Article
Pharmacology & Pharmacy
Wen Luo, Li Jia, Jia-Wen Zhang, Dong-Jie Wang, Qiu Ren, Wei Zhang
Summary: The study found that Andro exhibited significant protective effects against lung cancer, and metabolomics combined with network pharmacology analysis provided insight into its therapeutic mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Junqian Zhang, Chunjie Li, Li Zhang, Yongqing Heng, Tong Xu, Yunjing Zhang, Xihui Chen, Robert M. Hoffman, Lijun Jia
Summary: Andrographolide (AD) inhibits the proliferation of lung cancer cell lines and induces apoptosis in human lung adenocarcinoma cells by activating the ATF4/Noxa axis, supporting its potential as a candidate for chemotherapy in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Seung Yeob Hyun, Hye-Young Min, Ho Jin Lee, Jaebeom Cho, Hye-Jin Boo, Myungkyung Noh, Hyun-Ji Jang, Hyo-Jong Lee, Choon-Sik Park, Jong-Sook Park, Young Kee Shin, Ho-Young Lee
Summary: Ninj1 is elevated in lung cancer and plays a role in tumor formation and progression. Elevated Ninj1 expression serves as a biomarker for poor prognosis in lung cancer patients, and Ninj1 is involved in protecting lung cancer stem cells from hostile microenvironments.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ourania S. Kotsiou, Dimitrios Papagiannis, Rodanthi Papadopoulou, Konstantinos I. Gourgoulianis
Summary: This review provides insights into the potential role of Calprotectin in the pathophysiology of lung diseases, highlighting its multifunctionality in cellular processes and emphasizing its potential as a biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Philippe Rochigneux, Aaron Lisberg, Alejandro Garcia, Samuel Granjeaud, Anne Madroszyk, Stephane Fattori, Anthony Goncalves, Raynier Devillier, Pauline Maby, Nassim Salem, Laurent Gorvel, Brice Chanez, Jaklin Gukasyan, James Carroll, Jonathan Goldman, Anne Sophie Chretien, Daniel Olive, Edward B. Garon
Summary: In this study, high-dimensional mass cytometry was used to analyze baseline blood samples of patients with advanced NSCLC treated with pembrolizumab. The study found that baseline frequencies of certain immune cell populations were significantly associated with improved effectiveness of pembrolizumab, and a baseline immune peripheral score was established to predict pembrolizumab efficacy.
CLINICAL CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xuan-Run Wang, Ze-Bo Jiang, Cong Xu, Wei-Yu Meng, Pei Liu, Yi-Zhong Zhang, Chun Xie, Jing-Yi Xu, Ya-Jia Xie, Tu-Liang Liang, Hao-Xin Yan, Xing-Xing Fan, Xiao-Jun Yao, Qi-Biao Wu, Elaine Lai-Han Leung
Summary: Andrographolide (AD) in the treatment of non-small-cell lung cancer (NSCLC) involves regulating autophagy and PD-L1 expression, inhibiting tumour growth by suppressing JAK2/STAT3 signaling and P62-dependent selective autophagy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Tangjia Li, Chu Zhang, Yuke Wei, Haijing Zhong, Luchen Shan, Pei Yu, Yuqiang Wang, Lipeng Xu
Summary: This study demonstrates that AL-1 effectively alleviates LPS-induced lung injury by reducing proinflammatory cytokine levels, inflammatory responses, and infiltration of inflammatory cells, thereby improving pathological changes in lung tissue.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Genetics & Heredity
Fanny Pineau, Davide Caimmi, Sylvie Taviaux, Maurane Reveil, Laura Brosseau, Isabelle Rivals, Margot Drevait, Isabelle Vachier, Mireille Claustres, Raphael Chiron, Albertina De Sario
Summary: Cystic fibrosis is a chronic genetic disease that affects the respiratory and gastrointestinal systems. This study identified a DNA methylation biomarker that correlates with CF severity and provided a method for easy assessment. Additionally, it conducted the first longitudinal analysis of DNA methylation in CF patients, suggesting potential use of this epigenetic biomarker in stratifying CF patients in clinical trials.
Article
Clinical Neurology
Eleonora M. Vromen, Sterre C. M. de Boer, Charlotte E. Teunissen, Annemieke Rozemuller, Anne Sieben, Maria Bjerke, Pieter Jelle Visser, Femke H. Bouwman, Sebastiaan Engelborghs, Betty M. Tijms
Summary: The biological definition of Alzheimer's disease using CSF biomarkers requires both abnormal amyloid and tau levels. However, a recent multicenter study found that up to 73% of individuals with normal CSF levels of both amyloid and tau had Alzheimer's disease at autopsy, suggesting the biomarkers may not always accurately reflect disease presence or absence. This finding has important implications for both research and clinical settings, and highlights the need for further investigation into the use of CSF biomarkers in diagnosing Alzheimer's disease.
Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: PTENP1, initially thought to be a pseudogene of the PTEN tumor suppressor gene, has been identified as a biologically active long non-coding RNA. It functions as a competing endogenous RNA and plays a crucial role in various malignant conditions and non-malignant diseases.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Marcel E. Dinger, Parichehr Maleki, Mohammad Taheri, Mohammadreza Hajiesmaeili
Summary: circRNAs have been proposed as molecular markers for lung cancer due to their stability in blood, showing potential value in disease detection. Dysregulation of circRNAs in lung cancer tissues suggests their potential involvement in carcinogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Jingwei Li, Qiran Zhang, Decheng Jiang, Jun Shao, Weimin Li, Chengdi Wang
Summary: Lung cancer has the highest mortality rate among malignancies worldwide. Circular RNAs (circRNAs), a type of covalently closed molecules, show potential clinical application prospects in lung cancer. This review explains the biogenesis, biological functions, and pathophysiology of circRNAs, and highlights their forefront in the diagnosis, prognosis, and therapy of lung cancer.
Article
Biochemistry & Molecular Biology
Shruti Magesh, Pranava Gande, Rishabh Yalamarty, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Summary: In this study, the expression of transfer RNA-derived fragments (tRFs) was analyzed in lung squamous cell carcinoma (LUSC) to investigate their association with etiology and clinical outcomes. The results showed significant differences in tRF expression among different subtypes of LUSC, and these tRFs were correlated with patient survival. Particularly, tRF expression in smoking-induced LUSC and non-smoking-induced LUSC was associated with cancer stage and treatment efficacy. These findings may contribute to the development of improved diagnostic and therapeutic approaches for LUSC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Adriana Zardini Buzatto, Mai Abdel Jabar, Imran Nizami, Majed Dasouki, Liang Li, Anas M. Abdel Rahman
Summary: Cystic fibrosis is a genetic disease characterized by abnormal accumulation of mucus in various body tracts, caused by mutations in the CFTR gene. Lipid metabolism alterations related to the disease and different genotypic mutations have been uncovered through comprehensive lipidomics analysis, suggesting potential therapeutic targets. Dyslipidemia, particularly in odd-chain and polyunsaturated fatty acyl lipids, was observed in cystic fibrosis patients, alongside affected phosphatidic acids and diacylglycerols influenced by different genotypic mutation classes. Biomarker panels composed of specific lipids were able to classify patients and differentiate those with reduced lung function, providing valuable insights for future research and treatment.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Atefe Abak, Farhad Tondro Anamag, Hamed Shoorei, Faranak Fattahi, Seyed Alireza Javadinia, Abbas Basiri, Mohammad Taheri
Summary: Non-coding RNAs play a central role in determining the response of patients to 5-FU by modulating cancer-related pathways and cell behavior; Modulating the expression levels of microRNAs or long non-coding RNAs may sensitize tumor cells to 5-FU treatment; There is increasing interest in targeting these transcripts in various cancers treated with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Respiratory System
Yi Liao, Yue Liao, Fuqiang Wen
Summary: This meta-analysis suggests that HHIP gene polymorphisms may be associated with the risk of COPD. Certain single-nucleotide polymorphisms were found to increase the risk of COPD in Asian and Caucasian individuals. These findings provide a theoretical basis for further investigating the genetic mechanisms of COPD.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Dingyi Wang, Guohui Fan, Sinan Wu, Ting Yang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Guodong Xu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Wen Li, Liren Ding, Chun Wan, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Xiaoning Bu, Hong Zhang, Xiaolei Zhang, Li An, Shu Zhang, Jianguo Zhu, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Huaping Dai, Bin Cao, Jiang He, Chen Wang
Summary: This study aimed to develop an easy-to-use screening questionnaire for COPD in primary health care settings. The questionnaire was developed based on a nationwide epidemiological study in mainland China. The scoring system showed good discrimination and needs further validation in larger cohorts.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Article
Environmental Sciences
Yalan Xiao, Xiaoying Gu, Hongtao Niu, Xia Meng, Lina Zhang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Diandian Li, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Bin Cao, Huaping Dai, Tangchun Wu, Jiang He, Haidong Kan, Renjie Chen, Ting Yang, Chen Wang
Summary: The study found that residential greenness in China is associated with better lung function and lower prevalence of COPD, particularly among middle-aged and young individuals, females, and non-smokers. These findings provide a scientific basis for healthy community planning.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Sarowar Muhammad Golam, Christer Janson, Richard Beasley, J. Mark FitzGerald, Tim Harrison, Bradley Chipps, Rod Hughes, Hana Mullerov, Jose Maria Olaguibel, Eleni Rapsomaniki, Helen K. Reddel, Mohsen Sadatsafavi, N. O. V. E. L. T. Y. investigators NOVELTY invest
Summary: The study found that a significant proportion of patients with physician-assessed mild asthma experienced considerable clinical burden and healthcare resource utilization.
RESPIRATORY MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Guangming He, Keling Chen, Hao Wang, Xiaoou Li, Wenhao Li, Lian Liu, Jun Chen, Deqing Yang, Jun Hu, Dan Xu, Fuqiang Wen, Tao Wang
Summary: This study investigates the effects and mechanisms of fudosteine in sepsis-induced acute lung injury. The results show that fudosteine can reduce inflammation and oxidative stress, and protect against lung injury by inhibiting pyroptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Respiratory System
Alvar Agusti, Eleni Rapsomaniki, Richard Beasley, Rod Hughes, Hana Mullerova, Alberto Papi, Ian D. Pavord, Maarten van den Berge, Rosa Faner
Summary: This study assessed the prevalence and relationship of treatable traits (TTs) to the diagnostic label and disease severity in real-world setting for patients with asthma, COPD, or both. The results provide the largest and most granular characterization of TTs in patients with airway diseases to date.
Article
Respiratory System
Jiangyue Qin, Hao Wang, Zhuoyao Lyu, Yue Liao, Ni Zeng, Ke Wang, Yongfang Zhou, Zijian Zeng, Zenglin Liao, Yufang Cao, Junyun He, Tao Wang, Fuqiang Wen
Summary: This study investigated the clinical value of soluble DR5 and TRAIL in prognosis assessment of ARDS. The results showed that elevated serum DR5 levels were associated with increased mortality in ARDS patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shuyan Wang, Rui Zhang, Chun Wan, Jiangyue Qin, Xueru Hu, Yongchun Shen, Lei Chen, Fuqiang Wen
Summary: This meta-analysis comprehensively summarized the clinical complications of indwelling pleural catheter (IPC). The overall incidence of IPC complications was 20.3%, with infection being the most common complication. Patients with liver-related pleural effusion had a significantly higher infection incidence compared to patients with heart-related pleural effusion.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Pathology
Yi Liao, Ran Wang, Fuqiang Wen
Summary: This study found that lncRNA has significant potential as a diagnostic and prognostic biomarker for sepsis patients, improving diagnostic accuracy and prognostic assessment.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Medicine, Research & Experimental
Ke Wang, Youyu Wang, Yufang Cao, Hao Wang, Yongfang Zhou, Lijuan Gao, Zijian Zeng, Mengxin Cheng, Xiaodong Jin, Jun Chen, Fuqiang Wen, Tao Wang
Summary: This study found that lumican is increased in the early phase of acute respiratory distress syndrome (ARDS), and is associated with disease severity and inflammatory fibrotic processes. Lumican promotes fibrotic responses in ARDS by triggering the transdifferentiation of lung fibroblasts into myofibroblasts and epithelial-mesenchymal transition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Yi Liao, Ran Wang, Fuqiang Wen
Summary: SPP1 is a potential diagnostic and prognostic biomarker for patients with IPF. It has high sensitivity and specificity in distinguishing between IPF and lung cancer patients.
Article
Immunology
Ke Wang, Yue Liao, Xiaoou Li, Ran Wang, Zijian Zeng, Mengxin Cheng, Lijuan Gao, Dan Xu, Fuqiang Wen, Tao Wang, Jun Chen
Summary: Chronic obstructive pulmonary disease (COPD) is a global public health challenge caused by significant exposure to noxious agents, especially cigarette smoke. Excessive production of neutrophil extracellular traps (NETs) in the airways is associated with the severity of COPD. In this study, the inhibitor GW311616A was found to effectively prevent cigarette smoke-induced NET formation in human neutrophil cells by blocking the nuclear translocation of neutrophil elastase (NE) and subsequent chromatin decondensation. Inhibition of NE also improved lung function and attenuated COPD-related pathological changes in a mouse model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Respiratory System
Yue Liao, Hao Wang, Ke Wang, Kai Zi, Yongchun Shen, Lei Chen, Tao Wang, Jun Chen, Fuqiang Wen
Summary: This study investigated the efficacy of tiotropium bromide inhalation (TBI) in symptomatic Chinese patients with COPD. After 3 months of treatment, patients showed significant improvements in lung function, symptoms, and a decrease in exacerbations.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Wei Xiao, Longyi Du, Linli Cai, Tiwei Miao, Bing Mao, Fuqiang Wen, Peter Gerard Gibson, Deying Gong, Yan Zeng, Mei Kang, Xinmiao Du, Junyan Qu, Yan Wang, Xuemei Liu, Ruizhi Feng, Juanjuan Fu
Summary: This study evaluated the utility of different mycological tests in diagnosing invasive pulmonary aspergillosis in non-hematological patients with respiratory diseases. The results suggest that sputum GM and LFD assays may be effective alternatives to BAL GM test.
CHINESE MEDICAL JOURNAL
(2022)
Article
Respiratory System
Kewu Huang, Xiaoying Gu, Ting Yang, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Sinan Wu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Wen Li, Liren Ding, Chun Wan, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Dan Xiao, Xiaoning Bu, Hong Zhang, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Huaping Dai, Bin Cao, Jiang He, Kian Fan Chung, Chen Wang
Summary: The prevalence of chronic cough is high in China, particularly in individuals aged 50 and above and those diagnosed with COPD or SAD. Chronic cough is associated with a poorer health status, with varying degrees of impact depending on age and disease diagnosis.