Article
Medicine, General & Internal
Vered H. Eisenberg, Dean H. Decter, Gabriel Chodick, Varda Shalev, Clara Weil
Summary: The goal of this study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. The study found that endometriosis was significantly associated with infertility, comorbidities, higher utilization of healthcare services, pain medications, and antidepressants, as well as higher direct medical costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Antonios Douros, Christina Santella, Sophie Dell'Aniello, Laurent Azoulay, Christel Renoux, Samy Suissa, Paul Brassard
Summary: The study found that infectious disease burden was associated with an increased risk of Alzheimer's disease (AD), with the risk gradually increasing with longer time since first infection. However, the risk did not increase with cumulative number of infections.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Elahe Amini, Mehdi Moghaddasi, Seyed Amir Hassan Habibi, Zahra Azad, Shahnaz Miri, Naveed Nilforushan, Reza Mirshahi, Esther Cubo, Nahid Mohammadzadeh, Mohammad Rohani
Summary: Retinal thickness and retinal nerve fiber layer were found to be reduced in patients with Huntington's disease (HD) using spectral-domain optical coherence tomography. These findings support the hypothesis that the retina could serve as a potential biomarker for monitoring the neurodegenerative process in HD.
NEUROLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Irene Soles-Tarres, Nuria Cabezas-Llobet, Benjamin Lefranc, Jerome Leprince, Jordi Alberch, David Vaudry, Xavier Xifro
Summary: This study found that PACAP can exert antiapoptotic and neurotrophic effects on neuronal cells in Huntington's disease (HD) through the PAC1R receptor. In a mouse model, intranasal administration of PACAP restored motor function and increased levels of PAC1R, CBP, and BDNF in the striatum.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Idaira Rodriguez-Santana, Tiago Mestre, Ferdinando Squitieri, Rosa Willock, Astri Arnesen, Alison Clarke, Barbara D'Alessio, Alex Fisher, Rebecca Fuller, Jamie L. Hamilton, Hayley Hubberstey, Cath Stanley, Louise Vetter, Michaela Winkelmann, Maria Doherty, Yunchou Wu, Alan Finnegan, Samuel Frank
Summary: This study estimates the economic burden of Huntington disease (HD) by analyzing the direct medical, nonmedical, and indirect costs associated with HD based on the Huntington's Disease Burden of Illness (HDBOI) study. The results show that the economic burden for individuals with HD and their caregivers increases as the disease progresses.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Sameer Desai, Wei Zhang, Jason M. Sutherland, Joel Singer, Bradley S. Quon
Summary: Cystic fibrosis (CF) is a progressive multi-organ disease that places extensive demands on the healthcare system. This study found that individuals with severe lung impairment, lung transplantation, liver cirrhosis with portal hypertension, and female sex were more likely to become frequent high-cost CF users. These high-cost users accounted for more than one-third of the overall healthcare costs, primarily due to inpatient hospitalization and outpatient medication costs.
SCIENTIFIC REPORTS
(2023)
Article
Information Science & Library Science
Sezgin Ayabakan, Indranil R. Bardhan, Zhiqiang (Eric) Zheng
Summary: Technological advancements and the COVID-19 pandemic have accelerated process virtualization, particularly in healthcare where telehealth has greatly transformed care delivery. However, telehealth can increase healthcare spending if it leads to new types of resource utilization. By analyzing visit-level patient data, this study finds that telehealth visits reduce future outpatient visits by 13.6% on average, resulting in a cost reduction of $239 within 30 days after the visit. The benefits of telehealth are more pronounced for diseases with high virtualization potential, such as mental health, skin, metabolic, and musculoskeletal diseases. The findings highlight the importance of promoting telehealth use in a value-based healthcare system, particularly for diseases with high virtualization potential.
