Article
Rheumatology
Lauren A. Henderson, Scott W. Canna, Kevin G. Friedman, Mark Gorelik, Sivia K. Lapidus, Hamid Bassiri, Edward M. Behrens, Anne Ferris, Kate F. Kernan, Grant S. Schulert, Philip Seo, Mary Beth F. Son, Adriana H. Tremoulet, Rae S. M. Yeung, Amy S. Mudano, Amy S. Turner, David R. Karp, Jay J. Mehta
Summary: This article provides guidance on the management of Multisystem Inflammatory Syndrome in Children (MIS-C) and hyperinflammation in children with coronavirus disease 2019 (COVID-19). A multidisciplinary Task Force developed 40 guidance statements and a flow diagram for the diagnostic pathway of MIS-C.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Dawn M. Wahezi, Mindy S. Lo, Tamar B. Rubinstein, Sarah Ringold, Stacy P. Ardoin, Kevin J. Downes, Karla B. Jones, Ronald M. Laxer, Rebecca Pellet Madan, Amy S. Mudano, Amy S. Turner, David R. Karp, Jay J. Mehta
Summary: The task force has approved 39 guidance statements, which were combined to form a total of 33 final guidance statements based on similar recommendations. All final statements received median vote ratings within the highest tertile of agreement and were associated with either moderate consensus (n = 5) or high consensus (n = 28).
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Emergency Medicine
Jaclyn N. Kline, Sarah C. Isbey, Nichole L. McCollum, Michael J. Falk, Camilo E. Gutierrez, Sabrina E. Guse, Ashraf S. Harahsheh, Kathleen M. Brown, James M. Chamberlain, Kristen A. Breslin
Summary: In this study, CRP elevation and lymphopenia were found to have high sensitivity and specificity for identifying children with Multisystem Inflammatory Syndrome in Children (MIS-C).
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Critical Care Medicine
Ye Liu, Yiming Li, Dongxue Xu, Jing Zhang, Zhiyong Peng
Summary: Severe COVID-19 patients exhibit paradoxical immune states, with the virus attacking the immune system leading to immunosuppression and heightened inflammation. Understanding the immune status in COVID-19 can aid in treatment strategies and therapy selection.
Article
Multidisciplinary Sciences
Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li, Jianguo Wu
Summary: This study reveals a unique mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation, leading to excessive inflammatory responses. The interaction between N protein and NLRP3 enhances the assembly of the NLRP3 inflammasome by facilitating binding with ASC.
NATURE COMMUNICATIONS
(2021)
Article
Rheumatology
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Summary: This study aims to provide guidance to rheumatology healthcare providers on the use of COVID-19 vaccines in patients with RMDs. Through a review of literature and expert opinions, consensus statements were developed to provide direction on the use of COVID-19 vaccines in RMD patients, despite limited direct evidence.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Summary: Despite limited clinical data, a task force of rheumatology providers developed 74 draft guidance statements for the use of COVID-19 vaccines in patients with rheumatic and musculoskeletal diseases, as well as recommendations on the use of immunomodulatory therapies around vaccination.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Summary: This study aims to provide guidance for rheumatology providers on the use of COVID-19 vaccines in patients with rheumatic and musculoskeletal diseases. By summarizing the available literature and data, the study offers recommendations on vaccine efficacy, safety, and the use of immunomodulatory therapies during vaccination.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Andrew Kroger, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Summary: A task force composed of rheumatologists, infectious disease specialists, and public health physicians developed 74 draft guidance statements regarding the use of COVID-19 vaccines in patients with rheumatic and musculoskeletal diseases, aiming to provide direction to rheumatology providers and facilitate vaccination strategies for RMD patients based on limited clinical data.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Jeffrey R. Curtis, Sindhu R. Johnson, Donald D. Anthony, Reuben J. Arasaratnam, Lindsey R. Baden, Anne R. Bass, Cassandra Calabrese, Ellen M. Gravallese, Rafael Harpaz, Rebecca E. Sadun, Amy S. Turner, Eleanor Anderson Williams, Ted R. Mikuls
Summary: This study aims to provide guidance to rheumatology providers on the use of COVID-19 vaccines in patients with rheumatic and musculoskeletal diseases. Despite limited direct evidence, consensus statements from the task force offer guidance and recommendations for vaccination strategies for RMD patients.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Physiology
Lukas Lacina, Jan Brabek, Sarka Fingerhutova, Jiri Zeman, Karel Smetana
Summary: COVID-19 is a transmissible respiratory disease caused by coronavirus SARS-CoV-2, with pediatric inflammatory multisystem syndrome (PIMS) being a new disease seen in children directly influenced by previous SARS-CoV-2 infection. PIMS can manifest complex clinical symptoms and may be fatal without intensive treatment, potentially linked to hyperactivation of immunity. Therapeutic manipulation of IL-6 or IL-6 receptor could be considered for severe cases.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Brittany P. Boribong, Thomas J. LaSalle, Yannic C. Bartsch, Felix Ellett, Maggie E. Loiselle, Jameson P. Davis, Anna L. K. Gonye, David B. Sykes, Soroush Hajizadeh, Johannes Kreuzer, Shiv Pillai, Wilhelm Haas, Andrea G. Edlow, Alessio Fasano, Galit Alter, Daniel Irimia, Moshe Sade-Feldman, Lael M. Yonker
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory disease characterized by SARS-CoV-2 antigenemia, cytokine storm, and immune dysregulation. Neutrophils in MIS-C display a distinct signature of granulocytic myeloid-derived suppressor cells (G-MDSC) and altered metabolism. Extensive neutrophil extracellular trap (NET) formation is observed in MIS-C.
