The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects

siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications

(2022) Yoshiaki Kobayashi et al.   ACS Omega

The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects

(2015) Piotr J. Kamola et al.   PLoS Computational Biology

Multiple sensors ensure guide strand selection in human RNAi pathways

(2013) C. L. Noland et al.   RNA

Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity

(2013) Kotaro Nakanishi et al.   Cell Reports

The Making of a Slicer: Activation of Human Argonaute-1

(2013) Christopher R. Faehnle et al.   Cell Reports

The Structure of Human Argonaute-2 in Complex with miR-20a

(2012) Elad Elkayam et al.   CELL

Structure of yeast Argonaute with guide RNA

(2012) Kotaro Nakanishi et al.   NATURE

The Crystal Structure of Human Argonaute2

(2012) N. T. Schirle et al.   SCIENCE

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

Dicer is dispensable for asymmetric RISC loading in mammals

(2011) J. G. Betancur et al.   RNA

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

ATP-dependent human RISC assembly pathways

(2009) Mayuko Yoda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural determinants of miRNAs for RISC loading and slicer-independent unwinding

(2009) Tomoko Kawamata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

(2009) A. Eulalio et al.   RNA

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

(2008) Kumiko Ui-Tei et al.   NUCLEIC ACIDS RESEARCH