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acceptor–Donor–Acceptor‐Type Orange–Red Thermally Activated Delayed Fluorescence Materials Realizing External Quantum Efficiency Over 30% with Low Efficiency Roll‐Off

(2021) Durai Karthik et al.   ADVANCED MATERIALS

Highly Efficient Electroluminescence from Narrowband Green Circularly Polarized Multiple Resonance Thermally Activated Delayed Fluorescence Enantiomers

(2021) Yincai Xu et al.   ADVANCED MATERIALS

Optimizing Charge Transfer and Out‐Coupling of A Quasi‐Planar Deep‐Red TADF Emitter: towards Rec.2020 Gamut and External Quantum Efficiency beyond 30%

(2021) Hui Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances of redox-responsive nanoplatforms for tumor theranostics

(2021) Miaomiao Chen et al.   JOURNAL OF CONTROLLED RELEASE

Near‐Infrared‐Emitting Boron‐Difluoride‐Curcuminoid‐Based Polymers Exhibiting Thermally Activated Delayed Fluorescence as Biological Imaging Probes

(2021) Nathan R. Paisley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Purely Spin‐Vibronic Coupling Assisted Triplet to Singlet Up‐Conversion for Real Deep Blue Organic Light‐Emitting Diodes with Over 20% Efficiency and y Color Coordinate of 0.05

(2021) Vilas Venunath Patil et al.   Advanced Science

Color-Tunable Thermally Activated Delayed Fluorescence in Oxadiazole-Based Acrylic Copolymers: Photophysical Properties and Applications in Ratiometric Oxygen Sensing

(2020) Christopher M. Tonge et al.   ACS Applied Materials & Interfaces

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease

(2020) Jingyi Liu et al.   ACS Nano

Two-Dimensional Nanomaterials for Photothermal Therapy

(2020) Shuang Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Porphyrin-Based Metal-Organic Frameworks for Biomedical Applications

(2020) Yufang Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications

(2020) Xiaolei Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-Phase Thermally Activated Delayed Fluorescence Luminogens: A Material for Time-Resolved Imaging Independent of Probe Pretreatment and Probe Concentration

(2020) Xuping Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thermally activated triplet exciton release for highly efficient tri-mode organic afterglow

(2020) Jibiao Jin et al.   Nature Communications

Organic Thermally Activated Delayed Fluorescence Materials for Time‐Resolved Luminescence Imaging and Sensing

(2020) Fan Ni et al.   Advanced Optical Materials

Melanin‐Like Nanomaterials for Advanced Biomedical Applications: A Versatile Platform with Extraordinary Promise

(2020) Heng Liu et al.   Advanced Science

Achieving 21% External Quantum Efficiency for Nondoped Solution‐Processed Sky‐Blue Thermally Activated Delayed Fluorescence OLEDs by Means of Multi‐(Donor/Acceptor) Emitter with Through‐Space/‐Bond Charge Transfer

(2020) Xujun Zheng et al.   Advanced Science

Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes

(2020) Ji-Ting Hou et al.   Chem

1,8-Naphthalimide-Based Polymers Exhibiting Deep-Red Thermally Activated Delayed Fluorescence and Their Application in Ratiometric Temperature Sensing

(2020) Cheyenne J. Christopherson et al.   ACS Applied Materials & Interfaces

Multiresonant Thermally Activated Delayed Fluorescence Emitters Based on Heteroatom‐Doped Nanographenes: Recent Advances and Prospects for Organic Light‐Emitting Diodes

(2020) Subeesh Madayanad Suresh et al.   ADVANCED FUNCTIONAL MATERIALS

TADF Dye-Loaded Nanoparticles for Fluorescence Live-Cell Imaging

(2020) Carina I. C. Crucho et al.   Frontiers in Chemistry

Stimuli-Responsive Thermally Activated Delayed Fluorescence in Polymer Nanoparticles and Thin Films: Applications in Chemical Sensing and Imaging

(2020) Nathan R. Paisley et al.   Frontiers in Chemistry

Dual-mode Detection of Bacterial 16S Ribosomal RNA in Tissues

(2020) Shengnan Xu et al.   ACS Sensors

Stable Organic Photosensitizer Nanoparticles with Absorption Peak beyond 800 Nanometers and High Reactive Oxygen Species Yield for Multimodality Phototheranostics

(2020) Yingpeng Wan et al.   ACS Nano

Nanoparticles of Organic Electronic Materials for Biomedical Applications

(2020) Eshu Middha et al.   ACS Nano

Integrating Time‐Resolved Imaging Information by Single‐Luminophore Dual Thermally Activated Delayed Fluorescence

