Article
Cardiac & Cardiovascular Systems
Njabulo Ngwenyama, Annet Kirabo, Mark Aronovitz, Francisco Velazquez, Francisco Carrillo-Salinas, Ane M. Salvador, Tania Nevers, Venkataraman Amarnath, Albert Tai, Robert M. Blanton, David G. Harrison, Pilar Alcaide
Summary: The study found that TCR antigen recognition increases in the left ventricle as cardiac dysfunction progresses, with a limited repertoire of activated CD4+ T-cell clonotypes identified in the left ventricle. Antigen presentation of endogenous antigens was necessary for the development of cardiac dysfunction, and scavenging IsoLGs reduced TCR activation and prevented cardiac dysfunction. This highlights the important role of reactive oxygen species-induced formation of IsoLG-modified cardiac neoantigens in TCR-dependent CD4+ T-cell activation within the heart.
Article
Cardiac & Cardiovascular Systems
Christian Staehr, Palle Duun Rohde, Nikolaj Thure Krarup, Steffen Ringgaard, Christoffer Laustsen, Jacob Johnsen, Rikke Nielsen, Hans Christian Beck, Jens Preben Morth, Karin Lykke-Hartmann, Nichlas Riise Jespersen, Denis Abramochkin, Mette Nyegaard, Hans Erik Botker, Christian Aalkjaer, Vladimir Matchkov
Summary: The study suggests that mutations in the ATP1A2 gene may lead to disturbed cardiac metabolism and reduced cardiac function, potentially mediated through Na,K-ATPase-dependent reactive oxygen species signaling.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Environmental Sciences
Hongrui Guo, Zhicai Zuo, Fengyuan Wang, Caixia Gao, Kejie Chen, Jing Fang, Hengmin Cui, Ping Ouyang, Yi Geng, Zhengli Chen, Chao Huang, Yanqiu Zhu, Huidan Deng
Summary: The study investigated the relationship between obesity and heart health during non-fatal bacterial infection, finding that while infection led to cardiac inflammation, oxidative stress, and excessive apoptosis, obesity had a mitigating effect on these negative impacts.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Stephanie D. Burr, James A. Stewart
Summary: Heart failure is a common complication for individuals with type 2 diabetes mellitus, potentially caused by differentiation of fibroblasts to myofibroblasts associated with AGE/RAGE signaling.
Article
Fisheries
Baoshi Xu, Jilei Yin, Jingchao Qiang, Jiajie Gan, Xuhui Xu, Xing Li, Zunhan Hu, Zibo Dong
Summary: This study proposed the hypothesis that quercetin (QUE) may prevent carp poisoning by inhibiting avermectin (AVM) and investigated its protective effect against AVM-induced heart damage. The results showed that QUE reduced AVM toxicity symptoms, decreased enzyme levels, reduced cardiac fiber swelling, inhibited the accumulation of reactive oxygen species (ROS), increased antioxidant enzyme activity, and decreased apoptosis and autophagy. This study provides preliminary evidence for QUE attenuating AVM-induced myocardial injury in carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Zhiyong Lin, Fengwei Wang, Yawei Yan, Jiabao Jin, Zijiao Quan, Haibin Tong, Jie Du
Summary: Sp-Fuc can improve glucose and lipid metabolism disorders in diabetic mice by activating the Nrf2/ARE antioxidant signaling pathway, while reducing cardiac oxidative imbalance and inflammatory damage. This study provides a new perspective on the therapy strategy for T2DM and its complications.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Neda Hedayati, Alireza Yaghoobi, Marziyeh Salami, Yasaman Gholinezhad, Farnaz Aghadavood, Reza Eshraghi, Mohammad-Hossein Aarabi, Mina Homayoonfal, Zatollah Asemi, Hamed Mirzaei, Mohammad Hajijafari, Alireza Mafi, Malihe Rezaee
Summary: Polyphenols, which are abundant in regular diets, have various beneficial effects such as antioxidative, anti-inflammatory, anticancer, neuroprotective, and cardioprotective effects. Recent research has focused on the potential of polyphenols as alternative treatments for cardiac remodeling following cardiovascular diseases. Through a systematic search of online databases, it was found that polyphenols regulate vital molecules and signaling pathways associated with heart failure, such as fibrotic and hypertrophic factors, mitochondrial dysfunction, free radical production, apoptosis, and lipid profile and cellular metabolism. This study aims to provide a comprehensive review of the underlying mechanisms of different polyphenol subclasses in cardiac hypertrophy and heart failure, as well as investigate nano-drug delivery methods to optimize treatment outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Qitong Lu, Rui Zheng, Pengcheng Zhu, Jinhui Bian, Zhiyong Liu, Junjie Du
Summary: Hinokinin protects against HFD/STZ-induced cardiac injury in type 2 diabetes by alleviating oxidative stress, inflammation, and apoptosis, while also reducing hyperglycemia, dyslipidemia, and cardiac dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Yunjie Chen, Ning An, Xuan Zhou, Lin Mei, Yanru Sui, Gen Chen, Huinan Chen, Shengqu He, Cheng Jin, Zhicheng Hu, Wanqian Li, Yang Wang, Zhu Lin, Peng Chen, Litai Jin, Xueqiang Guan, Xu Wang
Summary: In this study, it was demonstrated that FGF20 protects against pathological cardiac hypertrophy by reducing oxidative stress through activation of the SIRT1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Kyle W. Eudailey, Betty Pat, Joo-Yeun Oh, Pamela C. Powell, James F. Collawn, James A. Mobley, Amit Gaggar, Clifton T. Lewis, James E. Davies, Rakesh Patel, Louis J. Dell'Italia
Summary: This study found that red blood cell and cardiac-derived exosomal hemoglobin may be involved in myocardial injury during cardiopulmonary bypass in patients with valvular heart disease.