INFORMATION SYSTEMS RESEARCH
(2023)
Article
Economics
Alex Exuzides, Tu My To, Ibrahim M. Abbass, Jamie T. Ta, Anisha M. Patel, Andy Surinach, Rebecca L. M. Fuller, Jia Luo
Summary: This study aimed to quantify healthcare resource utilization and costs by disease stage in individuals with Huntington's disease (HD) in a US population. The findings suggest that the burden of care is high among individuals with HD, particularly among those with middle- and late-stage disease.
JOURNAL OF MEDICAL ECONOMICS
(2022)
Article
Clinical Neurology
Glenn Phillips, Catarina Abreu, Amit Goyal, Yuebing Li, Albert Whangbo, Deborah Gelinas, Edward Brauer, Sankha Bhattacharya
Summary: This study investigated healthcare resource utilization and associated costs for adults with generalized myasthenia gravis (gMG) in the United States. The results showed that newly diagnosed patients had higher healthcare resource utilization and costs compared to previously diagnosed patients, and costs further increased for patients with exacerbation events. For patients who experienced crisis events, costs significantly increased during the 12 months before the event and further increased in the 12 months following the event. The high costs were largely attributed to the treatments received.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Carel W. le Roux, Niels Hartvig, Christiane Lundegaard Haase, Rikke Baastrup Nordsborg, Anne Helene Olsen, Altynai Satylganova
Summary: The joint effect of obesity and cardiovascular risk status on healthcare resource utilization was examined in a UK database study, showing that higher BMI categories and established CVD patients had greater healthcare resource utilization. Timely management of obesity and CVD-risk factors is important in preventing increasing healthcare resource utilization.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paolo Tucci, Roberta Lattanzi, Cinzia Severini, Luciano Saso
Summary: In this review, we present the scientific literature supporting the role of nuclear transcription factor-2 (Nrf2) in Huntington's disease (HD) and the potential prophylactic and therapeutic role of this compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Peter Anglin, Julia Elia-Pacitti, Maria Eberg, Sergey Muratov, Atif Kukaswadia, Arushi Sharma, Emmanuel M. Ewara
Summary: A retrospective study in Canada reveals that mantle cell lymphoma (MCL) poses a significant burden to the healthcare system, with nearly half of the patients requiring second-line therapy or dying within 3 years.
Article
Rheumatology
Nadia M. T. Roodenrijs, Paco M. J. Welsing, Marlies C. van der Goes, Janneke Tekstra, Floris P. J. G. Lafeber, Johannes W. G. Jacobs, Jacob M. van Laar
Summary: The economic burden of difficult-to-treat rheumatoid arthritis (D2T RA) is significantly higher than that of non-D2T RA, indicated by higher healthcare utilization and annual total costs. Functional disability is a key determinant of higher costs in RA.
Article
Economics
Tu My To, Jamie T. Ta, Anisha M. Patel, Stella Arndorfer, Ibrahim M. Abbass, Rita Gandhy
Summary: This study quantified healthcare resource utilization and costs for individuals with late-onset Huntington's disease (LoHD), comparing them with adult-onset HD (AoHD) and non-HD controls. The results showed that LoHD patients had significantly higher healthcare burden and costs than non-HD controls, similar to AoHD patients. This highlights the significant healthcare burden associated with LoHD.
JOURNAL OF MEDICAL ECONOMICS
(2023)
Article
Public, Environmental & Occupational Health
Yingyan Ma, Yuechun Wen, Hua Zhong, Senlin Lin, Li Liang, Yifang Yang, Huifen Jiang, Jian Chen, Yan Huang, Xiaohua Ying, Serge Resnikoff, Lina Lu, Jianfeng Zhu, Xun Xu, Xiangui He, Haidong Zou
Summary: This study investigates the utilization of various correction methods and health service for myopia in urban China and estimates the costs of treatment, prevention, and productivity loss. The findings reveal that myopia poses a substantial economic burden in China.
JOURNAL OF GLOBAL HEALTH
(2022)