(2020) Mengkai Luo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Red/NIR Thermally Activated Delayed Fluorescence from Aza‐BODIPYs

(2020) Edurne Avellanal-Zaballa et al.   CHEMISTRY-A EUROPEAN JOURNAL

Self-Assembled Organic Nanomaterials for Drug Delivery, Bioimaging, and Cancer Therapy

(2020) Yinfeng Zhang et al.   ACS Biomaterials-Science & Engineering

Multi‐Layer π‐Stacked Molecules as Efficient Thermally Activated Delayed Fluorescence Emitters

(2020) Xue‐Qi Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances and perspectives in carrier-free nanodrugs for cancer chemo-monotherapy and combination therapy

(2020) Li Huang et al.   BIOMATERIALS

Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells

(2020) Chunyue Wang et al.   Photodiagnosis and Photodynamic Therapy

Hydrophilic, Red-Emitting, and Thermally Activated Delayed Fluorescence Emitter for Time-Resolved Luminescence Imaging by Mitochondrion-Induced Aggregation in Living Cells

(2019) Fan Ni et al.   Advanced Science

A three-dimensional ratiometric sensing strategy on unimolecular fluorescence–thermally activated delayed fluorescence dual emission

(2019) Xuping Li et al.   Nature Communications

Near-Infrared Afterglow Semiconducting Nano-Polycomplexes for the Multiplex Differentiation of Cancer Exosomes

(2019) Yan Lyu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitroreductase-Activatable Theranostic Molecules with High PDT Efficiency under Mild Hypoxia Based on a TADF Fluorescein Derivative

(2019) Zhiwei Liu et al.   ACS Applied Materials & Interfaces

A Highly Efficient Red Metal-free Organic Phosphor for Time-Resolved Luminescence Imaging and Photodynamic Therapy

(2019) Huifang Shi et al.   ACS Applied Materials & Interfaces

Bioluminescence Imaging of Inflammation in Vivo Based on Bioluminescence and Fluorescence Resonance Energy Transfer Using Nanobubble Ultrasound Contrast Agent

(2019) Renfa Liu et al.   ACS Nano

Developing Through-Space Charge Transfer Polymers as a General Approach to Realize Full-Color and White Emission with Thermally Activated Delayed Fluorescence

(2019) Jun Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

(2019) Jiaguo Huang et al.   NATURE MATERIALS

A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging

(2019) Yuyan Jiang et al.   Nature Communications

Thermally activated delayed fluorescent (TADF) coordination polymer with the generation of singlet oxygen

(2019) Xiu-Hui Ren et al.   Acta Crystallographica Section C-Structural Chemistry

A Biocompatible Free Radical Nanogenerator with Real‐Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy

(2019) Yingpeng Wan et al.   ADVANCED FUNCTIONAL MATERIALS

Unadulterated BODIPY nanoparticles for biomedical applications

(2019) Tao Zhang et al.   COORDINATION CHEMISTRY REVIEWS

A dual-targeted theranostic photosensitizer based on a TADF fluorescein derivative

(2019) Zhiwei Liu et al.   JOURNAL OF CONTROLLED RELEASE

Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy

(2019) Jinfeng Zhang et al.   ACS Applied Materials & Interfaces

High‐Performance Nondoped Blue Delayed Fluorescence Organic Light‐Emitting Diodes Featuring Low Driving Voltage and High Brightness

(2019) Shi‐Jie Zou et al.   Advanced Science

Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid

(2018) Qingqing Miao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thermally activated delayed fluorescence organic dots for two-photon fluorescence lifetime imaging

(2018) Tingchao He et al.   APPLIED PHYSICS LETTERS

Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing

(2018) Kenneth Yin Zhang et al.   CHEMICAL REVIEWS

Iridium nanoparticles for multichannel luminescence lifetime imaging, mapping localization in live cancer cells

(2018) Siobhan M King et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

(2018) Guangbao Yang et al.   NANO LETTERS

A FRET chemosensor for hypochlorite with large Stokes shifts and long-lifetime emissions

(2018) Zhiwei Liu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Organic emitter integrating aggregation-induced delayed fluorescence and room-temperature phosphorescence characteristics, and its application in time-resolved luminescence imaging

(2018) Fan Ni et al.   Chemical Science

Maximizing Aggregation of Organic Fluorophores to Prolong Fluorescence Lifetime for Two-Photon Fluorescence Lifetime Imaging

(2018) Wenbo Hu et al.   Advanced Healthcare Materials

Chemical and conformational control of the energy gaps involved in the thermally activated delayed fluorescence mechanism

(2018) Paloma L. dos Santos et al.   Journal of Materials Chemistry C

All-organic thermally activated delayed fluorescence materials for organic light-emitting diodes

(2018) Yuchao Liu et al.   Nature Reviews Materials

Polymerization-Enhanced Photosensitization

(2018) Wenbo Wu et al.   Chem

Thermally Activated Delayed Fluorescence (TADF) Path toward Efficient Electroluminescence in Purely Organic Materials: Molecular Level Insight

(2018) Xian-Kai Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics

(2018) Dong Wang et al.   ADVANCED MATERIALS

Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging

(2018) Yong Fan et al.   Nature Nanotechnology

Delivery of Phosphorescent Anticancer Iridium(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal-Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging

(2018) Dong-Yang Zhang et al.   Advanced Science

Cell-Penetrating Peptides Transport Noncovalently Linked Thermally Activated Delayed Fluorescence Nanoparticles for Time-Resolved Luminescence Imaging

(2018) Zece Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-Infrared Light-Initiated Molecular Superoxide Radical Generator: Rejuvenating Photodynamic Therapy against Hypoxic Tumors

(2018) Mingle Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy

(2018) Kaiyuan Ni et al.   Nature Communications

A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Blue Thermally Activated Delayed Fluorescence Polymers with Nonconjugated Backbone and Through-Space Charge Transfer Effect

(2017) Shiyang Shao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Up-Conversion Intersystem Crossing Rates in Organic Emitters for Thermally Activated Delayed Fluorescence: Impact of the Nature of Singlet vs Triplet Excited States

(2017) Pralok K. Samanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular afterglow imaging with bright, biodegradable polymer nanoparticles

(2017) Qingqing Miao et al.   NATURE BIOTECHNOLOGY

Regio- and conformational isomerization critical to design of efficient thermally-activated delayed fluorescence emitters

(2017) Marc K. Etherington et al.   Nature Communications

Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo

(2017) Jinfeng Zhang et al.   Theranostics

Thermally Activated Delayed Fluorescence Organic Dots (TADF Odots) for Time-Resolved and Confocal Fluorescence Imaging in Living Cells and In Vivo

(2017) Tingting Li et al.   Advanced Science

An Alternative Host Material for Long-Lifespan Blue Organic Light-Emitting Diodes Using Thermally Activated Delayed Fluorescence

(2017) Soo-Ghang Ihn et al.   Advanced Science

Near-infrared fluorophores for biomedical imaging

(2017) Guosong Hong et al.   Nature Biomedical Engineering

Self-Assembly of Electron Donor–Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging

(2016) Jinfeng Zhang et al.   ACS Applied Materials & Interfaces

Bifunctional Platinated Nanoparticles for Photoinduced Tumor Ablation

(2016) Zhengqing Guo et al.   ADVANCED MATERIALS

Organic nanostructures of thermally activated delayed fluorescent emitters with enhanced intersystem crossing as novel metal-free photosensitizers

(2016) Jinfeng Zhang et al.   CHEMICAL COMMUNICATIONS

The Importance of Vibronic Coupling for Efficient Reverse Intersystem Crossing in Thermally Activated Delayed Fluorescence Molecules

(2016) Jamie Gibson et al.   CHEMPHYSCHEM

Mechanism of the Triplet-to-Singlet Upconversion in the Assistant Dopant ACRXTN

(2016) Christel M. Marian   Journal of Physical Chemistry C

Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors

(2016) Simon Haziza et al.   Nature Nanotechnology

Revealing the spin–vibronic coupling mechanism of thermally activated delayed fluorescence

(2016) Marc K. Etherington et al.   Nature Communications

Enabling the Triplet of Tetraphenylethene to Sensitize the Excited State of Europium(III) for Protein Detection and Time-Resolved Luminescence Imaging

(2016) Zece Zhu et al.   Advanced Science

Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with a Large Stokes Shift for Noninvasive Long-Term Cellular Imaging

(2015) Jinfeng Zhang et al.   ACS Applied Materials & Interfaces

Gated Luminescence Imaging of Silicon Nanoparticles

(2015) Jinmyoung Joo et al.   ACS Nano

Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo

(2015) Jinfeng Zhang et al.   ACS Nano

Nearly 100% Internal Quantum Efficiency in Undoped Electroluminescent Devices Employing Pure Organic Emitters