ANNALS OF THORACIC SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Chunjie Jiang, Dan Li, Li Chen, Yang Liu, Ying Zhao, Guibin Mei, Yuhan Tang, Yuexin Yang, Ping Yao, Chao Gao
Summary: The study found that quercetin may improve cardiac function and myocardial fibrosis in diabetic cardiomyopathy by reducing inflammatory actions and regulating glycerophospholipid metabolism.
Article
Food Science & Technology
Yueh-Min Lin, Khan Farheen Badrealam, Wei-Wen Kuo, Pei Fang Lai, William Shao-Tsu Chen, Cecilia Hsuan Day, Tsung-Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih-Yang Huang
Summary: Nerolidol has been shown to ameliorate hypertension-induced cardiac injuries by targeting the TLR4/NF-kappa B signaling pathway, leading to reduced inflammation and oxidative stress, and providing effective cardioprotection. Echocardiography analysis demonstrated improved cardiac functional characteristics in hypertensive rats treated with nerolidol, highlighting its potential as a cardio-protective agent against hypertension-induced cardiac remodeling.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Yong Huang, Ziqin Wang, Yuyang Peng, Rong Xu, Jiajie Yan, Cong Xiong, Jinze Ma, Keyuan Zhong, Huiqiang Lu
Summary: Carboxin exhibits developmental and cardiotoxicity in zebrafish embryos, causing structural changes in the heart and disruption of heart developmental gene expression. Additionally, Carboxin induces oxidative stress and accumulation of reactive oxygen species (ROS) in zebrafish embryos, leading to mitochondrial damage and decreased ATPase activities. Carboxin also inhibits myocardial cell proliferation and decreases the number of blood cells in the heart, resulting in embryo death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Pharmacology & Pharmacy
Izabela Tuleta, Nikolaos G. Frangogiannis
Summary: Myocardial fibrosis in diabetic patients can lead to heart failure and arrhythmia due to factors such as hyperglycemia, lipotoxicity, and insulin resistance. While various biological processes have been implicated in diabetic fibrosis, specific therapeutic strategies targeting the fibrotic response remain limited.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Luna Jimenez-Castilla, Gema Marin-Royo, Macarena Orejudo, Lucas Opazo-Rios, Teresa Caro-Ordieres, Ines Artaiz, Tatiana Suarez-Cortes, Arturo Zazpe, Gonzalo Hernandez, Carmen Gomez-Guerrero, Jesus Egido
Summary: The synthetic flavonoid hidrosmin has shown protective effects against diabetic nephropathy by reducing inflammation, oxidative stress, and senescence pathways. It may have potential as an adjuvant therapy for chronic complications of diabetes mellitus. Additionally, hidrosmin demonstrated no cytotoxicity at effective concentrations, making it a promising treatment option.
