Mechanisms of DNA Mobilization and Sequestration

Loop extrusion as a mechanism for formation of DNA damage repair foci

(2021) Coline Arnould et al.   NATURE

Bridging-induced phase separation induced by cohesin SMC protein complexes

(2021) Je-Kyung Ryu et al.   Science Advances

The rDNA is biomolecular condensate formed by polymer–polymer phase separation and is sequestered in the nucleolus by transcription and R-loops

(2021) Josh Lawrimore et al.   NUCLEIC ACIDS RESEARCH

Integrative analysis reveals unique structural and functional features of the Smc5/6 complex

(2021) You Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavior of dicentric chromosomes in budding yeast

(2021) Diana Cook et al.   PLoS Genetics

Ca2+ Microdomains, Calcineurin and the Regulation of Gene Transcription

(2021) Gerald Thiel et al.   Cells

Activation of a signaling pathway by the physical translocation of a chromosome

(2021) Mathilde Guzzo et al.   DEVELOPMENTAL CELL

Force generation by protein–DNA co-condensation

(2021) Thomas Quail et al.   Nature Physics

High Temporal Resolution 3D Live-Cell Imaging of Budding Yeast Meiosis Defines Discontinuous Actin/Telomere-Mediated Chromosome Motion, Correlated Nuclear Envelope Deformation and Actin Filament Dynamics

(2021) Tadasu Nozaki et al.   Frontiers in Cell and Developmental Biology

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

(2020) Fabian Erdel et al.   MOLECULAR CELL

Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins

(2020) Xiangze Zeng et al.   BIOPHYSICAL JOURNAL

Control of the chromatin response to DNA damage: Histone proteins pull the strings

(2020) Juliette Ferrand et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chromosome Structural Mechanics Dictates the Local Spreading of Epigenetic Marks

(2020) Sarah H. Sandholtz et al.   BIOPHYSICAL JOURNAL

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Statistical mechanics of chromosomes: in vivo and in silico approaches reveal high-level organization and structure arise exclusively through mechanical feedback between loop extruders and chromatin substrate properties

(2020) Yunyan He et al.   NUCLEIC ACIDS RESEARCH

Rheological Tuning of Entangled Polymer Networks by Transient Crosslinks

(2019) Xue-Zheng Cao et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes

(2019) Marius Socol et al.   NUCLEIC ACIDS RESEARCH

Suppressor screening reveals common kleisin–hinge interaction in condensin and cohesin, but different modes of regulation

(2019) Xingya Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex

(2019) Prasad Trivedi et al.   NATURE CELL BIOLOGY

Transient crosslinking kinetics optimize gene cluster interactions

(2019) Benjamin Walker et al.   PLoS Computational Biology

Common Features of the Pericentromere and Nucleolus

(2019) Colleen J. Lawrimore et al.   Genes

Formation of Chromatin Subcompartments by Phase Separation

(2018) Fabian Erdel et al.   BIOPHYSICAL JOURNAL

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Chromatin and nucleosome dynamics in DNA damage and repair

(2017) Michael H. Hauer et al.   GENES & DEVELOPMENT

Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage

(2017) Christopher Bot et al.   JOURNAL OF CELL SCIENCE

Multi-scale tracking reveals scale-dependent chromatin dynamics after DNA damage

(2017) Judith Miné-Hattab et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage

(2017) Josh Lawrimore et al.   MOLECULAR BIOLOGY OF THE CELL

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enrichment of dynamic chromosomal crosslinks drive phase separation of the nucleolus

(2017) Caitlin Hult et al.   NUCLEIC ACIDS RESEARCH

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

(2017) Michael H Hauer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

(2016) Katerina Tsouroula et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Entropy gives rise to topologically associating domains

(2016) Paula A. Vasquez et al.   NUCLEIC ACIDS RESEARCH

Principles of chromatin organization in yeast: relevance of polymer models to describe nuclear organization and dynamics

(2015) Renjie Wang et al.   CURRENT OPINION IN CELL BIOLOGY

A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage

(2015) Marjolein van Sluis et al.   GENES & DEVELOPMENT

DNA loops generate intracentromere tension in mitosis

(2015) Josh Lawrimore et al.   JOURNAL OF CELL BIOLOGY

Interallelic complementation provides functional evidence for cohesin–cohesin interactions on DNA

(2015) Thomas Eng et al.   MOLECULAR BIOLOGY OF THE CELL

Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

(2015) Taehyun Ryu et al.   NATURE CELL BIOLOGY

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

(2015) Shane M. Harding et al.   Cell Reports

Three-dimensional topology of the SMC2/SMC4 subcomplex from chicken condensin I revealed by cross-linking and molecular modelling

(2015) H. Barysz et al.   Open Biology

Remodelers move chromatin in response to DNA damage

(2014) Andrew Seeber et al.   CELL CYCLE

Entangled Polymer Dynamics in Equilibrium and Flow Modeled Through Slip Links

(2014) Jay D. Schieber et al.   Annual Review of Chemical and Biomolecular Engineering

Polymer models of interphase chromosomes

(2014) Paula A Vasquez et al.   Nucleus

Submillisecond Elastic Recoil Reveals Molecular Origins of Fibrin Fiber Mechanics

(2013) Nathan E. Hudson et al.   BIOPHYSICAL JOURNAL

Chromatin Movement in the Maintenance of Genome Stability

(2013) Vincent Dion et al.   CELL

Cohesin and the nucleolus constrain the mobility of spontaneous repair foci

(2013) Vincent Dion et al.   EMBO REPORTS

High-throughput chromatin motion tracking in living yeast reveals the flexibility of the fiber throughout the genome

(2013) Houssam Hajjoul et al.   GENOME RESEARCH

Individual pericentromeres display coordinated motion and stretching in the yeast spindle

(2013) Andrew D. Stephens et al.   JOURNAL OF CELL BIOLOGY

Self-Healing of Unentangled Polymer Networks with Reversible Bonds

(2013) Evgeny B. Stukalin et al.   MACROMOLECULES

Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair

(2013) X. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

Effect of nuclear architecture on the efficiency of double-strand break repair

(2013) Neta Agmon et al.   NATURE CELL BIOLOGY

DNA in motion during double-strand break repair

(2013) Judith Miné-Hattab et al.   TRENDS IN CELL BIOLOGY

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

(2012) N. Wu et al.   GENES & DEVELOPMENT

Physical tethering and volume exclusion determine higher-order genome organization in budding yeast

(2012) H. Tjong et al.   GENOME RESEARCH

Increased chromosome mobility facilitates homology search during recombination

(2012) Judith Miné-Hattab et al.   NATURE CELL BIOLOGY

Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery

(2012) Vincent Dion et al.   NATURE CELL BIOLOGY

Nonthermal ATP-dependent fluctuations contribute to the in vivo motion of chromosomal loci

(2012) S. C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meiotic Chromosome Pairing Is Promoted by Telomere-Led Chromosome Movements Independent of Bouquet Formation

(2012) Chih-Ying Lee et al.   PLoS Genetics

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Reinforcement of Cohesin Binding at Pre-existing Cohesin Sites in Response to Ionizing Radiation in Human Cells

(2010) Beom-Jun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subdiffusive motion of a polymer composed of subdiffusive monomers

(2010) Stephanie C. Weber et al.   PHYSICAL REVIEW E

Bacterial Chromosomal Loci Move Subdiffusively through a Viscoelastic Cytoplasm

(2010) Stephanie C. Weber et al.   PHYSICAL REVIEW LETTERS

Cohesin Is Limiting for the Suppression of DNA Damage–Induced Recombination between Homologous Chromosomes

(2010) Shay Covo et al.   PLoS Genetics

Regulation of rDNA stability by sumoylation

(2009) Nadine Eckert-Boulet et al.   DNA REPAIR

Opposing Role of Condensin and Radiation-sensitive GeneRAD52in Ribosomal DNA Stability Regulation

(2009) Chi Kwan Tsang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishment of Cohesion at the Pericentromere by the Ctf19 Kinetochore Subcomplex and the Replication Fork-Associated Factor, Csm3

(2009) Josefin Fernius et al.   PLoS Genetics

Rapid Telomere Movement in Meiotic Prophase Is Promoted By NDJ1, MPS3, and CSM4 and Is Modulated by Recombination

(2008) Michael N. Conrad et al.   CELL