CELL REPORTS MEDICINE
(2022)
Article
Immunology
Jingfei Li, Haotian Lin, Tinghui Fan, Linfei Huang, Xinyong Zhang, Yanhong Tai, Yi Fang, Qihong Li, Ruzhou Zhao, Penghao Wang, Li Zhou, Luming Wan, Yuhua Wu, Hui Zhong, Congwen Wei, Xiaopan Yang
Summary: In this study, it was found that the SARS-CoV-2 N protein promotes NLRP3 inflammasome activation by targeting BPOZ-2, which acts as a negative regulator of the inflammasome. It was also discovered that SARS-CoV-2 infection leads to decreased expression of BPOZ-2, and reintroduction of BPOZ-2 can effectively block the proinflammatory responses triggered by the SARS-CoV-2 N protein.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Letter
Medicine, General & Internal
Brian W. McCrindle, Ashraf S. Harahsheh, Ryan Handoko, Geetha Raghuveer, Michael A. Portman, Michael Khoury, Jane W. Newburger, Simon Lee, Supriya S. Jain, Manaswitha Khare, Nagib Dahdah, Cedric Manlhiot
Summary: The severity of multisystem inflammatory syndrome in children (MIS-C) has decreased with each subsequent SARS-CoV-2 variant, but critical illness remains prevalent in hospitalized patients with MIS-C.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Rheumatology
Ted R. Mikuls, Sindhu R. Johnson, Liana Fraenkel, Reuben J. Arasaratnam, Lindsey R. Baden, Bonnie L. Bermas, Winn Chatham, Stanley Cohen, Karen Costenbader, Ellen M. Gravallese, Andre C. Kalil, Michael E. Weinblatt, Kevin Winthrop, Amy S. Mudano, Amy Turner, Kenneth G. Saag
Summary: Guidance on managing adult rheumatic disease during the COVID-19 pandemic was developed by a task force of rheumatologists and infectious disease specialists. Through collating clinical questions, generating an evidence report, and using a modified Delphi process, final guidance statements were approved and presented as a living document due to the rapidly evolving literature and low level of available evidence. These statements aim to promote optimal care during the current pandemic with updates anticipated in the future.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Colleen K. Correll, Marcia M. Ditmyer, Jay Mehta, Lisa F. Imundo, Marisa S. Klein-Gitelman, Seetha U. Monrad, Daniel F. Battafarano
Summary: This study describes the current situation and future trends of the pediatric rheumatology workforce in the US. It reveals a significant gap between supply and demand, with the demand projected to be twice the supply by 2030. Innovative strategies are needed to improve access to care and increase the workforce supply.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Guangbo Chen, Gail H. Deutsch, Grant S. Schulert, Hong Zheng, SoRi Jang, Bruce Trapnell, Pui Y. Lee, Claudia Macaubas, Katherine Ho, Corinne Schneider, Vivian E. Saper, Adriana Almeida de Jesus, Mark A. Krasnow, Alexei Grom, Raphaela Goldbach-Mansky, Purvesh Khatri, Elizabeth D. Mellins, Scott W. Canna
Summary: This study investigated the immunopathology and identified biomarkers in systemic JIA, MAS, and SJIA-LD by measuring over 1,300 analytes in sera. The proteome alterations in active systemic JIA and MAS overlapped, with novel elevations in heat-shock proteins and glycolytic enzymes.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Mark Gorelik, Sharon A. Chung, Kaveh Ardalan, Bryce A. Binstadt, Kevin Friedman, Kristen Hayward, Lisa F. Imundo, Sivia K. Lapidus, Susan Kim, Mary Beth Son, Sangeeta Sule, Adriana H. Tremoulet, Heather Van Mater, Cagri Yildirim-Toruner, Carol A. Langford, Mehrdad Maz, Andy Abril, Gordon Guyatt, Amy M. Archer, Doyt L. Conn, Kathy A. Full, Peter C. Grayson, Maria F. Ibarra, Peter A. Merkel, Rennie L. Rhee, Philip Seo, John H. Stone, Robert P. Sundel, Omar Vitobaldi, Ann Warner, Kevin Byram, Anisha B. Dua, Nedaa Husainat, Karen E. James, Mohamad Kalot, Yih Chang Lin, Jason M. Springer, Marat Turgunbaev, Alexandra Villa-Forte, Amy S. Turner, Reem A. Mustafa
Summary: This study provides evidence-based recommendations and expert guidance for the management of Kawasaki disease, focusing on clinical scenarios more commonly addressed by rheumatologists. The recommendations include initial treatment with intravenous immunoglobulin, use of aspirin for incomplete Kawasaki disease, and obtaining an echocardiogram in certain situations.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Patricia Vega-Fernandez, Tracy Ting, Diane A. Mar, Andrew H. Schapiro, Mariani D. Deluna, Vivian E. Saper, Alexei A. Grom, Grant S. Schulert, Robert M. Fairchild