Meeting Abstract
Endocrinology & Metabolism
Mohammed A. Alshawsh, Abdulsamad Alsalahi, Zahurin Mohamed, Nelli Giribabu, Zamri Chik
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biotechnology & Applied Microbiology
Naguib Salleh, Nurain Ismail, Giribabu Nelli, Kyaimon Myint, Si Lay Khaing
Summary: This study showed changes in the composition of cervical fluid at different phases of the female rat reproductive cycle, with high levels of Na+ and Cl- during estrus, high osmolarity during metestrus and diestrus, and varying expressions of ion channels such as CFTR, AQP-1, AQP-2, ENaC, AQP-5, and AQP-7 during different phases. These changes could impact female fertility.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Biology
Abdulsamad Alsalahi, Zamri Chik, Zahurin Mohamed, Nelli Giribabu, Mohammed Abdullah Alshawsh
Summary: The study found that cathinone had a weaker in vitro inhibition on alpha-amylase and alpha-glucosidase compared to alpha-acarbose, and it significantly affected the blood sugar levels of diabetic rats, exacerbating their hyperglycemia.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ker Woon Choy, Zuhaida Md Zain, Dharmani Devi Murugan, Nelli Giribabu, Nor Hisam Zamakshshari, Yang Mooi Lim, Mohd Rais Mustafa
Summary: The study found that HBN treatment significantly reversed the elevated fasting blood glucose, serum insulin, and levels of pro-inflammatory cytokines in db/db mice, improved OGTT, and did not affect the mice's body weight. Additionally, HBN treatment improved pathological changes and increased the protein expression of insulin and glucose transporters in the pancreas, liver, and skeletal muscle.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ajlaa Sofya Mohd Khalil, Nelli Giribabu, Suseela Yelumalai, Huma Shahzad, Eswar Kumar Kilari, Naguib Salleh
Summary: Myristic acid (MA) can protect testes against damage in diabetes mellitus (DM) by preventing oxidative stress, inflammation, and apoptosis, while maintaining steroidogenesis and spermatogenesis.
Article
Medicine, Research & Experimental
Nagarjuna Reddy Vendidandala, Tan Pei Yin, Giribabu Nelli, Visweswara Rao Pasupuleti, Shaik Nyamathulla, Seri Intan Mokhtar
Summary: This study investigated the wound healing ability of a combination of gallocatechin and silver nanoparticles in diabetic rats, showing significant improvements in wound healing and modulation of oxidative stress and inflammation.
Article
Multidisciplinary Sciences
Vendidandala Nagarjuna Reddy, Shaik Nyamathulla, Khomaizon Abdul Kadi Pahirulzaman, Seri Intan Mokhtar, Nelli Giribabu, Visweswara Rao Pasupulet
Summary: This study investigated the wound healing capabilities of gallocatechin (GC) and silver nanoparticles (AgNPs) impregnated patches in diabetic rats. The results showed that diabetic rats dressed with CGP2 and CGP3 along with silver sulfadiazine (AgS) patches had a higher wound healing rate. Furthermore, the dressing decreased changes in Wnt3a/beta-catenin pathways, resulting in lower apoptosis and greater proliferation, thus improving diabetic wound healing.
Review
Endocrinology & Metabolism
Nurulmuna Mohd Ghozali, Nelli Giribabu, Naguib Salleh
Summary: Vitamin D deficiency can lead to metabolic diseases such as obesity, hyperlipidemia, and diabetes mellitus. It impairs insulin secretion and beta-cell functions, exacerbates inflammation, oxidative stress, and apoptosis, resulting in insulin resistance and impaired glucose homeostasis.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Nur Ainina Abd Wahab, Nelli Giribabu, Eswar Kumar Kilari, Naguib Salleh
Summary: Abietic acid helps to mitigate nephropathy development in diabetes mellitus by counteracting oxidative stress, inflammation, and apoptosis.
Article
Biochemistry & Molecular Biology
Kamarulzaman Bin Karim, Nelli Giribabu, Naguib Bin Salleh
Summary: This study aims to identify the molecular mechanisms underlying the bone-protective effect of M. pumilum by involving RANK/RANKL/OPG and Wnt/β-catenin signaling pathways. The results showed that MPLA can alleviate osteoporosis and increase serum Ca2+ and PO43- levels.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Gowri Gopa Kumar, Eswar Kumar Kilari, Giribabu Nelli, Naguib Bin Salleh
Summary: This study aims to investigate the ability of Turnera diffusa leaf extract to improve testicular function in diabetic rats, and the results show that it can restore sperm parameters and testicular function in diabetic rats, suggesting its potential in restoring male fertility.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nurain Ismail, Kyaimon Myint, Si Lay Khaing, Nelli Giribabu, Naguib Salleh
Summary: This study identifies changes in the cervical fluid microenvironment and expression of ion transporters in the cervix that may contribute to unexplained infertility in women.
MOLECULAR BIOLOGY REPORTS
(2023)
