Developmental Exposure to a Human-Relevant Polychlorinated Biphenyl Mixture Causes Behavioral Phenotypes That Vary by Sex and Genotype in Juvenile Mice Expressing Human Mutations That Modulate Neuronal Calcium

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

(2021) Jessica L. Haigh et al.   Genome Medicine

Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

(2021) J. Ellegood et al.   Molecular Autism

Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse

(2021) Kimberly P. Keil Stietz et al.   Frontiers in Neuroscience

Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity

(2020) Carolyn Klocke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lost in translation: At the crossroads of face validity and translational utility of behavioral assays in animal models for the development of therapeutics

(2020) J.L. Silverman et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology

(2020) Cristina Cheroni et al.   Molecular Autism

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

(2020) Harmanpreet Kaur Panesar et al.   Toxics

Identification of common genetic risk variants for autism spectrum disorder

(2019) Jakob Grove et al.   NATURE GENETICS

Comparative Analyses of the 12 Most Abundant PCB Congeners Detected in Human Maternal Serum for Activity at the Thyroid Hormone Receptor and Ryanodine Receptor

(2019) Sunjay Sethi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurotoxicity of polychlorinated biphenyls and related organohalogens

(2019) Isaac N. Pessah et al.   ACTA NEUROPATHOLOGICA

Developmental exposure to polychlorinated biphenyls (PCBs) in the maternal diet causes host-microbe defects in weanling offspring mice

(2019) Kavi M. Rude et al.   ENVIRONMENTAL POLLUTION

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

(2019) Carolyn Klocke et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder

(2018) Elizabeth L. Berg et al.   Autism Research

Emissions of Tetrachlorobiphenyls (PCBs 47, 51, and 68) from Polymer Resin on Kitchen Cabinets as a Non-Aroclor Source to Residential Air

(2018) Nicholas J. Herkert et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example

(2018) Xueshu Li et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

(2018) Xinzhu Yu et al.   NEURON

The contribution of environmental exposure to the etiology of autism spectrum disorder

(2018) Sven Bölte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Prospective Study of Environmental Exposures and Early Biomarkers in Autism Spectrum Disorder: Design, Protocols, and Preliminary Data from the MARBLES Study

(2018) Irva Hertz-Picciotto et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Genetic mutations in Ca2+ signaling alter dendrite morphology and social approach in juvenile mice

(2018) Kimberly P. Keil et al.   GENES BRAIN AND BEHAVIOR

Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons

(2018) Kimberly P Keil et al.   TOXICOLOGICAL SCIENCES

Polychlorinated biphenyls influence on autism spectrum disorder risk in the MARBLES cohort

(2018) Lauren Granillo et al.   ENVIRONMENTAL RESEARCH

MECHANISMS IN ENDOCRINOLOGY: Maternal thyroid dysfunction during pregnancy and behavioural and psychiatric disorders of children: a systematic review

(2017) Dagnachew Muluye Fetene et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome

(2017) Gaëlle Robin et al.   HUMAN MOLECULAR GENETICS

Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α

(2017) Z D Kabir et al.   MOLECULAR PSYCHIATRY

Detection of 3,3′-Dichlorobiphenyl in Human Maternal Plasma and Its Effects on Axonal and Dendritic Growth in Primary Rat Neurons

(2017) Sunjay Sethi et al.   TOXICOLOGICAL SCIENCES

Environmental factors in the development of autism spectrum disorders

(2016) L.A. Sealey et al.   ENVIRONMENT INTERNATIONAL

Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 1. Sexually dimorphic effects on social and anxiety-like behaviors

(2016) Margaret R. Bell et al.   HORMONES AND BEHAVIOR

Analysis of within Subjects Variability in Mouse Ultrasonic Vocalization: Pups Exhibit Inconsistent, State-Like Patterns of Call Production

(2016) Michael A. Rieger et al.   Frontiers in Behavioral Neuroscience

Developmental neurotoxicity of persistent organic pollutants: an update on childhood outcome

(2015) Sietske A. Berghuis et al.   ARCHIVES OF TOXICOLOGY

Metabolism and metabolites of polychlorinated biphenyls

(2015) Fabian A. Grimm et al.   CRITICAL REVIEWS IN TOXICOLOGY

Inhalation and Dietary Exposure to PCBs in Urban and Rural Cohorts via Congener-Specific Measurements

(2015) Matt D. Ampleman et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Human Serum from Urban and Rural Adolescents and Their Mothers Shows Exposure to Polychlorinated Biphenyls Not Found in Commercial Mixtures

(2015) Wen Xin Koh et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

(2015) Mu Yang et al.   PHYSIOLOGY & BEHAVIOR

Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice

(2015) Akito Nakao et al.   Frontiers in Behavioral Neuroscience

Polychlorinated biphenyls in the exterior caulk of San Francisco Bay Area buildings, California, USA

(2014) Susan Klosterhaus et al.   ENVIRONMENT INTERNATIONAL

Global Distribution and Local Impacts of Inadvertently Generated Polychlorinated Biphenyls in Pigments