Summary: Lung ultrasound (US) shows highly conspicuous abnormalities in the pleura and subpleura in children with systemic juvenile idiopathic arthritis associated with lung disease (JIA-LD), which correlate with peripheral lung findings on high-resolution computed tomography (HRCT). Lung US is a feasible imaging tool in children and may have a potential role in JIA-LD screening, diagnosis, and/or prognostication.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Hermine Brunner, Ivan Foeldvari, Ekaterina Alexeeva, Nuray Aktay Ayaz, Inmaculada Calvo Penades, Ozgur Kasapcopur, Vyacheslav G. Chasnyk, Markus Hufnagel, Zbigniew Zuber, Grant Schulert, Seza Ozen, Adelina Rakhimyanova, Athimalaipet Ramanan, Christiaan Scott, Betul Sozeri, Elena Zholobova, Ruvie Martin, Xuan Zhu, Sarah Whelan, Luminita Pricop, Alberto Martini, Daniel Lovell, Nicolino Ruperto
Summary: This study demonstrates that secukinumab has a significant effect in prolonging the time to disease flare in children with ERA and JPsA, with a consistent safety profile to the adult indications.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Caroline Diorio, Rawan Shraim, Regina Myers, Edward M. Behrens, Scott Canna, Hamid Bassiri, Richard Aplenc, Chakkapong Burudpakdee, Fang Chen, Amanda M. DiNofia, Saar Gill, Vanessa Gonzalez, Michele P. Lambert, Allison Barz Leahy, Bruce L. Levine, Robert B. Lindell, Shannon L. Maude, J. Joseph Melenhorst, Haley Newman, Jessica Perazzelli, Alix E. Seif, Simon F. Lacey, Carl H. June, David M. Barrett, Stephan A. Grupp, David T. Teachey
Summary: In this study, we used proteomic profiling to identify predictive biomarkers for severe CRS and found that IFN gamma pathway plays a fundamental role in driving CRS. We also identified a potentially targetable cytokine associated with ICANS. These findings have important implications for disease treatment.
CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Rheumatology
Grant S. Schulert
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Kristine A. Kuhn, Andrew Stahly, Maximilian F. Konig, Kristine Carandang, Connie Herndon, Catherine Backman, Leigh F. Callahan, Grant Schulert, Liana Fraenkel, Alexis Ogdie
Summary: This study assessed the impact of the COVID-19 pandemic on trainees and early career investigators and proposed ways for the ACR and RRF to address their needs. The survey revealed that 75% of respondents pursuing academic research careers had to put their primary projects on hold during the pandemic. The suggested interventions included increased funding, funding process reform, and expanding mentoring and networking resources.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Pediatrics
Christopher Towe, Alexei A. Grom, Grant S. Schulert
Summary: Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is a potentially life-threatening complication. The optimal approaches to diagnosis and management of SJIA-LD are still unclear. This review discusses the current clinical understanding of SJIA-LD, including its potential pathogenesis and treatment options, and highlights the urgent unmet needs in this area.
Letter
Hematology
Matthew R. Schuelke, Hamid Bassiri, Edward M. Behrens, Scott Canna, Colleen Croy, Amanda DiNofia, Kandace Gollomp, Stephan Grupp, Michele Lambert, Arathi Lambrix, Shannon L. Maude, Regina Myers, Haley Newman, Whitney Petrosa, Alix Seif, Kathleen E. Sullivan, David T. Teachey, Caroline Diorio
Article
Rheumatology
Fabrizio De Benedetti, Alexei A. Grom, Paul A. Brogan, Claudia Bracaglia, Manuela Pardeo, Giulia Marucci, Despina Eleftheriou, Charalampia Papadopoulou, Grant S. Schulert, Pierre Quartier, Jordi Anton, Christian Laveille, Rikke Frederiksen, Veronica Asnaghi, Maria Ballabio, Philippe Jacqmin, Cristina de Min
Summary: The objective of this study was to confirm the adequacy of an emapalumab dosing regimen in relation to interferon-γ (IFN-γ) activity and assess its efficacy and safety in treating MAS secondary to sJIA or AOSD. The results showed that emapalumab was efficacious in inducing remission of MAS and viral infections were observed.
ANNALS OF THE RHEUMATIC DISEASES
(2023)