(2015) Qisheng Zhang et al.   ADVANCED MATERIALS

Nanoparticles in Photodynamic Therapy

(2015) Sasidharan Swarnalatha Lucky et al.   CHEMICAL REVIEWS

Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy

(2015) Guosong Hong et al.   CHEMICAL REVIEWS

Nature of Highly Efficient Thermally Activated Delayed Fluorescence in Organic Light-Emitting Diode Emitters: Nonadiabatic Effect between Excited States

(2015) Xian-Kai Chen et al.   Journal of Physical Chemistry C

Oxygen Sensing Difluoroboron Dinaphthoylmethane Polylactide

(2015) Christopher A. DeRosa et al.   MACROMOLECULES

Highly stable organic fluorescent nanorods for living-cell imaging

(2015) Minhuan Lan et al.   Nano Research

Self-carried curcumin nanoparticles for in vitro and in vivo cancer therapy with real-time monitoring of drug release

(2015) Jinfeng Zhang et al.   Nanoscale

Kinetics of thermal-assisted delayed fluorescence in blue organic emitters with large singlet-triplet energy gap

(2015) F. B. Dias   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics

(2015) Shidang Xu et al.   Chemical Science

Ultrasmall Gold Nanoparticles as Carriers for Nucleus-Based Gene Therapy Due to Size-Dependent Nuclear Entry

(2014) Shuaidong Huo et al.   ACS Nano

Thermally Activated Delayed Fluorescence Materials Towards the Breakthrough of Organoelectronics

(2014) Ye Tao et al.   ADVANCED MATERIALS

Targetable Phosphorescent Oxygen Nanosensors for the Assessment of Tumor Mitochondrial Dysfunction By Monitoring the Respiratory Activity

(2014) Xiao-Hui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bright, Highly Water-Soluble Triazacyclononane Europium Complexes To Detect Ligand Binding with Time-Resolved FRET Microscopy

(2014) Martina Delbianco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thermally Activated Delayed Fluorescence of Fluorescein Derivative for Time-Resolved and Confocal Fluorescence Imaging

(2014) Xiaoqing Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Histidine–Iridium(III) Coordination-Based Peptide Luminogenic Cyclization and Cyclo-RGD Peptides for Cancer-Cell Targeting

(2014) Xiaochuan Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

Cationic Polyfluorenes with Phosphorescent Iridium(III) Complexes for Time-Resolved Luminescent Biosensing and Fluorescence Lifetime Imaging

(2013) Huifang Shi et al.   ADVANCED FUNCTIONAL MATERIALS

Sensing and Imaging of Oxygen with Parts per Billion Limits of Detection and Based on the Quenching of the Delayed Fluorescence of 13C70 Fullerene in Polymer Hosts

(2013) Sven Kochmann et al.   ANALYTICAL CHEMISTRY

Triplet photosensitizers: from molecular design to applications

(2013) Jianzhang Zhao et al.   CHEMICAL SOCIETY REVIEWS

Red-Emissive Fluorescein Derivatives and Detection of Bovine Serum Albumin

(2013) Xiaoqing Xiong et al.   Asian Journal of Organic Chemistry

Direct cytosolic delivery of cargoes in vivo by a chimera consisting of D- and L-arginine residues

(2012) Yan Ma et al.   JOURNAL OF CONTROLLED RELEASE

Highly efficient organic light-emitting diodes from delayed fluorescence

(2012) Hiroki Uoyama et al.   NATURE

Cell-penetrating peptides: breaking through to the other side

(2012) Erez Koren et al.   TRENDS IN MOLECULAR MEDICINE

Efficient up-conversion of triplet excitons into a singlet state and its application for organic light emitting diodes

(2011) Ayataka Endo et al.   APPLIED PHYSICS LETTERS

Emerging nanomaterials for targeting subcellular organelles

(2011) Jasper G. Huang et al.   Nano Today

Harvesting luminescence via harnessing the photophysical properties of transition metal complexes

(2010) Pi-Tai Chou et al.   COORDINATION CHEMISTRY REVIEWS

Thermally Activated Delayed Fluorescence from Sn4+-Porphyrin Complexes and Their Application to Organic Light Emitting Diodes - A Novel Mechanism for Electroluminescence

(2009) Ayataka Endo et al.   ADVANCED MATERIALS

Transition-metal phosphors with cyclometalating ligands: fundamentals and applications

(2009) Yun Chi et al.   CHEMICAL SOCIETY REVIEWS

Oxygen-proof fluorescence temperature sensing with pristine C70encapsulated in polymernanoparticles

(2009) Vera Augusto et al.   JOURNAL OF MATERIALS CHEMISTRY