(2014) Jia Guo et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome

(2014) Robert F Berman et al.   Journal of Neurodevelopmental Disorders

The Environmental Neurotoxicant PCB 95 Promotes Synaptogenesis via Ryanodine Receptor-Dependent miR132 Upregulation

(2014) Adam Lesiak et al.   JOURNAL OF NEUROSCIENCE

Economic Burden of Childhood Autism Spectrum Disorders

(2014) T. A. Lavelle et al.   PEDIATRICS

PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms

(2014) Dongren Yang et al.   TOXICOLOGICAL SCIENCES

Exome Sequencing Reveals Novel Rare Variants in the Ryanodine Receptor and Calcium Channel Genes in Malignant Hyperthermia Families

(2013) Jerry H. Kim et al.   ANESTHESIOLOGY

Association of gestational maternal hypothyroxinemia and increased autism risk

(2013) Gustavo C. Román et al.   ANNALS OF NEUROLOGY

Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis

(2013) N. Dlamini et al.   NEUROMUSCULAR DISORDERS

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography–tandem mass spectrometry in human serum and plasma

(2013) Yan-ping Lin et al.   TALANTA

Brain Hyperconnectivity in Children with Autism and its Links to Social Deficits

(2013) Kaustubh Supekar et al.   Cell Reports

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

(2012) Gary A. Wayman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

PCB-95 Promotes Dendritic Growth via Ryanodine Receptor–Dependent Mechanisms

(2012) Gary A. Wayman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities

(2012) Philip J Landrigan et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Signaling defects in iPSC-derived fragile X premutation neurons

(2012) Jing Liu et al.   HUMAN MOLECULAR GENETICS

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone

(2012) Zhengyu Cao et al.   HUMAN MOLECULAR GENETICS

Association between polychlorinated biphenyls and Parkinson's disease neuropathology

(2012) Jaime M. Hatcher-Martin et al.   NEUROTOXICOLOGY

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders

(2012) Marianna Stamou et al.   NEUROTOXICOLOGY AND TERATOLOGY

Autism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice

(2012) Jennifer Brielmaier et al.   PLoS One

FMR1 CGG allele size and prevalence ascertained through newborn screening in the United States

(2012) Flora Tassone et al.   Genome Medicine

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

(2011) Joachim Hallmayer   ARCHIVES OF GENERAL PSYCHIATRY

Behavioral profiles of mouse models for autism spectrum disorders

(2011) Elodie Ey et al.   Autism Research

Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage

(2011) Benjamin Yuen et al.   FASEB JOURNAL

Gene Dose Influences Cellular and Calcium Channel Dysregulation in Heterozygous and Homozygous T4826I-RYR1 Malignant Hyperthermia-susceptible Muscle

(2011) Genaro C. Barrientos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prevalence puzzle: Autism counts

(2011) Karen Weintraub   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

(2011) T. Adasme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse model of Timothy syndrome recapitulates triad of autistic traits

(2011) P. L. Bader et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

(2010) Dilja D. Krueger et al.   Annual Review of Medicine

Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders

(2010) Martha R Herbert   CURRENT OPINION IN NEUROLOGY

Polychlorinated Biphenyls (PCBs): Sources, Exposures, Toxicities

(2010) Keri Hornbuckle et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Behavioural phenotyping assays for mouse models of autism

(2010) Jill L. Silverman et al.   NATURE REVIEWS NEUROSCIENCE

Differential Effects of Polychlorinated Biphenyl Congeners on Serum Thyroid Hormone Levels in Rats

(2010) Lori Martin et al.   TOXICOLOGICAL SCIENCES

Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats

(2010) Banafsheh Jolous-Jamshidi et al.   TOXICOLOGY LETTERS

Human Genetic Disorders of Axon Guidance

(2010) E. C. Engle   Cold Spring Harbor Perspectives in Biology

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Autism and diagnostic substitution: evidence from a study of adults with a history of developmental language disorder

(2009) Dorothy V M Bishop et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Inadvertent Polychlorinated Biphenyls in Commercial Paint Pigments†

(2009) Dingfei Hu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration

(2009) Y. Chen et al.   HUMAN MOLECULAR GENETICS

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

(2009) Isaac N. Pessah et al.   PHARMACOLOGY & THERAPEUTICS

Comprehensive behavioral phenotyping of ryanodine receptor type3 (RyR3) knockout mice: Decreased social contact duration in two social interaction tests

(2009) Naoki Matsuo   Frontiers in Behavioral Neuroscience

Prenatal Exposure to Polychlorinated Biphenyls: A Neuropsychologic Analysis

(2008) Olivier Boucher et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

(2008) Dongren Yang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Rise in Autism and the Role of Age at Diagnosis

(2008) Irva Hertz-Picciotto et al.   EPIDEMIOLOGY

Neurodevelopmental and Neurophysiological Actions of Thyroid Hormone

(2008) G. R. Williams   JOURNAL OF NEUROENDOCRINOLOGY

Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disorders

(2008) Maria Luisa Scattoni et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS